Sirtuin 5 (SIRT5) Kits ELISA

SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. De plus, nous expédions Sirtuin 5 Anticorps (192) et Sirtuin 5 Protéines (20) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SIRT5 23408 Q9NXA8
SIRT5 68346 Q8K2C6
SIRT5 306840 Q68FX9
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Top Sirtuin 5 Kits ELISA sur anticorps-enligne.fr

Showing 6 out of 20 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.067 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$736.84
Détails
Rat < 0.081 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$653.82
Détails
Souris
  96 Tests Connectez-vous pour afficher 11 to 18 Days
$653.82
Détails
Boeuf (Vache)
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$1,029.60
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Poulet
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$1,095.60
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Chien
  96 Tests Connectez-vous pour afficher 15 to 18 Days
$1,095.60
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Plus Kits ELISA pour Sirtuin 5 partenaires d'interaction

Human Sirtuin 5 (SIRT5) interaction partners

  1. High SIRT5 expression is associated with Cancer Cell Proliferation.

  2. The DNA variants and SNPs identified in acute Myocardial infection (AMI (Montrer CFD Kits ELISA)) patients may change SIRT5 level by affecting activity of SIRT5 gene promoter, contributing to the AMI (Montrer CFD Kits ELISA) development as a risk factor.

  3. In this study, we summarize biological functions of SIRT5 reported in normal tissues and in cancer and discuss potential mechanisms whereby SIRT5 may impact tumorigenesis, particularly focusing on its reported roles in metabolic reprogramming. Finally, we review current efforts to target SIRT5 pharmacologically

  4. The roles of the CDK2 (Montrer CDK2 Kits ELISA)/SIRT5 axis in gastric cancer.

  5. SIRT5 gene has an important regulatory role in liver carcinogenesis, and may function as a novel potential therapeutic target for HCC.

  6. This study showed that SIRT5 supports the anaplerotic entry of glutamine (Montrer GFPT1 Kits ELISA) into the TCA cycle in malignant phenotypes of CRC (Montrer CALR Kits ELISA) via activating GLUD1 (Montrer GLUD1 Kits ELISA).

  7. Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.

  8. The function of the three mitochondrial sirtuins (SIRT3 (Montrer SIRT3 Kits ELISA), SIRT4 (Montrer SIRT4 Kits ELISA), SIRT5) and their role in disease are reviewed.

  9. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.

  10. Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.

Mouse (Murine) Sirtuin 5 (SIRT5) interaction partners

  1. Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon (Montrer PRKCE Kits ELISA)) activation in the brain.

  2. findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival

  3. Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (Montrer CRMP1 Kits ELISA) and to mitochondrial fragmentation.

  4. Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.

  5. Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.

  6. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha (Montrer PPARGC1A Kits ELISA)) overexpression significantly increased the expression of sirtuin 3 (SIRT3 (Montrer SIRT3 Kits ELISA)) and sirtuin 5 (SIRT5).

  7. In the cochlea, the expression of SIRT1 (Montrer SIRT1 Kits ELISA), 3, and 5 (both mRNA and protein) was decreased in the old mice

  8. These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.

  9. Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (Montrer SDHA Kits ELISA)), implicating alteration in SDH (Montrer SDS Kits ELISA) activity as causative of the injury.

  10. SIRT5 has a role in cellular metabolism with a multiple enzymatic activities

Cow (Bovine) Sirtuin 5 (SIRT5) interaction partners

  1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.

Sirtuin 5 (SIRT5) profil antigène

Antigen Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with Sirtuin 5 (SIRT5) Kits ELISA

  • sirtuin 5 (SIRT5) anticorps
  • sirtuin 5 (Sirt5) anticorps
  • sirtuin 5 (sirt5) anticorps
  • sirtuin 5 L homeolog (sirt5.L) anticorps
  • sirtuin 5 (CC1G_00083) anticorps
  • 0610012J09Rik anticorps
  • 1500032M05Rik anticorps
  • AV001953 anticorps
  • sir2l5 anticorps
  • SIRT5 anticorps
  • sirt5-a anticorps
  • zgc:92288 anticorps

Protein level used designations for Sirtuin 5 (SIRT5) Kits ELISA

NAD-dependent deacetylase sirtuin-5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial , NAD-dependent protein deacylase sirtuin-5, mitochondrial , SIR2-like protein 5 , regulatory protein SIR2 homolog 5 , silent mating type information regulation 2, S.cerevisiae, homolog 5 , sir2-like 5 , sirtuin type 5 , Regulatory protein SIR2 homolog 5 , NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial , NAD-dependent protein deacylase sirtuin-5A, mitochondrial , regulatory protein SIR2 homolog 5-a , sirtuin (silent mating type information regulation 2 homolog) 5 , sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin 5 , nad-dependent deacetylase sirtuin-5

GENE ID SPECIES
23408 Homo sapiens
68346 Mus musculus
306840 Rattus norvegicus
420834 Gallus gallus
436878 Danio rerio
478726 Canis lupus familiaris
496346 Xenopus laevis
507347 Bos taurus
700855 Macaca mulatta
747069 Pan troglodytes
6013501 Coprinopsis cinerea okayama7130
100125966 Sus scrofa
100170199 Xenopus (Silurana) tropicalis
100173543 Pongo abelii
100528250 Ictalurus punctatus
100718110 Cavia porcellus
100339154 Oryctolagus cuniculus
100860989 Capra hircus
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