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The protein encoded by SLC17A3 is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004).
hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner.
variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of para-aminohippurate, bumetanide, estrone and urate; SNPs may contribute to inter-individual differences in disposition of anionic drugs and certain endogenous organic anions
Genetic variants within SLC2A9,ABCG2 and SLC17A3 are associated with uric acid levels
a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4.
SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation.
mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex
The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.
sodium-dependent phosphate transport protein 4
, Na/Pi cotransporter 4
, sodium-phosphate cotransporter
, solute carrier family 17 (sodium phosphate), member 3
, Na(+)/PI cotransporter 4
, sodium/phosphate cotransporter 4