Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 Protéines (SLC25A19)

SLC25A19 encodes a mitochondrial protein that is a member of the solute carrier family. De plus, nous expédions Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 Anticorps (30) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat SLC25A19 SLC25A19 303676  
SLC25A19 67283 Q9DAM5
SLC25A19 60386 Q9HC21
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 Protéines sur anticorps-enligne.fr

Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Escherichia coli (E. coli) Souris His tag 100 μg Connectez-vous pour afficher 13 to 16 Days
$400.00
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
Détails

SLC25A19 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,
,
Human ,
,

Plus protéines pour Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 (SLC25A19) partenaires d'interaction

Mouse (Murine) Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 (SLC25A19) interaction partners

  1. Chronic alcohol exposure negatively impacts pancreatic mitochondrial thiamin pyrophosphate transport, and this effect is exerted, at least in part, at the level of Slc25a19 transcription and appears to involve an epigenetic mechanism.

  2. mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively

  3. We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate.[review]

Human Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 (SLC25A19) interaction partners

  1. Pancreatic acinar cells Mitochondrial Thiamin Pyrophosphate uptake process is adaptively regulated by the prevailing thiamin level and this regulation is exerted at the level of transcription of the SLC25A19 gene and involves transcription factor binding affinity/epigenetic mechanisms.

  2. Among 6 residues predicted by the docking model ( Thr (Montrer TRH Protéines)(29), Arg(30), Ile(33), Ser (Montrer SIGLEC1 Protéines)(34), Asp (Montrer ASIP Protéines)(37) and Phe(298)), only Ile(33), Ser (Montrer SIGLEC1 Protéines)(34) and Asp (Montrer ASIP Protéines)(37) were critical for function. Ser (Montrer SIGLEC1 Protéines)(34) did not affect translation/stability. Ile(33) and Asp (Montrer ASIP Protéines)(37) mutants decreased this parameter andwere expressed less in mitochondria. A polar residue was needed at position 34. His(137) and Lys (Montrer LYZ Protéines)(291) are needed for delivery to mitochondria.

  3. Chronic alcohol exposure negatively impacts pancreatic mitochondrial thiamin pyrophosphate transport, and this effect is exerted, at least in part, at the level of Slc25a19 transcription and appears to involve an epigenetic mechanism.

  4. These findings demonstrate that the genes involved in dictating thiamine homeostasis, such as SLC19A2, SLC25A19 and TPK-1, were significantly up-regulated in clinical tissues and breast cancer cell lines.

  5. Characterization of the SLC25A19 promoter and demonstration of an essential role for NF-Y in its basal activity.

  6. Compares and contrasts all the known human SLC25A (Montrer SLC25A25 Protéines)* genes and includes functional information.

  7. mutant protein lacks the normal transport activity, implying that failed deoxynucleotide transport across the inner mitochondrial membrane causes Amiah microcephaly (MCPHA)

  8. mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively

  9. We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate.[review]

  10. a pathogenic missense mutation in the SLC25A19 gene was identifiedin 4 patients who suffered from recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy

Profil protéine Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 (SLC25A19)

Profil protéine

This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Gene names and symbols associated with SLC25A19

  • solute carrier family 25 member 19 (Slc25a19)
  • solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 (slc25a19)
  • solute carrier family 25 member 19 (SLC25A19)
  • solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 (Slc25a19)
  • 2900089E13Rik Protéine
  • DNC Protéine
  • MCPHA Protéine
  • MUP1 Protéine
  • THMD3 Protéine
  • THMD4 Protéine
  • TPC Protéine
  • zgc:111878 Protéine

Protein level used designations for SLC25A19

mitochondrial thiamine pyrophosphate carrier , solute carrier family 25, member 19 , solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 , solute carrier family 25 member 19 , solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 , microcephaly, Amish , mitochondrial uncoupling protein 1 , mitochondrial deoxynucleotide carrier , Mitochondrial deoxynucleotide carrier

GENE ID SPECIES
303676 Rattus norvegicus
403024 Danio rerio
422123 Gallus gallus
454879 Pan troglodytes
483311 Canis lupus familiaris
548707 Xenopus (Silurana) tropicalis
706122 Macaca mulatta
100217405 Ovis aries
100302700 Sus scrofa
100582800 Nomascus leucogenys
67283 Mus musculus
60386 Homo sapiens
504418 Bos taurus
100174169 Pongo abelii
Fournisseurs de qualité sélectionnés pour Solute Carrier Family 25 (Mitochondrial Thiamine Pyrophosphate Carrier), Member 19 Protéines (SLC25A19)
Avez-vous cherché autre chose?