Snail Family Zinc Finger 2 (SNAI2) Kits ELISA

Transcriptional repressor that modulates both activator- dependent and basal transcription. De plus, nous expédions Snail Family Zinc Finger 2 Anticorps (162) et Snail Family Zinc Finger 2 Protéines (10) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SNAI2 25554 O08954
SNAI2 20583 P97469
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 7.81 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests 13 to 16 Days
  96 Tests 11 to 18 Days
  96 Tests 11 to 18 Days
Boeuf (Vache)
  96 Tests 15 to 18 Days

Plus Kits ELISA pour Snail Family Zinc Finger 2 partenaires d'interaction

Mouse (Murine) Snail Family Zinc Finger 2 (SNAI2) interaction partners

  1. Study report that the Slug is highly expressed in quiescent mouse satellite cell (SCs) and functions as a direct transcriptional repressor of p16Ink4a. Loss of Slug promotes de-repression of p16Ink4a in SCs and accelerates the entry of SCs into a fully senescent state upon damage-induced stress. p16Ink4a depletion partially rescues defects in Slug-deficient SCs.

  2. Increased SNAI2 expression is associated with the development of severe pulmonary hypertension.

  3. transgenic mice expressing Slug and Kras in acinar cells were generated. Surprisingly, Slug attenuated Kras-induced acinar-ductal metaplasia (ADM)development, ERK1/2 phosphorylation and proliferation. Co-expression of Slug with Kras also attenuated chronic pancreatitis-induced changes in ADM development and fibrosis

  4. Results indicate that vimentin orchestrates the healing by controlling fibroblast proliferation, TGF-beta1-Slug signaling, and epithelial-mesenchymal transition (EMT) processing, and all of which in turn govern the required keratinocyte activation.

  5. our current findings highlight how Slug functions as an important transcriptional repressor that finely regulates the SCF/c-Kit signaling pathway.

  6. Slug emerges as a key transcription factor driving smooth muscle cell towards a proliferative phenotype.

  7. both Snail and Slug are able to form binary complexes with either YAP or TAZ that, together, control YAP/TAZ transcriptional activity and function throughout mouse development.

  8. results demonstrate that skeletal stem/stromal cell mobilize Snail/Slug-YAP/TAZ complexes to control stem cell function

  9. The data presented here demonstrate that Snai2 and Snai3 transcriptionally regulate the cellular fitness and functionality of not only CD4(+) regulatory T cells but effector CD8(alpha+) and CD4(+) conventional T cells as well.

  10. TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.

  11. Our work demonstrates the participation of SNAI2 in the pathogenesis of luminal breast cancer, and reveals an unexpected connection between the processes of postlactational involution and breast tumorigenesis in Snai2-null mutant mice.

  12. SNAI2-driven BIM-induced apoptosis may temper metastasis by governing the survival of disseminating breast tumor cells.

  13. Data indicate that deletion of snail family transcription factors Snai2 and Snai3 in bone marrow-derived cells is sufficient to induce autoantibody generation.

  14. Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.

  15. p19(Arf) (p14(ARF) in human) stabilizes Slug to inhibit E-cadherin in prostate cancer mouse models.

  16. SNAIL and SLUG probably play important roles during follicular development, luteinization and early embryonic development.

  17. Nanog functions in conjunction with mesenchymal factors Snai1 and Snai2 in the transcriptional regulation of pluripotency-associated genes and miRNAs during the Nanog-driven reprogramming process.

  18. pregnancy-associated mammary stem cells require a TGF-beta2/alphavbeta3/Slug pathway

  19. Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis.

  20. Snai2 is downregulated by glyoxal in a process that causes defective keratinocyte migration

Snail Family Zinc Finger 2 (SNAI2) profil antigène

Antigen Summary

Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.

Gene names and symbols associated with SNAI2

  • snail family transcriptional repressor 2 (Snai2) anticorps
  • snail family zinc finger 2 (Snai2) anticorps
  • Slug anticorps
  • Slugh anticorps
  • Snail2 anticorps

Protein level used designations for SNAI2

Neural crest transcription factor Slug , Protein snail homolog 2 , Slug, chicken homolog , neural crest transcription factor Slug , protein snail homolog 2 , snail family zinc finger 2 , snail homolog 2 , zinc finger protein SNAI2 , slug, chicken homolog

25554 Rattus norvegicus
100724275 Cavia porcellus
20583 Mus musculus
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