Signal-Regulatory Protein alpha (SIRPA) Kits ELISA

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. De plus, nous expédions SIRPA Anticorps (172) et SIRPA Protéines (36) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
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Top SIRPA Kits ELISA sur anticorps-enligne.fr

Showing 7 out of 13 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Détails
Souris 7.8 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Détails
Humain
  96 Tests 2 to 3 Days
$380.00
Détails
Humain < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   100 Tests 2 to 3 Days
$695.00
Détails
Rat < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests 11 to 18 Days
$838.60
Détails
Humain < 0.056 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$902.56
Détails
Boeuf (Vache)
  96 Tests 15 to 18 Days
$1,029.60
Détails

Plus Kits ELISA pour SIRPA partenaires d'interaction

Human Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. Collectively, the rs2477686 in PEX10 , rs6080550 in SIRPA-SIRPG, and rs10842262 in SOX5 gene may indeed be the genetic risk factors for nonobstructive azoospermia (NOA), which requires further investigation using larger independent sets of samples in different ethnic populations.

  2. QPCTL is critical for pyroglutamate formation on CD47 at the SIRPalpha binding site shortly after biosynthesis.

  3. Accumulation of SIRPalpha-inhibited macrophages in tumors favored tumor regression for 1-2 weeks, but donor macrophages quickly differentiated toward non-phagocytic, high-SIRPalpha TAMs.

  4. SIRP alpha protein is under-expressed in low and high-grades of astrocytoma from patients' brain samples.

  5. Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

  6. SIRPalpha might play an important role in the progression of oral leukoplakia and oral cancer, and could be a pivotal therapeutic target in oral squamous cell carcinoma, regulating the phenotype of macrophages via targeting NF-kappaB signaling.

  7. TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47-SIRPalpha axis by binding to human CD47 and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.

  8. data suggest that TTI-621 may be efficacious in triggering the destruction of cancer cells by a diverse population of TAMs found in vivo and support possible combination approaches to augment the activity of CD47 blockade

  9. CD47, TSP1, and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  10. exploited by Hepatitis E virus to negative regulated IFN-beta of the host innate immune system to promote viral infection

  11. Data suggest a reduction in the CD47 antigen/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  12. agents that block the CD47:SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  13. the data suggest that combinatorial actions of ADAM10 and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

  14. Loss of cell surface CD47 clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

  15. Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis

  16. negatively regulates neutrophil accumulation during inflammation

  17. Combinatorial expression of NKX2-5, SIRPA, VCAM1 and CD34 can be used to define discrete stages of cardiovascular cell lineage differentiation.

  18. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG.

  19. These results suggest that thrombospondin-1 binding to SIRP-alpha on nonphagocytic cells activates NADPH oxidase, limits vasodilation, and promotes renal ischemia reperfusion injury.

  20. 'clustering' SIRPalpha into plasma membrane microdomains is essential for activated monocytes and macrophages to effectively interact with CD47 and initiate intracellular signaling

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. these results demonstrate that CD47-SIRPalpha signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs

  2. this study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis

  3. Data indicate that only signal regulatory protein alpha (SIRPalpha+) CD8(+) T cells actively proliferate and show cytolytic activity.

  4. Microglia are effector cells of CD47-SIRPalpha antiphagocytic axis disruption against glioblastoma.

  5. Tyrosine phosphorylation of SIRPalpha is necessary for SIRPalpha cleavage and presynaptic maturation.

  6. Accumulation of SIRPalpha-inhibited macrophages in tumors favored tumor regression for 1-2 weeks, but donor macrophages quickly differentiated toward non-phagocytic, high-SIRPalpha TAMs.

  7. Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

  8. SIRPalpha-expressing dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult mouse spleen.

  9. CCR7 deficiency results in apoptosis of Sirpa- dendritic cells, which is counterbalanced by expansion of immature Sirpa+ dendritic cells that efficiently induce Treg generation.

  10. Mechanistic studies suggest a PKC-Syk-mediated signaling pathway, to which IL-10 conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47(-/-) or Sirpalpha(-/-) mice.

  11. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  12. Data provide evidence that SIRPalpha-mediated phagocytosis is not a major determinant in prion disease pathogenesis.

  13. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47-SIRPA interaction and Rac1/Akt activation.

  14. In conclusion, our data suggest that SIRPalpha signaling through SHP-2-PI3K-Akt2 strongly influences osteoblast differentiation from bone marrow stromal cells.

  15. These results indicate an important role for CD47-SIRPalpha interactions in innate control of malaria and suggest novel targets for intervention.

  16. TLR5 mediates CD172a(+) intestinal lamina propria dendritic cell induction of Th17 cells.

  17. a novel and opposite contribution of SIRPalpha signaling within non-hematopoietic and hematopoietic cells

  18. These findings demonstrate, for the first time, that SIRPalpha signaling can directly control phagocyte migration.

  19. SIRPalpha intrinsic to CD11c(+) dendritic cells is essential for homeostasis of conventional dendritic cells in the secondary lymphoid organs and skin.

  20. Loss of cell surface CD47 clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.

SIRPA profil antigène

Antigen Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene names and symbols associated with SIRPA

  • signal regulatory protein alpha (SIRPA) anticorps
  • signal-regulatory protein alpha (SIRPA) anticorps
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC458039) anticorps
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100400378) anticorps
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100590224) anticorps
  • signal-regulatory protein alpha (Sirpa) anticorps
  • AI835480 anticorps
  • Bit anticorps
  • CD172a anticorps
  • MFR anticorps
  • MYD-1 anticorps
  • P84 anticorps
  • Ptpns1 anticorps
  • SHP-1 anticorps
  • SHPS-1 anticorps
  • SHPS1 anticorps
  • SIRP anticorps
  • SIRP-A1 anticorps
  • SIRP-B1 anticorps
  • SIRPA anticorps
  • swc3 anticorps

Protein level used designations for SIRPA

CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , MyD-1 antigen , SHP substrate 1 , SHPS-1 , protein tyrosine phosphatase, non-receptor type substrate 1 , signal-regulatory protein alpha-1 , sirp-alpha-1 , signal-regulatory protein alpha , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen

GENE ID SPECIES
140885 Homo sapiens
327666 Bos taurus
419267 Gallus gallus
458039 Pan troglodytes
609452 Canis lupus familiaris
717811 Macaca mulatta
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
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