Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Kits ELISA

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. De plus, nous expédions Sialic Acid Binding Ig-Like Lectin 7 Anticorps (184) et Sialic Acid Binding Ig-Like Lectin 7 Protéines (12) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SIGLEC7 27036 Q9Y286
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.065 ng/mL 0.156 ng/mL - 10 ng/mL Typical standard curve SDS-PAGE of Protein Standard from the Kit (Highly purified E. coli-expressed recombinant human SIGLEC7). 96 Tests 12 to 14 Days
  96 Tests 11 to 16 Days

Plus Kits ELISA pour Sialic Acid Binding Ig-Like Lectin 7 partenaires d'interaction

Human Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) interaction partners

  1. Data reported that Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Furthermore, Siglec-7 seems to play a critical role in the maintenance of an immune-suppressive anti-inflammatory microenvironment, which is lost in diabetes, and may contribute to the manifestation and progression of this metabolic syndrome.

  2. NK cells with Siglec-7neg phenotype possess a high and sustainable killing activity and have the capability to eliminate a NK-resistant leukemia cell and hypersialylated tumor cells

  3. CD56bright NK cells from obese subjects had a reduced expression of Siglec-7

  4. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities.

  5. Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils.

  6. These results show that Siglec-7 binds HIV-1 via gp120 and contributes to enhance the susceptibility to infection of CD4 positive T cells and monocyte-derived macrophages.

  7. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.

  8. Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis.

  9. Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition.

  10. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors.

  11. high resolution crystal structures of this protein; insights into ligand specificity of this family of proteins

  12. Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells.

  13. x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1

  14. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity

  15. Siglec-7 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2.

  16. upon pervanadate (PV) treatment, Siglec-7 recruited the protein tyrosine phosphatases Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase-1 and SHP-2 less efficiently than did other inhibitory receptors

  17. structural analysis of siglec-7 in complex with sialosides

  18. Siglecs-7 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid.

  19. The expression levels of Siglec-7 were detectable in bone marrow plasma from AML patients and serum from normal donors.

  20. The species-specific differences in the expression expression of Siglecs in SIV infection was studied.

Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) profil antigène

Antigen Summary

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene names and symbols associated with SIGLEC7

  • sialic acid-binding Ig-like lectin 7 (LOC468976) anticorps
  • sialic acid binding Ig like lectin 7 (SIGLEC7) anticorps
  • AIRM1 anticorps
  • CD328 anticorps
  • CDw328 anticorps
  • D-siglec anticorps
  • p75 anticorps
  • p75/AIRM1 anticorps
  • QA79 anticorps
  • SIGLEC-7 anticorps
  • SIGLEC7 anticorps
  • SIGLEC19P anticorps
  • SIGLECP2 anticorps

Protein level used designations for SIGLEC7

sialic acid binding Ig-like lectin 7 , AIRM-1 , QA79 membrane protein , adhesion inhibitory receptor molecule 1, siglec-7 , sialic acid binding immunoglobulin-like lectin 7 , sialic acid-binding Ig-like lectin 7

468976 Pan troglodytes
100591540 Nomascus leucogenys
27036 Homo sapiens
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