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SIRT5 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein.
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SIRT5 gene has an important regulatory role in liver carcinogenesis, and may function as a novel potential therapeutic target for HCC.
This study showed that SIRT5 supports the anaplerotic entry of glutamine (Montrer GFPT1 Kits ELISA) into the TCA cycle in malignant phenotypes of CRC (Montrer CALR Kits ELISA) via activating GLUD1 (Montrer GLUD1 Kits ELISA).
Results show that SIRT5 binds to, desuccinylates and inhibits PKM2 activity. Increased levels of reactive oxygen species (ROS) decreases succinylation and activity of PKM2 by increasing its binding to SIRT5. Moreover, inhibition of SIRT5 suppresses tumor cell proliferation through desuccinylation of PKM2 K498.
The function of the three mitochondrial sirtuins (SIRT3 (Montrer SIRT3 Kits ELISA), SIRT4 (Montrer SIRT4 Kits ELISA), SIRT5) and their role in disease are reviewed.
Our study uncovers a SIRT5-dependent mechanism that regulates cellular NADPH homeostasis and redox potential by promoting IDH2 desuccinylation and G6PD deglutarylation.
Results demonstrated presence of endogenous SIRT5 in mitochondria of cultured SH-EP cells, identified down-regulation of cellular oxidative stress by SIRT5 as one of the possible mechanisms mediating the anti-apoptotic effect of SIRT5 in SH-EP cells.
Data (including data from studies using knockout mice) suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function, particularly Complex I and Complex II; SIRT5 expression is observed in inner mitochondrial membrane of periportal hepatocytes.
a side chain-to-side chain cyclic pentapeptide harboring a central N(epsilon)-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1 (Montrer SIRT1 Kits ELISA)/2/3/6) inhibitor against human SIRT5-catalyzed deacylation reaction.
Data indicate that compared to non-neoplastic endometria (NNE (Montrer ENO1 Kits ELISA)), endometrial cancer (EC) showed SIRT7 (Montrer SIRT7 Kits ELISA) mRNA overexpression, whereas SIRT1 (Montrer SIRT1 Kits ELISA), SIRT2 (Montrer SIRT2 Kits ELISA), SIRT4 (Montrer SIRT4 Kits ELISA) and SIRT5 were underexpressed, and no significant differences were observed for SIRT3 (Montrer SIRT3 Kits ELISA) and SIRT6 (Montrer SIRT6 Kits ELISA).
Use of a pan-sirtuin (Montrer SIRT1 Kits ELISA) inhibitor and shRNA-mediated protein knockdown led us to uncover a role for the NAD(+)-dependent family of sirtuins, and in particular for SIRT2 (Montrer SIRT2 Kits ELISA) and SIRT5, in the regulation of the necroptotic cell death program
Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon (Montrer PRKCE Kits ELISA)) activation in the brain.
findings reveal a key role for SIRT5 in maintaining cardiac oxidative metabolism under pressure overload to ensure survival
Deletion of Sirt5 in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (Montrer CRMP1 Kits ELISA) and to mitochondrial fragmentation.
Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha (Montrer PPARGC1A Kits ELISA)) overexpression significantly increased the expression of sirtuin 3 (SIRT3 (Montrer SIRT3 Kits ELISA)) and sirtuin 5 (SIRT5).
In the cochlea, the expression of SIRT1 (Montrer SIRT1 Kits ELISA), 3, and 5 (both mRNA and protein) was decreased in the old mice
These findings establish that regulating heart metabolism and function is a major physiological function of lysine succinylation and SIRT5.
Myocardial ischemic reperfusion injury in Sirt5-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (Montrer SDHA Kits ELISA)), implicating alteration in SDH (Montrer SDS Kits ELISA) activity as causative of the injury.
SIRT5 has a role in cellular metabolism with a multiple enzymatic activities
Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
NAD-dependent deacetylase sirtuin-5
, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
, NAD-dependent protein deacylase sirtuin-5, mitochondrial
, SIR2-like protein 5
, regulatory protein SIR2 homolog 5
, silent mating type information regulation 2, S.cerevisiae, homolog 5
, sir2-like 5
, sirtuin type 5
, Regulatory protein SIR2 homolog 5
, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5A, mitochondrial
, NAD-dependent protein deacylase sirtuin-5A, mitochondrial
, regulatory protein SIR2 homolog 5-a
, sirtuin (silent mating type information regulation 2 homolog) 5
, sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
, sirtuin 5
, nad-dependent deacetylase sirtuin-5