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Slc24a4 encodes a member of the potassium-dependent sodium/calcium exchanger protein family. De plus, nous expédions Solute Carrier Family 24 (Sodium/potassium/calcium Exchanger), Member 4 Anticorps (27) et et beaucoup plus de produits pour cette protéine.
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no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE) epsilon4 carriers nor non-carriers after adjusting for age and gender
pigment cells express robust, functional NCKX4 activity
mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients.
The expressions of NCX1 and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels.
enamel maturation is dependent upon STIM1 and SLC24A4 function, and that there are important differences in the Ca(2+) transcellular transport systems used by secretory- and maturation-stage ameloblasts.
Brain DNA methylation in sLC24A4 was associated with pathological Alzheimer disease.
These findings support a key role for SLC24A4 in calcium transport during enamel formation.
Taken together, these data demonstrate a potentially important role for NCX1 in control of Ca2+ homeostasis and link store depletion via STIM1 directly with NCX activation.
identification and sequencing, as well as mapping to chromosomal region 14q32
IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation.
Thus, despite its relative abundance in the lens, Nckx4 does not appear to have an indispensable role in the maintenance of lens clarity.
The authors show that NCKX4 shapes the cone photoresponse together with the cone-specific NCKX2: NCKX4 acts early to limit response amplitude, while NCKX2 acts late to further accelerate response recovery. The regulation of Ca(2+) by NCKX4 in cones is a novel mechanism that supports their ability to function as daytime photoreceptors and promotes their survival.
immunostaining of the apical plasma membranes of fluorotic ameloblasts was strongly reduced or absent suggesting that trafficking of NCKX4 to the apical membrane was strongly reduced
olfactory sensory neurons in NCKX4(-/-);CNGB1(DeltaCaM) mice displayed markedly reduced electro-olfactogram amplitude accompanied by alterations in other response attributes
These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2+) signaling in the MC4R pathway that leads to satiety, and a novel non-redundant role for NCKX4-mediated Ca(2+) extrusion in controlling MC4R signaling
NCKX4 activity is stimulated by ATP through activation of the P2Y receptor signalling pathway.
NCKX4 might be an important regulator of Ca(2+) transport during amelogenesis.
These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception.
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
, solute carrier family 24 member 4-like
, Na(+)/K(+)/Ca(2+)-exchange protein 4
, sodium/potassium/calcium exchanger 4
, K-dependent Na/Ca exchanger NCKX4