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SETX encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein.
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Human Polyclonal SETX Primary Antibody pour IP, WB - ABIN252880
Richard, Feng, Manley: A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. dans Genes & development 2013
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Human Polyclonal SETX Primary Antibody pour ICC, IF - ABIN4352660
Choudhury, Vs, Mushtaq, Kumar: Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation. dans Synapse (New York, N.Y.) 2017
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Human Polyclonal SETX Primary Antibody pour ChIP, IP - ABIN252881
Zhao, Gish, Braunschweig, Li, Ni, Schmitges, Zhong, Liu, Li, Moffat, Vedadi, Min, Pawson, Blencowe, Greenblatt: SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. dans Nature 2016
Data suggest that senataxin (SETX) functions at DNA double-strand breaks (DSBs) in order to limit translocations and ensure cell viability.
Expression of AOA2-causative form of SETX in Drosophila muscles resulted in an alteration of translational repression of Elav.
The pan (Montrer SUPT6H Anticorps)-neuronal expression of wild-type or mutant forms of human senataxin induced morphological plasticity at neuromuscular junction synapses.
Novel compound heterozygous mutations of SETX in Chinese AOA2 pedigree were identified, which broaden the mutation spectrum of SETX.
The role of senataxin in regulating gene expression on a genome-wide scale in Ataxia oculomotor apraxia 2 neurons is described.
these data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.
AOA2 with myoclonus associated with mutations in SETX and AFG3L2 (Montrer AFG3L2 Anticorps)
BRCA1/SETX complexes support a DNA repair mechanism that addresses R-loop-based DNA damage at transcriptional pause sites.
Results identify novel genes related to senataxin function in normal and disease states.
genetic variations in the senataxin gene may contribute to Alzheimer's disease pathogenesis in the Taiwanese Han population.
These data support key roles for senataxin in coordinating meiotic crossing-over with transcription and in gene silencing to protect the integrity of the genome.
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).
, amyotrophic lateral sclerosis 4
, probable helicase senataxin-like
, SEN1 homolog
, amyotrophic lateral sclerosis 4 protein
, probable helicase senataxin
, amyotrophic lateral sclerosis 4 homolog
, amyotrophic lateral sclerosis 4 protein homolog
, DEAxQ-box helicase
, tRNA splicing endonuclease regulator 1