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The protein encoded by SEL1L is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. De plus, nous expédions SEL1L Anticorps (88) et SEL1L Kits (1) et beaucoup plus de produits pour cette protéine.
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Silencing of SEL1L during infection also stabilized an interaction of gO with the ER lectin (Montrer ERLEC1 Protéines) OS-9 (Montrer OS9 Protéines), which likewise suggests that gO is an ER-associated degradation (ERAD) substrate. Taken together, our results identify an intriguing interaction of UL148 with the ERAD machinery and demonstrate that gO behaves as a constitutive ERAD substrate during infection.
The SEL1L critically regulates HRD1 (Montrer SYVN1 Protéines)-mediated disposal of misfolded cargo through its short membrane spanning stretch.
this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients
Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma.
Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin (Montrer INS Protéines) signalling to create a favourable micro-environment for ss-cell development and function.
SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties.
ATF6 (Montrer ATF6 Protéines) represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.
ERdj5 (Montrer DNAJC10 Protéines), by binding to Sel1L, triggers BiP (Montrer GDF10 Protéines)-Cholera toxin interaction proximal to the Hrd1 (Montrer SYVN1 Protéines) complex; postulate this scenario enables the Hrd1 (Montrer SYVN1 Protéines)-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP (Montrer GDF10 Protéines)
SEL1L expression is a potential colorectal cancer (CRC (Montrer CALR Protéines)) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC (Montrer CALR Protéines) cancers
the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers.
This study implicates Endoplasmic reticulum (ER)-associated degradation mediated by Sel1L-Hrd1 (Montrer SYVN1 Protéines) as a key regulator of B cell development.
Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus
The authors propose that certain Sel1-Like Repeat motifs of SEL1L play a unique role in membrane bound ERAD machinery.
Sel1L-Hrd1 (Montrer SYVN1 Protéines) plays a constitutive role in endoplasmic reticulum associated degradation in epithelial cell biology and the pathogenesis of intestinal inflammation in Crohn's disease.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (Montrer ERN1 Protéines)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L proten-Hrd1 protein (Montrer SYVN1 Protéines) endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Adipocyte-specific Sel1L-deficient (AKO) mice are resistant to diet-induced obesity. Sel1L stabilizes and prevents LPL (Montrer LPL Protéines) dimers from aggregation in the endoplasmic reticulum.
Sel1L is an indispensable component of the mammalian Hrd1 (Montrer SYVN1 Protéines) endoplasmic reticulum-associated degradation and endoplasmic reticulum homeostasis.
a critical and previously unknown function for SEL1L in regulating adult beta-cell function and growth
an essential role for SEL1L in protein quality control during mouse embryonic development.
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Suppressor of lin 12 (sel-1), C. elegans, homolog of
, protein sel-1 homolog 1
, sel-1 suppressor of lin-12-like 1
, suppressor of lin-12-like protein 1
, Sel1 (suppressor of lin-12) 1 homolog
, sel-1 suppressor of lin-12-like (C. elegans)
, sel-1 suppressor of lin-12-like
, protein sel-1 homolog 1-like
, Suppressor of lin-12-like protein 1