Sodium Leak Channel, Non-Selective Protéines (NALCN)

NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). De plus, nous expédions NALCN Anticorps (92) et beaucoup plus de produits pour cette protéine.

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NALCN 259232 Q8IZF0
NALCN 338370 Q8BXR5
Rat NALCN NALCN 266760 Q6Q760
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days

NALCN Protéines protéines par origine et source

Origin Exprimée danse Conjugué

Mouse (Murine)

Plus protéines pour Sodium Leak Channel, Non-Selective (NALCN) partenaires d'interaction

Human Sodium Leak Channel, Non-Selective (NALCN) interaction partners

  1. 4 patients with intellectual disability, small cerebellum, and contractures with novel, de novo predicted deleterious missense variants in NALCN are reported.

  2. 9-year-old male with a homozygous nonsense mutation in NALCN (c.3910C>T, p.Arg1304X) leading to profound intellectual disability, seizures, feeding difficulties, and significant periodic breathing.

  3. NALCN variant is associated with neurodevelopmental diseases.

  4. UNC80 bridges between UNC79 and the cation channel NALCN.

  5. Study identified a de novo missense mutation in NALCN, c.1768C>T, in an infant with a severe neonatal lethal form of the recently characterized congenital contractures of the limbs and face with hypotonia and developmental delay. Clinical phenotype and electrophysiologic studies show sustained muscular contraction in response to transient sensory stimuli.

  6. The present data support previous work suggesting heterozygous NALCN mutations lead to syndromic neurodevelopmental impairment.

  7. Two patients with novel mutations (p.F317C and p.V595F) and distal arthrogryposis and central hypertonicity are described.

  8. Our patients broaden the clinical spectrum associated with recessive mutations in NALCN, featuring also disrupted respiratory rhythm mimicking homozygous Nalcn knockout mice.

  9. Ohmic leak currents were identified in freshly isolated and cultured myometrial smooth muscle cells. NALCN contributes to this current. Uterine biopsies from term, non-laboring women revealed NALCN messenger RNA and protein expression in the myometrium.

  10. UNC80 encodes a large protein that is necessary for the stability and function of NALCN and for bridging NALCN to UNC79 to form a functional complex

  11. We used exome and targeted next-generation sequencing to identify de novo mutations in NALCN as the cause of a newly delineated condition, CLIFAHDD syndrome.

  12. This study found a plausible association, though not statistically confirmed, of cervical dystonia with SNPs in the NALCN region.

  13. NALCN is the gene responsible for INAD with facial dysmorphism

  14. Two mutations, one missense and one nonsense, in NALCN in two unrelated families.

  15. This study observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk.

  16. UNC80 functions as a scaffold for Src kinases in NALCN channel function.

  17. Data show the molecular basis of a muscarinic-activated inward sodium current that is independent of G-protein activation, and provide new insights into the properties of NALCN channels.

Mouse (Murine) Sodium Leak Channel, Non-Selective (NALCN) interaction partners

  1. NALCN has been identified as a core effector of inhibitory G protein-coupled receptors.

  2. The authors discovered that substantia nigra pars reticulata neurons express the sodium leak channel, NALCN, and that neurons lacking NALCN have impaired spontaneous firing. In addition, NALCN is involved in the modulation of excitability by changes in glycolysis and by activation of muscarinic acetylcholine receptors.

  3. We show here that Nalcn, a unique channel that generates "leak" sodium currents, regulates excitability and neuromodulation of RTN neurons and CO2-stimulated breathing. Thus, this work defines a specific function for this enigmatic channel in an important physiological context.

  4. results substantiate the use of a forward-genetics approach for studying sleep behaviours in mice, and demonstrate the role of SIK3 and NALCN in regulating the amount of NREMS and REMS, respectively

  5. NALCN is involved in the substance P-induced depolarization of intestinal pacemaking activity in interstitial cells of Cajal.

  6. Study demonstrates that Nalcn associates with serum sodium concentrations in mice and indicates that Nalcn is an important novel player in osmoregulation.

  7. NALCN ion channel is a new actor in pancreatic beta-cell physiology.

  8. Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-unc-80 homolog (C. elegans) protein-non-selective protein voltage gated channel like 1 complex in a G protein-dependent fashion

  9. Unlike any of the other 20 family members, NALCN forms a voltage-independent, nonselective cation channel; NALCN mutant mice have a severely disrupted respiratory rhythm and die within 24 hours of birth.

  10. findings identify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src family kinases, rather than a G protein, are involved in the coupling from receptor to channel

Profil protéine NALCN

Profil protéine

NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007

Gene names and symbols associated with NALCN

  • sodium leak channel, non-selective (NALCN)
  • sodium leak channel, non-selective (nalcn)
  • sodium leak channel, non-selective (Nalcn)
  • A530023G15Rik Protéine
  • AI849508 Protéine
  • bA430M15.1 Protéine
  • CanIon Protéine
  • Vgcnl1 Protéine
  • zgc:113349 Protéine

Protein level used designations for NALCN

sodium leak channel, non-selective , voltage gated channel like 1 , sodium leak channel non-selective protein , four repeat voltage-gated ion channel , voltage gated channel-like protein 1 , brain voltage-gated cation channel , four domain-type voltage-gated ion channel alpha-1 subunit

418770 Gallus gallus
452643 Pan troglodytes
485535 Canis lupus familiaris
536103 Bos taurus
548345 Danio rerio
100019011 Monodelphis domestica
100062714 Equus caballus
100083068 Ornithorhynchus anatinus
100358614 Oryctolagus cuniculus
100471662 Ailuropoda melanoleuca
100525356 Sus scrofa
100551926 Anolis carolinensis
100592455 Nomascus leucogenys
259232 Homo sapiens
338370 Mus musculus
266760 Rattus norvegicus
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