anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Anticorps

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. De plus, nous expédions Sodium Channel, Voltage-Gated, Type I, alpha Subunit Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SCN1A 20265  
SCN1A 81574 P04774
SCN1A 6323 P35498
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Top anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Anticorps sur anticorps-enligne.fr

Showing 10 out of 46 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Mammifères Souris Inconjugué ISt, IHC, WB   5 mL Connectez-vous pour afficher 2 to 6 Days
$366.67
Détails
Humain Lapin Inconjugué IHC, WB Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Nav1.1 expression in SHSY5Y (A), mouse brain (B), PC12 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB Western blot analysis of Scn1a expression in rat brain extract (lane 1), mouse brain extract (lane 2) and U87 whole cell lysates (lane 4). Scn1a at 250KD was detected using rabbit anti- Scn1a Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p) Anti-SCN1A / Nav1.1 antibody  ABIN1049319 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-SCN1A / Nav1.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Anti-SCN1A / Nav1.1 antibody IHC staining of human pancreas, exocrine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1104128 concentration 20 ug/ml. Anti-SCN1A / Nav1.1 antibody IHC of human pancreas, exocrine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. 100 μL Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Rat Souris Alkaline Phosphatase (AP) IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Connectez-vous pour afficher 11 to 12 Days
$576.53
Détails
Rat Souris APC IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Connectez-vous pour afficher 11 to 12 Days
$576.53
Détails
Rat Souris Atto 390 IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Connectez-vous pour afficher 11 to 12 Days
$576.53
Détails
Rat Souris Atto 488 IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Connectez-vous pour afficher 11 to 12 Days
$576.53
Détails
Rat Souris Atto 565 IHC, IP, WB Immunohistochemical staining of frozen sections of mouse brain extract with Scn1a monoclonal antibody, clone S74-71. 100 μg Connectez-vous pour afficher 11 to 12 Days
$576.53
Détails

SCN1A Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Anticorps mieux référencés

  1. Mammalian Monoclonal SCN1A Primary Antibody pour ISt, IHC - ABIN1304837 : Tian, Wang, Ke, Guo, Shu: Molecular identity of axonal sodium channels in human cortical pyramidal cells. dans Frontiers in cellular neuroscience 2014 (PubMed)
    Show all 31 Pubmed References

Plus d’anticorps contre Sodium Channel, Voltage-Gated, Type I, alpha Subunit partenaires d’interaction

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. Scn1a was mapped to the QTL for febrile seizure susceptibility.

  2. results therefore indicate that, while Nav1.1 is expressed in MEG (Montrer PTPN4 Anticorps)-derived inhibitory neurons, Nav1.2 (Montrer SCN2A Anticorps) is expressed in caudal (Montrer CAD Anticorps) ganglionic eminence-derived disinhibitory interneurons in addition to excitatory neurons

  3. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 (Montrer GABRA2 Anticorps) receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a+/- mice. These findings support Gabra2 (Montrer GABRA2 Anticorps) as a genetic modifier of the Scn1a+/- mouse model of Dravet syndrome.

  4. In this study, we characterized the behavior of heterozygous mice expressing the SCN1A R1648H mutation (Scn1a(RH/+)) and the effect of stress on spontaneous and induced seizures. We also examined the effect of the R1648H mutation on the hypothalamic-pituitary-adrenal (HPA (Montrer HPSE Anticorps)) axis response.

  5. findings establish an unexpected role for Nav1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain

  6. Deletion of Nav1.1 channels selectively impairs excitability of GABAergic interneurons

  7. Results show Nav1.1 haploinsufficiency in excitatory neurons has an ameliorating effect on the pathology of Dravet syndrome.

  8. These results establish a direct role for SCN1A in the regulation of sleep

  9. Loss of NaV1.1 channels in forebrain GABAergic neurons is both necessary and sufficient to cause epilepsy and premature death in Dravet syndrome.

  10. mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory; results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome

Human Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) interaction partners

  1. Study established induced pluripotent stem cells (iPSC)from two Dravet syndrome patients with different mutations in SCN1A and subsequently differentiated them into forebrain GABAergic neurons. Unique genetic alterations of SCN1A differentially impacted electrophysiological impairment of the neurons, and the impairment's extent corresponded with the symptomatic severity of the donor from which the iPSCs were derived.

  2. miR155 may be associated with the risk of seizure and SCN1A may be a target gene of miR155.

  3. we report a Chinese familial hemiplegic migraine type 3 family with a novel mutation in the SCN1A gene.

  4. The polymorphic SCN1A c.3184A>G/p.Thr1067Ala G allele was associated with a lower risk of epilepsy and a higher remission rate in Slovenian children and adolescents with epilepsy.

  5. The evaluation of an SCN1A mutation.

  6. These findings provide insight into a pharmacophore on domain IV voltage sensor through which modulation of inactivation gating can inhibit or facilitate Nav1.1 function.

  7. SCN1A rs3812718 polymorphism is a risk factor for GEFS+, and the population carrying T allele may have an increased risk of GEFS.

  8. study showed a significant association between rs6730344, rs6732655 and rs10167228 polymorphisms in the intronic regions of the SCN1A gene and refractory epilepsy, thus emerging as risk factors for drug resistance

  9. showed large-scale developmental brain changes in patients with epilepsy and SCN1A gene mutation, which may be associated with the core symptoms of the patients

  10. These data provide evidence that Nav1.1 is indeed vulnerable to deltamethrin modification at lower concentrations than Nav1.6 (Montrer SCN8A Anticorps), and this effect is primarily mediated during the resting state.

Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) profil antigène

Profil protéine

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.

Gene names and symbols associated with SCN1A

  • sodium voltage-gated channel alpha subunit 1 (SCN1A) anticorps
  • sodium voltage-gated channel alpha subunit 9 (SCN9A) anticorps
  • sodium channel, voltage-gated, type I, alpha (Scn1a) anticorps
  • sodium voltage-gated channel alpha subunit 1 (Scn1a) anticorps
  • B230332M13 anticorps
  • EIEE6 anticorps
  • FEB3 anticorps
  • FEB3A anticorps
  • FHM3 anticorps
  • GEFSP2 anticorps
  • HBSCI anticorps
  • NAC1 anticorps
  • Nav1.1 anticorps
  • SCN1 anticorps
  • SCN1A anticorps
  • SCN9A anticorps
  • SMEI anticorps

Protein level used designations for SCN1A

sodium channel, voltage-gated, type IX, alpha subunit , voltage-gated sodium channel I , sodium channel, voltage-gated, type I, alpha subunit , sodium channel protein brain I subunit alpha , sodium channel protein type 1 subunit alpha , sodium channel protein type I subunit alpha , sodium channel protein, brain I subunit alpha , sodium channel voltage-gated type I alpha polypeptide , sodium channel, voltage-gated, type 1, alpha polypeptide , sodium channel, voltage-gated, type I, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.1 , sodium channel protein, brain I alpha subunit , sodium channel voltage gated type 1 alpha subunit , sodium channel voltage-gated type I alpha

GENE ID SPECIES
100052059 Equus caballus
395946 Gallus gallus
20265 Mus musculus
81574 Rattus norvegicus
6323 Homo sapiens
478775 Canis lupus familiaris
529590 Bos taurus
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