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Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. De plus, nous expédions SIGLEC8 Anticorps (76) et SIGLEC8 Protéines (7) et beaucoup plus de produits pour cette protéine.
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In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 (Montrer OLIG2 Kits ELISA) by an OLIG2 (Montrer OLIG2 Kits ELISA) small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2 (Montrer OLIG2 Kits ELISA).
miR (Montrer MLXIP Kits ELISA)-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.
Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer
Ligands for Siglec-8 and Siglec-9 (Montrer SIGLEC9 Kits ELISA) may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.
Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 (Montrer SIGLEC9 Kits ELISA) sialoglycan ligands on human airways.
Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (Montrer ARCN1 Kits ELISA) pathogenesis and may influence COPD (Montrer ARCN1 Kits ELISA) phenotyping
In activated eosinophils ligation of Siglec-8 leads to ROS (Montrer ROS1 Kits ELISA)-dependent enhancement of IL-5 (Montrer IL5 Kits ELISA)-induced ERK (Montrer EPHB2 Kits ELISA) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.
Engagement of Siglec-8 on blood eosinophils results in caspase (Montrer CASP3 Kits ELISA)- and mitochondria-dependent apoptosis.
Eosinophils primed by IL-33 (Montrer IL33 Kits ELISA) and/or IL-5 (Montrer IL5 Kits ELISA) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.
The Siglec-8 gene may be a susceptibility locus for asthma.
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000
, sialic acid-binding Ig-like lectin 8
, sialoadhesin family member 2
, sialic acid binding Ig-like lectin 8