Solute Carrier Family 22 Member 5 Protéines (SLC22A5)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. De plus, nous expédions SLC22A5 Anticorps (35) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SLC22A5 6584 O76082
SLC22A5 20520 Q9Z0E8
Rat SLC22A5 SLC22A5 29726 O70594
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Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$225.40
Détails

SLC22A5 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,
,

Plus protéines pour Solute Carrier Family 22 Member 5 (SLC22A5) partenaires d'interaction

Human Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. When endogenous OCTN2-mediated colistin transport was inhibited by co-incubation with L-carnitine, primary mouse proximal tubular cells were fully protected from colistin toxicity

  2. The OCTN2 carnitine transporter is essential for retaining carnitine in the body and allowing adequate supplies to the heart and the skeletal muscle, which derive most of their energy from fat. Mutations impairing its function result in carnitine deficiency that can present early in life with hypoketotic hypoglycemia, or later in life with cardiomyopathy and sudden death from cardiac arrhythmia. Review.

  3. A homozygous stop variant in the SLC22A5 gene in a family with cardiomyopathy and sudden death history.

  4. Elucidation of GM-CSF (Montrer CSF2 Protéines) signaling demonstrates that the cytokine causes the activation of mTOR (Montrer FRAP1 Protéines) kinase, leading to the phosphorylation and activation of STAT3 (Montrer STAT3 Protéines), which, in turn, is responsible for OCTN2 transcription.

  5. dissociation of bound substrate from the transporter is rate limiting in establishing maximal rates of OCT2-mediated transport

  6. It is postulated that ZO-1 (Montrer TJP1 Protéines), when not phosphorylated by PKC (Montrer PRRT2 Protéines), keeps Octn2 in an active state, while elimination of this binding in DeltaPDZ mutant or after ZO-1 (Montrer TJP1 Protéines) phosphorylation leads to diminution of Octn2 activity.

  7. Results confirmed the diagnosis of eight patients with systemic primary carnitine deficiency (CDSP) on the gene level, including six mutations found in the solute carrier family 22 member 5 (SLC22A5) gene.

  8. Our results suggest that a common promoter haplotype of OCTN2 regulates the transcriptional rate of OCTN2 and influences the clinical course of CD.

  9. The local genotype influences methylation levels at SLC22A5 and ZPBP2 (Montrer ZPBP2 Protéines) promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA (Montrer GSDMA Protéines)-ZPBP2 (Montrer ZPBP2 Protéines) and SLC22A5 methylation and asthma in females and males separately.

  10. The results of the current study demonstrated that -207C>G polymorphism of the SLC22A5 gene is not associated with male infertility.

Mouse (Murine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Both mRNA and protein levels of OCTN2 were detected in kidney after exercise and during recovery, suggesting renal transport mechanisms were stimulated. These changes were accompanied with a reciprocal increase in PPARalpha (Montrer PPARA Protéines) protein expression.

  2. There was increased apoptosis in gut (Montrer GUSB Protéines) samples from OCTN2(-/-) mice.

  3. Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma (Montrer PPARG Protéines) in humans and mice and contributes to local and systemic carnitine homeostasis.

  4. OCTN2, a transporter that is thought to be responsible for the accumulation of L-carnitine in the epididymal lumen, is regulated in response to changes in tonicity.

  5. Mouse OCTN2 is a direct target gene of PPARalpha (Montrer PPARA Protéines) and transcriptional upregulation of OCTN2 by PPARalpha (Montrer PPARA Protéines) is likely mediated via PPRE1 in its first intron.

  6. acetyl-L-carnitine is transported from blood to brain extracellular fluid by OCTN2

  7. placental OCTN2 is obligatory for accumulation of carnitine in placenta & fetus, fatty acid beta-oxidation enzymes are expressed in placenta & reduced carnitine levels upregulate expression of short-chain L-3-hydroxyacyl CoA dehydrogenase (Montrer HSD17B10 Protéines) in placenta

  8. Novel OCTN2 in mouse pancreas.

  9. OCTN2 functions as a carnitine transporter between the epithelium and the lumen in distal corpus and cauda epididymides and provides a clue as to why obstructive azoospermia is induced in distal parts of epididymis.

  10. These findings indicate that OCTN2 is predominantly responsible for the uptake of carnitine from the apical surface of mouse small intestinal epithelial cells.

Cow (Bovine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 (Montrer POU2F1 Protéines) and OCT-2 (Montrer SLC22A2 Protéines). OCT-2 (Montrer SLC22A2 Protéines) was localized in the epithelial and submucosal regions of the nasal olfactory and respiratory mucosa

Profil protéine SLC22A5

Profil protéine

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Gene names and symbols associated with SLC22A5

  • solute carrier family 22 member 5 (SLC22A5)
  • solute carrier family 22 (organic cation transporter), member 5 (Slc22a5)
  • solute carrier family 22 member 5 (LOC100358417)
  • solute carrier family 22 member 5 L homeolog (slc22a5.L)
  • solute carrier family 22 member 5 (Slc22a5)
  • organic cation/carnitine transporter 2 (OCT2)
  • ATOCT2 Protéine
  • CDSP Protéine
  • CT1 Protéine
  • jvs Protéine
  • Lstpl Protéine
  • MGC68932 Protéine
  • OCT2 Protéine
  • Octn2 Protéine
  • OCTN2VT Protéine
  • organic cation/carnitine transporter 2 Protéine
  • ORGANIC CATION TRANSPORTER 2 Protéine
  • slc22a5 Protéine
  • UST2r Protéine
  • YUP8H12R.2 Protéine
  • YUP8H12R_2 Protéine

Protein level used designations for SLC22A5

high-affinity sodium dependent carnitine cotransporter , organic cation/carnitine transporter 2 , solute carrier family 22 member 5 , high-affinity sodium-dependent carnitine cotransporter , juvenile visceral steatosis , solute carrier family 22 (organic cation/carnitine transporter), member 5 , solute carrier family 22 (organic cation transporter), member 5 , solute carrier family 22, member 5 , high-affinity carnitine transporter , integral membrane transport protein

GENE ID SPECIES
6584 Homo sapiens
20520 Mus musculus
416328 Gallus gallus
541266 Bos taurus
100137218 Papio anubis
100358417 Oryctolagus cuniculus
380592 Xenopus laevis
29726 Rattus norvegicus
608146 Canis lupus familiaris
100072871 Equus caballus
100520422 Sus scrofa
844274 Arabidopsis thaliana
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