Sel-1 Suppressor of Lin-12-Like (C. Elegans) Protéines (SEL1L)

The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. De plus, nous expédions SEL1L Anticorps (90) et SEL1L Kits (1) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SEL1L 6400 Q9UBV2
SEL1L 20338 Q9Z2G6
Rat SEL1L SEL1L 314352 Q80Z70
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Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
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Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 60 to 65 Days
$7,506.65
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SEL1L Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human
,
Mouse (Murine)
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Plus protéines pour Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) partenaires d'interaction

Human Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L.

  2. Silencing of SEL1L during infection also stabilized an interaction of gO with the ER lectin OS-9, which likewise suggests that gO is an ER-associated degradation (ERAD) substrate. Taken together, our results identify an intriguing interaction of UL148 with the ERAD machinery and demonstrate that gO behaves as a constitutive ERAD substrate during infection.

  3. Together, these results suggest that ER stress might comprise an important factor in GCD2 pathophysiology and that the effects of 4-PBA treatment might have important implications for the development of GCD2 therapeutics.

  4. The SEL1L critically regulates HRD1-mediated disposal of misfolded cargo through its short membrane spanning stretch.

  5. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients

  6. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.

  7. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function.

  8. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.

  9. ATF6 represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.

  10. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP

  11. SEL1L expression is a potential colorectal cancer (CRC) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC cancers

  12. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.

  13. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells.

  14. regulation of the stability and assembly of the HRD1-SEL1L complex is critical to optimize the degradation kinetics of ERAD substrates

  15. Overexpression of SEL1L protein is likely an early event during the pathogenesis of esophageal squamous cell carcinoma.

  16. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro.

  17. Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population.

  18. Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture.

  19. Region within SEL1L between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth.

  20. SEL1L has a very complex structure consisting of 21 exons featuring several alternative transcripts encoding for putative protein isoforms. Its complexity ensures protein flexibility and specificity.

Mouse (Murine) Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) interaction partners

  1. he drastic phenotypic characteristics exhibited in mSEL-1L null mice can, in part, be explained by the negative influence it plays on Notch1 signaling pathway.

  2. This study implicates Endoplasmic reticulum (ER)-associated degradation mediated by Sel1L-Hrd1 as a key regulator of B cell development.

  3. Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus

  4. significant determinant of serum bile acid concentration

  5. The authors propose that certain Sel1-Like Repeat motifs of SEL1L play a unique role in membrane bound ERAD machinery.

  6. Sel1L-Hrd1 plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.

  7. Data show that inositol requiring enzyme 1alpha (IRE1alpha), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  8. Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL dimers from aggregation in the endoplasmic reticulum.

  9. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function.

  10. Sel1L is an indispensable component of the mammalian Hrd1 endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.

  11. a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth

  12. mSEL-1L as a primitive marker with a possible involvement in the regulation of neural progenitor stemness maintenance and lineage determination.

  13. an essential role for SEL1L in protein quality control during mouse embryonic development.

  14. Data suggest that Sel1l is essential for the growth and differentiation of endoderm-derived pancreatic epithelial cells during mouse embryonic development.

Profil protéine SEL1L

Profil protéine

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SEL1L

  • SEL1L ERAD E3 ligase adaptor subunit (SEL1L)
  • sel-1 suppressor of lin-12-like (C. elegans) (Sel1l)
  • SEL1L ERAD E3 ligase adaptor subunit (Sel1l)
  • sel-1 suppressor of lin-12-like L homeolog (sel1l.L)
  • sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)
  • sel-1 suppressor of lin-12-like (sel1l)
  • AW493766 Protéine
  • MGC99195 Protéine
  • mKIAA4137 Protéine
  • PRO1063 Protéine
  • Sel-1L Protéine
  • SEL1-LIKE Protéine
  • Sel1h Protéine
  • SEL1L Protéine
  • SEL1L1 Protéine

Protein level used designations for SEL1L

Suppressor of lin 12 (sel-1), C. elegans, homolog of , protein sel-1 homolog 1 , sel-1 suppressor of lin-12-like 1 , suppressor of lin-12-like protein 1 , Sel1 (suppressor of lin-12) 1 homolog , sel-1L , sel-1 suppressor of lin-12-like (C. elegans) , sel-1 suppressor of lin-12-like , protein sel-1 homolog 1-like , Suppressor of lin-12-like protein 1

GENE ID SPECIES
6400 Homo sapiens
20338 Mus musculus
314352 Rattus norvegicus
423391 Gallus gallus
453080 Pan troglodytes
480409 Canis lupus familiaris
614959 Bos taurus
708651 Macaca mulatta
735099 Xenopus laevis
100052711 Equus caballus
100155424 Sus scrofa
100231514 Taeniopygia guttata
100353303 Oryctolagus cuniculus
100377925 Saccoglossus kowalevskii
100380038 Xenopus (Silurana) tropicalis
100408799 Callithrix jacchus
100477463 Ailuropoda melanoleuca
100548852 Meleagris gallopavo
100583688 Nomascus leucogenys
101834260 Mesocricetus auratus
100730201 Cavia porcellus
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