anti-Solute Carrier Family 2 (Facilitated Glucose/fructose Transporter), Member 5 (SLC2A5) Anticorps

Human Solute Carrier Family 2 (Facilitated Glucose/fructose Transporter), Member 5 (SLC2A5) interaction partners

1. It was found that SLC2A5, which encodes solute carrier family 2 member 5 (SLC2A5, previously termed GLUT5) facilitates cell fructose uptake and was up-regulated in Philadelphia chromosome-positive ALL.

2. High expression of SLC2A5 in SUP-B15/R acute lymphoblastic leukemia cells leads to increased fructose absorption, and further activates PI3K/AKT pathway which cause the SUP-B15 cell resistance to imatinib.

3. Besides GLUT1, GLUT5 seems to be regulated under hypoxia.

4. identified amino acid residues of GLUT5 that define its substrate specificity for glucose transporter 5 (GLUT5)-mediated fructose transport.

5. fructose can be used by glioma cells, and restrict the fructose intake or targeting GLUT5 could be efficacious strategies in glioma.

6. SLC2A5-inhibits the human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network.

7. SGLT1 and GLUT5 expression in the plasma membrane is regulated by TNFalpha, leading to alteration on sugar transport, suggesting that TNFalpha could be a physiological local regulator of nutrient absorption in response to an intestinal inflammatory status.

8. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.

9. [(99m)Tc]GLA uptake is related to GLUT-5 transporter expression and transport

10. In high grade prostatic intraepithelial neoplasia, Glut-1 was immunohistochemically undetectable and Glut-5 localized to the apical portion of the plasma membrane of the hyper-proliferative cells

11. A role for the GLUT5 isoform in fructose uptake that takes place in clear renal cell carcinoma cells and which subsequently leads to the malignant progression.

12. these results suggest that methylation of histone H3 at K4 and acetylation of histones H3 and H4 are involved in SLC2A5 gene induction associated with intestinal differentiation of Caco-2 cells.

13. Fructose modulation of GLUT5 mRNA stability via cyclic AMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.

14. Differentiation of THP-1 monocytes into macrophages was associated with marked induction of GLUT 3 and GLUT 5 protein expression, and high levels of GLUT 1, GLUT 3, and GLUT 5 were maintained after transformation to foam cells.

15. GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers

16. GLUT5 expression is dramatically increased in diabetic muscle and pioglitazone treatment reverses this overexpression.

17. These results suggest that inactivation of p44/42 MAPK enhances T(3)-induced GLUT5 gene expression in Caco-2 cells through increasing TRalpha-1 transactivity and binding activity to the GLUT5-TRE, probably due to de-phosphorylation of TRalpha-1.

18. De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells.

19. These results suggest that the histone H3 di-methylation at lysine 9, as well as acetylation at lysine 9/14, may be indispensable for coordinated induction of the GLUT5 gene by p44/42 MAP kinase inhibition and the glucocorticoid hormone.

20. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension.

Mouse (Murine) Solute Carrier Family 2 (Facilitated Glucose/fructose Transporter), Member 5 (SLC2A5) interaction partners

1. identified amino acid residues of GLUT5 that define its substrate specificity for glucose transporter 5 (GLUT5)-mediated fructose transport.

2. GLUT5 activity contributes to antipsychotic-induced weight gain.

3. Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.

4. Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5, probably by endogenous synthesis of fructose.

5. Fructose and GluT5 play an important role in regulating adipose differentiation.

6. regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents

7. We conclude that Glut5 is not required for OHC motility or cochlear amplification.

8. The essential role of chloride and fructose absorbing Slc2a5 is reported.

9. mRNA expression of GLUT5 varied diurnally in the duodenum, jejunum and ileum mucosa. GLUT5 protein level varied diurnally in duodenum and jejunum, but not in the ileum.

10. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension.

Cow (Bovine) Solute Carrier Family 2 (Facilitated Glucose/fructose Transporter), Member 5 (SLC2A5) interaction partners

1. crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively