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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. De plus, nous expédions Sclerostin Anticorps (140) et Sclerostin Protéines (21) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 68 products:
Human Sclerostin Kit ELISA pour Sandwich ELISA - ABIN457071
Cidem, Usta, Karacan, Kucuk, Uludag, Gun: Effects of sex steroids on serum sclerostin levels during the menstrual cycle. dans Gynecologic and obstetric investigation 2013
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Human Sclerostin Kit ELISA pour Sandwich ELISA - ABIN415155
Brabnikova Maresova, Pavelka, Stepan: Acute effects of glucocorticoids on serum markers of osteoclasts, osteoblasts, and osteocytes. dans Calcified tissue international 2013
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Rat (Rattus) Sclerostin Kit ELISA pour Sandwich ELISA - ABIN416496
Kim, Lee, Jo, Song, Lim, Park, Bonewald, Kim: Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. dans Life sciences 2013
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Mouse (Murine) Sclerostin Kit ELISA pour Sandwich ELISA - ABIN426039
Yorgan, Peters, Jeschke, Benisch, Jakob, Amling, Schinke: The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
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Human Sclerostin Kit ELISA pour Sandwich ELISA - ABIN585199
Korkosz, Gąsowski, Leszczyński, Pawlak-Buś, Jeka, Siedlar, Grodzicki: Effect of tumour necrosis factor-α inhibitor on serum level of dickkopf-1 protein and bone morphogenetic protein-7 in ankylosing spondylitis patients with high disease activity. dans Scandinavian journal of rheumatology 2014
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Rat (Rattus) Sclerostin Kit ELISA pour Sandwich ELISA - ABIN585201
Ferreira, Ferrari, Neves, Cavallari, Dominguez, Dos Reis, Graciolli, Oliveira, Liu, Sabbagh, Jorgetti, Schiavi, Moysés: Effects of dietary phosphate on adynamic bone disease in rats with chronic kidney disease--role of sclerostin? dans PLoS ONE 2013
Serum sclerostin level was not an independent predictor of mortality in Maintenance Hemodialysis Patients
these results suggest a possible role of sclerostin in the identification of ankylosing spondylitis patients
important role for SOST SNP rs1877632 and VDR SNPs rs10735810 and rs731236 in the pathophysiology of stress fracture
In our cohort of pregnant women, sclerostin and DKK1 (Montrer DKK1 Kits ELISA) were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.
Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%
serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness
The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.
SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling pathway
No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.
Positivity of RANKL (Montrer TNFSF11 Kits ELISA) and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (Montrer TNFSF11 Kits ELISA) or SOST was associated with increased concentrations of the factors.
The SOST gene inhibited the expression of COL1, OCN, and OPN (Montrer SPP1 Kits ELISA), reduced the activity of alkaline phosphatase, and increased the expression of LPL (Montrer LPL Kits ELISA) and PPARgamma (Montrer PPARG Kits ELISA).
Since adipocytes do not produce sclerostin, these findings suggest an unexplored endocrine function for sclerostin that facilitates communication between the skeleton and adipose tissue.
A microtubule-dependent mechanotransduction pathway that linked fluid shear stress to reactive oxygen species and calcium (Ca2 (Montrer CA2 Kits ELISA)+) signals that led to a reduction in sclerostin abundance in cultured osteocytes.
osteoclast-derived LIF (Montrer LIF Kits ELISA) regulates bone turnover through sclerostin expression.
our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (Montrer FGF23 Kits ELISA) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages
These results show that osteocytes and/or osteoblasts secrete factors regulating beige (Montrer LYST Kits ELISA) adipogenesis, at least in part, through the Wnt (Montrer WNT2 Kits ELISA)-signaling inhibitor sclerostin.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (Montrer GJA1 Kits ELISA)+/-or Sost+/-mice
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (Montrer TNFSF11 Kits ELISA) and SOST, leading to osteoclast inhibition and Wnt (Montrer WNT2 Kits ELISA) activation together.
humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (Montrer PFDN5 Kits ELISA).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.