anti-Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) Anticorps

The protein encoded by SLC22A12 is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. De plus, nous expédions Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Kits (7) et Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SLC22A12 20521 Q8CFZ5
SLC22A12 116085 Q96S37
SLC22A12 365398 Q3ZAV1
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Top anti-Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Anticorps sur anticorps-enligne.fr

Showing 10 out of 37 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-SLC22A12 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  DU145 cell lysate 100 μL 2 to 3 Days
$319.00
Détails
Humain Lapin Inconjugué WB 100 μL 11 to 14 Days
$581.17
Détails
Humain Lapin Inconjugué IHC, WB ABIN6273184 at 1/100 staining Human lymph cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of PC-13 cells, using URAT1 antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using SLC22A12 antibody (ABIN1874812) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. 100 μL 11 to 13 Days
$366.77
Détails
Humain Souris Inconjugué ELISA, WB SLC22A12 monoclonal antibody (M02), clone 2B5. Western Blot analysis of SLC22A12 expression in human stomach. Detection limit for recombinant GST tagged SLC22A12 is 0.3 ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué ELISA, WB   100 μL 11 to 14 Days
$1,079.83
Détails
Humain Lapin Inconjugué WB Western Blot analysis of SLC22A12 expression in transfected 293T cell line by SLC22A12 MaxPab polyclonal antibody.Lane 1: SLC22A12 transfected lysate(59.60 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Détails
Humain Lapin Inconjugué WB SLC22A12 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Détails
Humain Lapin Inconjugué IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with SLC22A12 polyclonal antibody  shows strong membranous positivity in cells in tubules. 100 μL 11 to 12 Days
$577.33
Détails
Humain Lapin Inconjugué ELISA, WB   100 μL 11 to 16 Days
$787.29
Détails

anti-Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 Anticorps mieux référencés

  1. Human Monoclonal SLC22A12 Primary Antibody pour ELISA, WB - ABIN530376 : Roncal-Jimenez, Lanaspa, Rivard, Nakagawa, Sanchez-Lozada, Jalal, Andres-Hernando, Tanabe, Madero, Li, Cicerchi, Mc Fann, Sautin, Johnson: Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. dans Metabolism: clinical and experimental 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SLC22A12 Primary Antibody pour WB - ABIN5664956 : Liu, Yuan, Zhou, Zhao, Chen, Cheng, Lu, Liu: Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. dans Journal of cellular and molecular medicine 2018 (PubMed)

Plus d’anticorps contre Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 partenaires d’interaction

Mouse (Murine) Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) interaction partners

  1. Urat1-Uox double knockout mice are a suitable animal model for renal hypouricemia.

  2. Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1, ABCG2, and URAT1. Immunostaining for GLUT9 was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.

  3. The cause of obesity/metabolic syndrome-associated hyperuricemia appears to be associated with the urate reabsorption transporter Urat1 protein enhanced by fat.

  4. Although the fractional excretion of urate of knockout mice was tend to higher than that of wildtype mice, the urate reabsorption ability remained in the kidney of knockout mice, indicating a urate reabsorptive transporter other than Urat1.

  5. mouse RST mediates the efflux of organic anions including urate and works as exit for organic anions in the proximal tubules

  6. NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the brush Border membrane abundance of mURAT1.

Human Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) interaction partners

  1. Letter/Case Report: hereditary renal hypouricaemia combined with Fanconi syndrome caused by URAT1 mutation.

  2. Low URAT1 expression is associated with hypophosphatemia in calcium stone formers.

  3. these results suggest that ABCG2 rs72552713 and SLC22A12 rs11231825 are likely associated with gout in the Vietnamese population in which T allele may be a risk factor for gout susceptibility.

  4. Which was caused by compound heterozygous mutations of the SLC22A12 gene.

  5. This is the first identification of a family with mild renal hypouricemia1 associated to the p.T467 M variant. The sequencing analysis of SLC22A12 revealed a potentially deleterious missense variant c.1400C > T (p.T467 M, rs200104135) in heterozygous state.

  6. Findings provide new insights into the genetic architecture of serum urate, and highlight molecular targets in SLC22A12 and SLC2A9 for lowering serum urate and preventing gout.

  7. URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia

  8. The rs475688 polymorphism is associated with gout susceptibility. The correlation between rs3825016 polymorphism of SLC22A12 and hyperuricaemia susceptibility is possible. [Meta-Analysis]

  9. Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout.

  10. Human-rat transporter chimeras revealed that human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are necessary and sufficient to provide up to a 100-fold increase in affinity for inhibitors. Moreover, serine-35 and phenylalanine-365 are important for high-affinity interaction with the substrate urate.

  11. Immunoreactivity of URAT1 was observed on the basolateral side of the cytoplasm of epithelial cells in the choroid plexus.

  12. A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level.

  13. The present proof-of-principle paper demonstrates that the multilocus profiles of ABCG2, SLC2A9 and SLC22A12 increase susceptibility to asymptomatic hyperuricaemia, gout and tophi.

  14. The common dysfunction allelic variants of URAT1 exist in the general Roma population and thus renal hypouricemia should be kept in differential diagnostic algorithm on Roma patients with defect in renal tubular urate transport.

  15. novel variants p.R92C and p.R203C associated with renal hypouricemia type 1

  16. URAT1 nonfunctional variants are protective genetic factors for gout/hyperuricemia, and also demonstrated the sex-dependent effect size of these URAT1 variants on serum uric acid (P for interaction = 1.5 x 10(-12)).

  17. c.1245_1253del and c.1400C>T variants present in the Czech and Slovak Roma population at unexpectedly high frequencies

  18. These results suggest that URAT1 rs3825016 and rs1529909 polymorphisms influence the uricosuric action of losartan

  19. Depletion of UA due to SLC22A12/URAT1 loss-of-function mutations causes endothelial dysfunction in hypouricemia patients.

  20. not only loss-of-function mutation of URAT1 but also the dominant-negative effect cause RHUC through loss of UA absorption, partly due to protein misfolding caused by accumulation of URAT1 protein in the endoplasmic reticulum

Solute Carrier Family 22 (Organic Anion/urate Transporter), Member 12 (SLC22A12) profil antigène

Profil protéine

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SLC22A12

  • solute carrier family 22 (organic anion/cation transporter), member 12 (Slc22a12) anticorps
  • solute carrier family 22 member 12 (SLC22A12) anticorps
  • solute carrier family 22 member 12 (Slc22a12) anticorps
  • AI987855 anticorps
  • OAT4L anticorps
  • RST anticorps
  • Slc22al2 anticorps
  • URAT1 anticorps

Protein level used designations for SLC22A12

renal-specific transporter , solute carrier family 22 (organic cation transporter)-like 2 , solute carrier family 22 member 12 , urate anion exchanger 1 , organic anion transporter 4-like protein , solute carrier family 22 (organic anion/cation transporter), member 12 , urate transporter 1

GENE ID SPECIES
20521 Mus musculus
116085 Homo sapiens
365398 Rattus norvegicus
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