anti-Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) Anticorps

SLC15A1 encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. De plus, nous expédions SLC15A1 Protéines (6) et SLC15A1 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SLC15A1 6564 P46059
SLC15A1 56643 Q9JIP7
SLC15A1 117261 P51574
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Top anti-SLC15A1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 78 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB Western blot analysis of PEPT1 expression in Jurkat (A), SP2/0 (B), PC12 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB ABIN6275331 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod Western blot analysis of extracts from various samples, using SLC15A1 Antibody. Lane 1: Hela  treated with  blocking peptide; Lane 2: hela; Lane 3: mouse kidney; 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 50 μg 6 to 8 Days
$495.00
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SLC15A1 antibody ABIN290273 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-SLC15A1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg 11 to 14 Days
$484.00
Détails
Poulet Lapin Inconjugué FACS, IF (cc), IF (p), IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti PEPT1 Polyclonal Antibody, Unconjugated (ABIN671961) at 1:200 followed by conjugation to the secondary antibody and DAB staining HCCLM3 cells probed with Rabbit Anti-PEPT1 Polyclonal Antibody, Unconjugated  at 1:100 for 30 minutes followed by incubation with a conjugated secondary -FITC) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange). 100 μL 3 to 7 Days
$329.45
Détails
Humain Lapin Inconjugué WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB Mouse lung lysates probed with Rabbit Anti-PEPT1 Polyclonal Antibody, Unconjugated (ABIN2559661) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 for 90min at 37˚C. 100 μL 3 to 7 Days
$317.90
Détails
Humain Lapin Inconjugué IHC, WB 100 μL 11 to 14 Days
$419.83
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg 2 to 3 Days
$302.50
Détails

anti-SLC15A1 Anticorps mieux référencés

  1. Chicken Polyclonal SLC15A1 Primary Antibody pour FACS, IF (cc) - ABIN671961 : Xu, Wu, Liu, Xie, Huang, Liu: Establishment and characterization of an omasal epithelial cell model derived from dairy calves for the study of small peptide absorption. dans PLoS ONE 2014 (PubMed)

Plus d’anticorps contre SLC15A1 partenaires d’interaction

Pig (Porcine) Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. PepT1 mRNA expression in the distal jejunum increased gradually with age in suckling Tibetan piglet

Human Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. PepT1 could serve as a desirable target for oral nanoparticulate drug delivery.

  2. REVIEW: summarizes the progress made in the regulation of PepT1 and provides insights into the PepT1's potential in clinical aspects of nutritional and drug therapies

  3. Although small intestinal PEPT1 expression tended to be lower in neonates than in older children, this difference is small and tissue distribution is similar. This finding suggests similar oral absorption of PEPT1 substrates across the pediatric age range.

  4. PEPT1 overexpression is associated with pancreatic cancer.

  5. Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.

  6. Phe-Psi-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1.

  7. miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.

  8. OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane

  9. The PEPT1 rs2297322 single-nucleotide polymorphism was not associated with inflammatory bowel disease susceptibility in our German cohort.

  10. Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, could play a crucial role in cell-to-cell communication during colitis

  11. The present review summarizes the recent knowledge on the factors modulating PEPT1 expression/function in Caenorhabditis elegans, Danio rerio, Mus musculus and Homo sapiens, with focus on dietary ingredients, transcription factors and modulators.[review]

  12. promoter constructs were generated and cotransfected with an Nrf2 expression plasmid

  13. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.

  14. The induction of PEPT1 gene and the suppression of ABCG2 gene expression are among the key molecular mechanisms underlying tumor-specific PpIX accumulation after the administration of ALA in bladder cancer.

  15. These studies unequivocally demonstrate the presence of PEPT1 protein in healthy distal colonic epithelium in mice, rats, and humans and proved that the protein is functional and contributes to electrolyte and water handling in mice.

  16. PC-3 demonstrates strong expression of PEPT1 and PHT1.

  17. that Pept1(-/-) mice lack the adaptation of the upper small intestinal mucosa to the trophic effects of the diet

  18. High affinity of NP-647 toward PEPT1 binding site as compared to TRH.

  19. PEPT1 and ABCG2 are key players in regulating intracellular PpIX levels and determining the efficacy of ALA-based photocytotoxicity against gastric cancer cells in vitro.

  20. The PepT1-NOD2 signaling pathway is involved in aggravation of colitis in mice.

Mouse (Murine) Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. Results suggest that PepT1 contributes to maintain balance of homeostasis and proper functions in the small intestine, and dysregulated miRNAs and proteins along the crypt-villus axis are highly related to this process.

  2. Glycosylation of PEPT1 confers resistance against proteolytic cleavage by proteinase K, whereas a remarkable intrinsic stability against trypsin, even in the absence of N-linked glycans, was detected.

  3. We tested the hypothesis that PEPT2 genotypes affect the severity and prognosis of porphyria-associated kidney disease

  4. findings suggested a major role of PEPT1 in the intestinal permeability and oral absorption of 5-aminolevulinic acid

  5. Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.

  6. Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.

  7. miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.

  8. PEPT1 expression is reduced during intestinal inflammation and PEPT1 is not required for muramyl dipeptide-induced immune response.

  9. Data indicate that peroxisome proliferator-activated receptor-alpha (PPARalpha) activated the intestinal expression of Slc15a1 mRNA during the light period, and protein levels of PepT1 peaked before the start of the dark phase.

  10. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.

  11. PepT1 deletion reduced the area under the plasma concentration-time profile (AUC0-120) of cefadroxil by 10-fold, the maximum plasma concentration (Cmax) by 17.5-fold, and increased the time to reach a maximum plasma concentration (Tmax) by 3-fold.

  12. A critical role of intestinal PepT1 in improving the rate and extent of oral absorption for valacyclovir.

  13. PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis.

  14. These studies unequivocally demonstrate the presence of PEPT1 protein in healthy distal colonic epithelium in mice, rats, and humans and proved that the protein is functional and contributes to electrolyte and water handling in mice.

  15. Intestinal PepT1 has a major influence in improving the oral absorption of valacyclovir.

  16. The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet.

  17. Expression of PEPT1 protein in the small intestine was increased ~2-fold in wild-type mice during fasted as compared to fed conditions.

  18. PEPT1 is important for overall amino acid absorption only after high dietary protein intake when amino acid transport processes are saturated and PEPT1 can provide additional absorption capacity.

  19. Compared with wild-type animals, PEPT1 null mice exhibited a 78% reduction in glycylsarcosine uptake at pH 6.0 at 37 degrees C.

  20. Results from this study indicated that treatment with Lactobacillus plantarum may ameliorate colonic epithelial barrier dysfunction in IL-10 knockout mice, by modulating the apical junction complex and PepT1-mediated transport.

Cow (Bovine) Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. The PepT1 profile and expression in gastrointestinal epithelial cells of yak varied from those of cattle, implying that yak have evolved a peptide transport mechanism to adapt the environment of the Qinghai-Tibetan plateau.

Rabbit Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. Real time-PCR results indicated that SLC15A1, SLC7A1 and SLC1A1 genes throughout the rabbits' entire development and were expressed in all tested rabbit digestive sites, including the stomach, duodenum, jejunum, ileum, colon and cecum.

  2. beta-Klotho participates in the regulation of the peptide transporters PEPT1 and PEPT2.

  3. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2.

  4. SPAK is a powerful regulator of peptide transporters PEPT1 and PEPT2

  5. Appropriate amino acid substitutions of Arg(282) and Asp(341) change the properties of PepT1 in a way that confirms that these parts of the protein act as an electrostatic gate in the transport process.

  6. Report PepT1 kinetics in vitro and using computer simulated kinetic models.

  7. The role of conserved tyrosines in the transmembrane domains (TMDs) of rabbit PepT1 as predicted by hydropathy plots, was investigated.

  8. Mutation of rabbit PepT1 arginine282 R282E- and R282D-PepT1 showed an increased charge:peptide stoichiometry over the wild-type 1:1 ratio for the neutral dipeptide Gly-l-Gln, measured using two-electrode voltage clamp.

  9. Report substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.

Zebrafish Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 (SLC15A1) interaction partners

  1. These results suggest that PepT1 may be a contributing mechanism to compensatory growth that could influence cholecystokinin secretion and gastrin-releasing peptide and ghrelin activity.

  2. Report PepT1 kinetics in vitro and using computer simulated kinetic models.

  3. PEPT1 maximal transport rates unexpectedly increase at alkaline extracellular pH; pept1 is highly expressed in the proximal intestine since day 4 post-fertilisation, preceding functional maturation of the gut

SLC15A1 profil antigène

Profil protéine

This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.

Gene names and symbols associated with SLC15A1

  • solute carrier family 15 member 1 (SLC15A1) anticorps
  • solute carrier family 15 (oligopeptide transporter), member 1 (slc15a1) anticorps
  • solute carrier family 15 member 1 (slc15a1) anticorps
  • solute carrier family 15 (oligopeptide transporter), member 1 (Slc15a1) anticorps
  • solute carrier family 15 member 1 (Slc15a1) anticorps
  • solute carrier family 15 (oligopeptide transporter), member 1b (slc15a1b) anticorps
  • D630032F02 anticorps
  • fd47f07 anticorps
  • HPECT1 anticorps
  • HPEPT1 anticorps
  • PECT1 anticorps
  • PEPT-1 anticorps
  • Pept1 anticorps
  • slc15a1 anticorps
  • wu:fd47f07 anticorps

Protein level used designations for SLC15A1

peptide transporter 1 , solute carrier family 15 member 1 , solute carrier family 15 (oligopeptide transporter), member 1 , proton-dependent dipeptide transporter PEPT1 , solute carrier family 15 member 1-like , Caco-2 oligopeptide transporter , intestinal H+/peptide cotransporter , macrophage oligopeptide transporter PEPT1 , oligopeptide transporter, small intestine isoform , intestinal H(+)/peptide cotransporter , intestinal peptide transporter PEPT1 , proton-coupled dipeptide cotransporter , peptide transporter PepT1 , proton-dependent gastrointestinal peptide transporter 1 , pineal gland-specific PEPT1 , proton-coupled peptide cotransporter PepT1

GENE ID SPECIES
397624 Sus scrofa
467307 Pan troglodytes
574257 Macaca mulatta
100145353 Xenopus (Silurana) tropicalis
100450526 Pongo abelii
100565958 Anolis carolinensis
100582457 Nomascus leucogenys
100219866 Taeniopygia guttata
6564 Homo sapiens
56643 Mus musculus
378789 Gallus gallus
521181 Bos taurus
117261 Rattus norvegicus
403561 Canis lupus familiaris
100009186 Oryctolagus cuniculus
793301 Danio rerio
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