Plus produit pour SIGLEC8 ELISA Kit
SIGLEC8 Kits ELISA mieux référencés
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Human SIGLEC8 Kit ELISA pour Sandwich ELISA - ABIN1117102 : Arakawa, Suzukawa, Ohshima, Tashimo, Asari, Matsui, Kobayashi, Shoji, Nagase, Ohta: Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab. dans Allergology international : official journal of the Japanese Society of Allergology 2019 (PubMed)
Plus Kits ELISA pour SIGLEC8 partenaires d'interaction
Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) interaction partners
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These data demonstrate that Siglec-8 functions uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset of protein kinases
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Targeting saporin to Siglec-8 consistently caused extensive cell death.
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In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2.
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miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.
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Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer
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Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.
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Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.
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Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping
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In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.
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Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis.
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Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia.
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Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.
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expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells
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The Siglec-8 gene may be a susceptibility locus for asthma.
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Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis
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Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl
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Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage.
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IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence.
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First reported inhibitory effects of Siglec engagement on human mast cells.
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A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils.
SIGLEC8 profil antigène
Antigen Summary
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000
Gene names and symbols associated with SIGLEC8
- sialic acid binding Ig like lectin 8 (SIGLEC8) anticorps
- sialic acid-binding Ig-like lectin 8 (LOC506364) anticorps
- SAF2 anticorps
- SIGLEC-8 anticorps
- SIGLEC8 anticorps
- SIGLEC8L anticorps
Protein level used designations for SIGLEC8
CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8
GENE ID | SPECIES |
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27181 | Homo sapiens |
456249 | Pan troglodytes |
506364 | Bos taurus |
100595640 | Nomascus leucogenys |
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