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SEPHS2 encodes an enzyme that synthesizes selenophosphate from selenide and ATP. De plus, nous expédions SEPHS2 Protéines (6) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal SEPHS2 Primary Antibody pour IHC (p), ELISA - ABIN543003
Guimarães, Peterson, Vicari, Cocks, Copeland, Gilbert, Jenkins, Ferrick, Kastelein, Bazan, Zlotnik: Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism? dans Proceedings of the National Academy of Sciences of the United States of America 1997
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Polyclonal SEPHS2 Primary Antibody pour IP, ELISA - ABIN539550
Low, Harney, Berry: Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis. dans The Journal of biological chemistry 1995
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the transcriptome of fruit flies with knockdown of SPS2 in larval and adult stages, is reported.[Sps2]
The downstream DNA replication-related element has been identified as an essential element for dsps2 promoter activity.
Thus, bovine active selenophosphate synthetase 2 of molecular mass 33 kDa does not contain selenocysteine.
These in vivo studies indicate that SPS2 is essential for generating the selenium donor for selenocysteine biosynthesis in mammals.
Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS, SECP43, SEPHS1, and SEPHS2); SECP43, which interacts with SEPSECS and SEPHS1, is a globular protein that forms oligomers in vivo.
miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression.In the case of SEPHS2 this may contribute to maintaining selenoprotein synthesis.
the Sps1-encoded enzyme depends on a selenium salvage system that recycles l-selenocysteine, whereas the Sps2 enzyme can function with a selenite assimilation system
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. This protein itself contains a selenocysteine residue in its predicted active site. The 3' UTR of the gene has a stem-loop secondary structure called a selenocysteine insertion sequence (SECIS) element, which allows UGA to direct the incorporation of selenocysteine rather than signal a translational stop. Alternatively spliced transcripts have been identified, but their biological validity has not been determined.
, selenophosphate synthetase 2
, selenide, water dikinase 2
, clone 1000
, selenium donor protein 2
, selenophosphate synthase 2
, the SelD gene product