anti-Signal Peptide Peptidase-Like 2B (SPPL2B) Anticorps

SPPL2B encodes a member of the GXGD family of aspartic proteases. De plus, nous expédions SPPL2B Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SPPL2B 56928 Q8TCT7
SPPL2B 73218 Q3TD49
SPPL2B 362828 Q5PQL3
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Top anti-SPPL2B Anticorps sur anticorps-enligne.fr

Showing 6 out of 6 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit Target Name: SPPL2B Sample Type: 293T Whole cell lysates Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
$581.17
Détails
Humain Lapin Inconjugué IHC, WB SPPL2B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X SPPL2B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg 9 to 11 Days
$449.29
Détails
Humain Lapin Inconjugué IHC, ELISA, WB 100 μL 2 to 3 Days
$446.88
Détails
Humain Lapin Inconjugué WB   100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB   100 μL 3 to 7 Days
$317.90
Détails

Plus d’anticorps contre SPPL2B partenaires d’interaction

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha into the cytosol.

  6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) interaction partners

  1. in vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 proteolysis in B and dendritic cells

SPPL2B profil antigène

Profil protéine

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPPL2B

  • signal peptide peptidase-like 2 (sppl2) anticorps
  • signal peptide peptidase like 2B (sppl2b) anticorps
  • signal peptide peptidase like 2B S homeolog (sppl2b.S) anticorps
  • signal peptide peptidase like 2B (SPPL2B) anticorps
  • signal peptide peptidase like 2B (Sppl2b) anticorps
  • signal peptide peptidase-like 2B (Sppl2b) anticorps
  • 3110056O03Rik anticorps
  • AW550292 anticorps
  • IMP-4 anticorps
  • IMP4 anticorps
  • MGC147524 anticorps
  • PSH4 anticorps
  • PSL1 anticorps
  • RGD1308556 anticorps
  • SPPL2B anticorps
  • wu:fc16e01 anticorps
  • wu:fc85d12 anticorps
  • zgc:136525 anticorps

Protein level used designations for SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPECIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
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