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SIRT7 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. De plus, nous expédions Sirtuin 7 Kits (19) et Sirtuin 7 Protéines (15) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 149 products:
Human Polyclonal SIRT7 Primary Antibody pour IHC (p), WB - ABIN390182
Wang, Yi, Li, Cai, He, Ni, Zhou, Cheng, Jin, Fan, Qiu: Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. dans BMC cancer 2014
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Human Polyclonal SIRT7 Primary Antibody pour IHC (fro), IF (p) - ABIN760571
Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. dans Acta oto-laryngologica 2014
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Human Polyclonal SIRT7 Primary Antibody pour IF, IP - ABIN950083
Lim, Barker, Menon, Lappas: A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery. dans Biology of reproduction 2016
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Human Polyclonal SIRT7 Primary Antibody pour ICC, IF - ABIN259767
Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. dans Nucleic acids research 2016
Human Polyclonal SIRT7 Primary Antibody pour WB - ABIN4353888
Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. dans Cancer 2011
Polyclonal SIRT7 Primary Antibody pour IP - ABIN540299
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. dans Biochemical and biophysical research communications 2000
SIRT7-catalysed histone H3 (Montrer HIST3H3 Anticorps) lysine122 desuccinylation is critically implemented in DNA-damage response and cell survival.
Knockdown of SIRT7 leads to the same phenotype as depletion of DDX21 (Montrer DDX21 Anticorps) (i.e., increased formation of R loops and DNA double-strand breaks), indicating that SIRT7 and DDX21 (Montrer DDX21 Anticorps) cooperate to prevent R-loop accumulation, thus safeguarding genome integrity.
miR (Montrer MLXIP Anticorps)-3666 is an important regulator of breast cancer development. The overexpression of miR (Montrer MLXIP Anticorps)-3666 inhibits breast cancer cell proliferation by inhibiting SIRT7.
Authors evaluated the expression of known targets of miR (Montrer MLXIP Anticorps)-125a and found that sirtuin-7, matrix metalloproteinase-11 (Montrer MMP11 Anticorps), and c-Raf (Montrer RAF1 Anticorps) were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR (Montrer MLXIP Anticorps)-125a.
We found a negative correlation between mRNA levels of SIRT1 (Montrer SIRT1 Anticorps) in VAT of obese individuals and SIRT7 in VAT of the normal-weight subjects and expression of the relevant miRNAs.
Data indicate the role of SIRT7 in inhibiting SMAD4 (Montrer SMAD4 Anticorps)-mediated breast cancer metastasis providing a possible therapeutic avenue.
Energy stress strengthens SIRT7-mediated effects on Akt (Montrer AKT1 Anticorps) dephosphorylation.
The SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.
Data suggest that SIRT7 undergoes Lys (Montrer LYZ Anticorps)-63 polyubiquitination, later removed by USP7 (Montrer USP7 Anticorps) to repress enzymatic activity of SIRT7; USP7 (Montrer USP7 Anticorps) and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (Montrer G6PC Anticorps)); SIRT7 targets G6PC (Montrer G6PC Anticorps) promoter through ELK4 (Montrer ELK4 Anticorps). (SIRT7 = sirtuin 7; USP7 (Montrer USP7 Anticorps) = ubiquitin specific peptidase 7 (Montrer USP7 Anticorps); G6PC (Montrer G6PC Anticorps) = glucose-6-phosphatase catalytic subunit (Montrer G6PC Anticorps); ELK4 (Montrer ELK4 Anticorps) = transcription factor ELK4 (Montrer ELK4 Anticorps))
the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 (Montrer SMAD3 Anticorps) levels.
Data indicate that Sirt7 has a slight protective impact on both the adaptive immune system and neurogenesis. However, overall this epigenetic factor is not capable of impacting the acute or chronic phase of neuroinflammation.
Loss of SIRT7 is associated with Impairment of Adipogenesis and increased Sirt1 (Montrer SIRT1 Anticorps) Activity.
the results of our study suggest that SIRT7 is involved in protecting neurons against OGD (Montrer FGFR1 Anticorps)/R-induced injury, possibly through regulation of the p53 (Montrer TP53 Anticorps)-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.
Histological analysis revealed that there is no apparent structural abnormality of the amygdala and hippocampus, which are regions involved in fear memory consolidation, in Sirt7 KO mice. Our results indicate that SIRT7 is involved in the consolidation of fear memory.
Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (Montrer SIRT4 Anticorps) and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 (Montrer TDO2 Anticorps) and Nnmt (Montrer NNMT Anticorps)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 (Montrer TDO2 Anticorps) and Nnmt (Montrer NNMT Anticorps) may serve as markers of HFD consumption. (Tdo2 (Montrer TDO2 Anticorps) = tryptophan 2,3-dioxygenase (Montrer TDO2 Anticorps); Nnmt (Montrer NNMT Anticorps) = nicotinamide N-methyltransferase (Montrer NNMT Anticorps))
The Sirt7 mediates heterochromatin formation at rRNA genes through recruitment of DNA methyltransferase 1 (Montrer DNMT1 Anticorps) and another member of the sirtuin (Montrer SIRT1 Anticorps) family, Sirt1 (Montrer SIRT1 Anticorps).
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
These results reveal a direct role for SIRT7 in double-strand break repair and establish a functional link between SIRT7-mediated histone H3 (Montrer HIST3H3 Anticorps) K18 (Montrer KRT18 Anticorps) deacetylation and the maintenance of genome integrity.
miR (Montrer MLXIP Anticorps)-93 inhibits the metabolic target Sirt7, which we identified as a major driver of in vivo adipogenesis via induction of differentiation and maturation of early adipocyte precursors.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
, sirtuin 7
, novel protein similar to vertebratesirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) (SIRT7)
, NAD-dependent deacetylase sirtuin-7
, NAD-dependent protein deacetylase sirtuin-7
, SIR2-like protein 7
, regulatory protein SIR2 homolog 7
, silent mating type information regulation 2, S.cerevisiae, homolog 7
, sir2-related protein type 7
, sirtuin type 7
, NAD-dependent deacetylase sirtuin 7