Solute Carrier Family 22 Member 5 Protéines (SLC22A5)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. De plus, nous expédions SLC22A5 Anticorps (35) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SLC22A5 6584 O76082
SLC22A5 20520 Q9Z0E8
Rat SLC22A5 SLC22A5 29726 O70594
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Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$221.48
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SLC22A5 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,
,

Plus protéines pour Solute Carrier Family 22 Member 5 (SLC22A5) partenaires d'interaction

Human Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. When endogenous OCTN2-mediated colistin transport was inhibited by co-incubation with L-carnitine, primary mouse proximal tubular cells were fully protected from colistin toxicity

  2. The OCTN2 carnitine transporter is essential for retaining carnitine in the body and allowing adequate supplies to the heart and the skeletal muscle, which derive most of their energy from fat. Mutations impairing its function result in carnitine deficiency that can present early in life with hypoketotic hypoglycemia, or later in life with cardiomyopathy and sudden death from cardiac arrhythmia. Review.

  3. A homozygous stop variant in the SLC22A5 gene in a family with cardiomyopathy and sudden death history.

  4. Elucidation of GM-CSF signaling demonstrates that the cytokine causes the activation of mTOR kinase, leading to the phosphorylation and activation of STAT3, which, in turn, is responsible for OCTN2 transcription.

  5. dissociation of bound substrate from the transporter is rate limiting in establishing maximal rates of OCT2-mediated transport

  6. It is postulated that ZO-1, when not phosphorylated by PKC, keeps Octn2 in an active state, while elimination of this binding in DeltaPDZ mutant or after ZO-1 phosphorylation leads to diminution of Octn2 activity.

  7. Results confirmed the diagnosis of eight patients with systemic primary carnitine deficiency (CDSP) on the gene level, including six mutations found in the solute carrier family 22 member 5 (SLC22A5) gene.

  8. Our results suggest that a common promoter haplotype of OCTN2 regulates the transcriptional rate of OCTN2 and influences the clinical course of CD.

  9. The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately.

  10. The results of the current study demonstrated that -207C>G polymorphism of the SLC22A5 gene is not associated with male infertility.

  11. Functional activity of L-carnitine transporters in human airway epithelial cells.

  12. c.760C>T (p.R254X) mutation of the SLC22A5 gene is associated with the primary carnitine deficiency.

  13. Human OCTN2 expression is directly regulated by PPAR-alpha.

  14. Nine novel SLC22A5 gene mutations were identified and characterized in Chinese patients with Systemic primary carnitine deficiency CDSP. The R254X mutation was the most frequent, and it could likely be an ethnic founder mutation.

  15. A novel in-frame deletion (p.F23del), and a novel nonsense mutation (p.Q180X) result in primary carnitine deficiency.

  16. Mutation analysis of the gene SLC22A5 confirms the diagnosis of primary systemic carnitine deficiency.

  17. OCTN2 is involved in L-carnitine transport at the human BBB.

  18. Mutations in SLC22A5 and ETFDH are associated with riboflavin responsive-multiple acyl-CoA dehydrogenase deficiency.

  19. promoter methylation is responsible for epigenetic down-regulation of OCTN2 in HepG2 and LS174T cells.

  20. The OCTN2 transporter is generally down-regulated in virus and nonvirus-mediated epithelial cancers, probably via methylation of its promoter region.

Cow (Bovine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 and OCT-2. OCT-2 was localized in the epithelial and submucosal regions of the nasal olfactory and respiratory mucosa

Profil protéine SLC22A5

Profil protéine

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Gene names and symbols associated with SLC22A5

  • solute carrier family 22 member 5 (SLC22A5)
  • solute carrier family 22 (organic cation transporter), member 5 (Slc22a5)
  • solute carrier family 22 member 5 (LOC100358417)
  • solute carrier family 22 member 5 L homeolog (slc22a5.L)
  • solute carrier family 22 member 5 (Slc22a5)
  • organic cation/carnitine transporter 2 (OCT2)
  • ATOCT2 Protéine
  • CDSP Protéine
  • CT1 Protéine
  • jvs Protéine
  • Lstpl Protéine
  • MGC68932 Protéine
  • OCT2 Protéine
  • Octn2 Protéine
  • OCTN2VT Protéine
  • organic cation/carnitine transporter 2 Protéine
  • ORGANIC CATION TRANSPORTER 2 Protéine
  • slc22a5 Protéine
  • UST2r Protéine
  • YUP8H12R.2 Protéine
  • YUP8H12R_2 Protéine

Protein level used designations for SLC22A5

high-affinity sodium dependent carnitine cotransporter , organic cation/carnitine transporter 2 , solute carrier family 22 member 5 , high-affinity sodium-dependent carnitine cotransporter , juvenile visceral steatosis , solute carrier family 22 (organic cation/carnitine transporter), member 5 , solute carrier family 22 (organic cation transporter), member 5 , solute carrier family 22, member 5 , high-affinity carnitine transporter , integral membrane transport protein

GENE ID SPECIES
6584 Homo sapiens
20520 Mus musculus
416328 Gallus gallus
541266 Bos taurus
100137218 Papio anubis
100358417 Oryctolagus cuniculus
380592 Xenopus laevis
29726 Rattus norvegicus
608146 Canis lupus familiaris
100072871 Equus caballus
100520422 Sus scrofa
844274 Arabidopsis thaliana
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