anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Anticorps

The protein encoded by SCN10A is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit.

afficher tous les anticorps Gène GeneID UniProt
Anti-Souris SCN10A SCN10A 20264 Q6QIY3
Anti-Humain SCN10A SCN10A 6336 Q9Y5Y9
Anti-Rat SCN10A SCN10A 29571 Q62968
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Top anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit Anticorps sur anticorps-enligne.fr

Showing 10 out of 101 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC, WB IHC on paraffin sections of human appendix tissue using Rabbit antibody to Nav1.8: .HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm.Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer)Sections were counterstained with Harris Hematoxylin. IHC on paraffin sections of human brain tissue using Rabbit antibody to Nav1.8: .HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm.Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer)Sections were counterstained with Harris Hematoxylin. 100 μL Connectez-vous pour afficher 7 to 8 Days
$454.67
Détails
Humain Souris Inconjugué ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Nav1.8 Antibody (S134-12) [NBP1-47615] - Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Immunohistochemistry: Nav1.8 Antibody (S134-12) [NBP1-47615] - Mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada. 0.1 mg Connectez-vous pour afficher 8 to 11 Days
$556.31
Détails
Humain Souris Inconjugué AA, ICC, IF, IHC, WB Nav1 8 Cos1 8 transient Western Blotting. Nav1 100 μg Connectez-vous pour afficher 2 to 3 Days
$383.90
Détails
Mammifères Souris Inconjugué ISt, IHC   5 mL Connectez-vous pour afficher 2 to 6 Days
$366.67
Détails
Humain Souris HRP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$422.40
Détails
Humain Souris FITC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$426.80
Détails
Humain Souris Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$429.00
Détails
Humain Souris Biotin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$431.20
Détails
Humain Souris PE AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$432.30
Détails
Humain Souris Streptavidin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Connectez-vous pour afficher 2 to 3 Days
$433.40
Détails

anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit Anticorps mieux référencés

  1. Mammalian Monoclonal SCN10A Primary Antibody pour ISt, IHC - ABIN1304845 : François, Schüetter, Laffray, Sanguesa, Pizzoccaro, Dubel, Mantilleri, Nargeot, Noël, Wood, Moqrich, Pongs, Bourinet: The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. dans Cell reports 2015 (PubMed)
    Show all 17 Pubmed References

  2. Human Monoclonal SCN10A Primary Antibody pour AA, ICC - ABIN863135 : Dray, Read: Arthritis and pain. Future targets to control osteoarthritis pain. dans Arthritis research & therapy 2007 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre Sodium Channel, Voltage-Gated, Type X, alpha Subunit partenaires d’interaction

Mouse (Murine) Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) interaction partners

  1. Data suggests that increases in the expression of Nav1.8 channels, regulatory beta1 subunits and TNF (Montrer TNF Anticorps) receptor 1 contribute to increased nociceptor excitability and hyperalgesia in the tumor necrosis factor (Montrer TNF Anticorps) transgenic mice.

  2. that ectopic NaV1.8 expression precipitates depolarizing conduction failure in Charcot-Marie-Tooth disease

  3. While Scn10a transcripts are not detectible in ventricular cardiomyocytes, gene deletion results in reproducible loss of late sodium current under extreme experimental conditions. However, there are no identifiable consequences of this Scn10a deletion in the intact mouse heart at usual rates.

  4. Results suggest that Nav1.8 plays a role in modulating specific aspects of the retinal physiology and that starburst amacrine cells are a fundamental cellular contributor to the oscillatory potentials in mice, a clear demonstration of the dichotomy between electroretinogram b-wave and oscillatory potentials.

  5. These preclinical proof-of-concept data suggest that PF-01247324, its derivatives, or other Nav1.8-selective blockers merit further study for providing symptomatic therapy for cerebellar dysfunction in MS and related disorders.

  6. A novel splice variant of SCN10A lacking exon 11 was found in human but not detected in mouse or rat.

  7. Nav1.8 gain-of-function point mutation contributes to intense hyperexcitability along the afferent axon within distinct sensory neuron subtypes.

  8. Nav1.8 interacts with ankyrin G (Montrer ANK3 Anticorps) and they co-localize in skin nerve fibers.

  9. The enhanced NaV1.8 activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain.

  10. Analysis of BAC transgenic strains harboring an engineered deletion of the enhancer within Scn10a revealed that the enhancer was essential for Scn5a (Montrer SCN5A Anticorps) expression in cardiac tissue. SCN10A variant rs6801957 modulated Scn5a (Montrer SCN5A Anticorps) expression in the heart.

Human Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) interaction partners

  1. The possible involvement of the SCN10A variant in AF development in Chinese Han populations.

  2. Our findings suggest that there are interaction effects of DM and SCN10A (rs7375036) that influence the development of CAN.

  3. This study demonstrated that at the association and mechanistic levels, the SCN10A single nucleotide polymorphism rs6795970 biases human pain sensitivity.

  4. We investigated the association of SCN10A gene variants with 105 sporadic sudden unexplained nocturnal death syndrome victims. A total of 6 rare mutations and 16 polymorphisms were detected in SUNDS victims. This is the first report of common and rare variants of SCN10A gene in the Chinese Han population, which provides the genetic epidemiological evidence that SCN10A may be a novel susceptibility gene.

  5. Compared with Brugada syndrome (BrS) patients carrying SCN5A (Montrer SCN5A Anticorps) or CACNA1C (Montrer CACNA1C Anticorps) mutations, symptomatic patients in the SCN10A group tended to be older than those in the other gene groups. In six BrS probands who carried SCN10A variants, most experienced severe arrhythmic attacks.

  6. The p.M650K mutation shifted steady-state fast inactivation of Nav1.8 (SCN10A)to more hyperpolarized potentials and did not significantly alter any other tested gating behaviors. The AP half-width was significantly broader and the stimulated action potential firing rate was reduced for M650K transfected DRGs compared to WT.

  7. SCN10A mutations do not play primary role in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

  8. SCN10A genetic variation substantially influences functional status in patients with multiple sclerosis.

  9. SCN10A gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  10. The results demonstrate distinct properties of human Na(v)1.8, which contribute to the firing properties of human DRG neurons.

Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) profil antigène

Profil protéine

voltage-gated sodium channel that is resistant to tetrodotoxin

Gene names and symbols associated with SCN10A

  • sodium channel, voltage-gated, type X, alpha (Scn10a) anticorps
  • sodium voltage-gated channel alpha subunit 10 (SCN10A) anticorps
  • sodium voltage-gated channel alpha subunit 10 (Scn10a) anticorps
  • hPN3 anticorps
  • Na(V)1.8 anticorps
  • Nav1.8 anticorps
  • PN3 anticorps
  • SNS anticorps

Protein level used designations for SCN10A

peripheral nerve sodium channel 3 , sensory neuron sodium channel , sodium channel protein type 10 subunit alpha , sodium channel protein type X subunit alpha , voltage-gated sodium channel subunit alpha Nav1.8 , sodium channel, voltage-gated, type X, alpha polypeptide , sodium channel type X alpha polypeptide , sodium channel voltage-gated type X alpha polypeptide , sodium channel, voltage-gated, type 10, alpha polypeptide , TTX-resistant sodium channel , naNG

GENE ID SPECIES
20264 Mus musculus
6336 Homo sapiens
29571 Rattus norvegicus
477026 Canis lupus familiaris
100299477 Bos taurus
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