Solute Carrier Family 26, Member 9 Protéines (Slc26a9)

Slc26a9 is one member of a family of sulfate/anion transporter genes. De plus, nous expédions Slc26a9 Anticorps (9) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Slc26a9 115019 Q7LBE3
Slc26a9 320718 Q8BU91
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 60 to 65 Days
$10,888.92
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 60 to 65 Days
$7,639.51
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Slc26a9 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Solute Carrier Family 26, Member 9 (Slc26a9) partenaires d'interaction

Human Solute Carrier Family 26, Member 9 (Slc26a9) interaction partners

  1. Treatment response to ivacaftor, which aims to improve CFTR (Montrer CFTR Protéines)-channel opening probability in cystic fibrosis (Montrer S100A8 Protéines) patients with gating mutations, shows substantial variability in response, 28% of which can be explained by rs7512462 in SLC26A9.

  2. when SLC26A9 is coexpressed with F508del CFTR (Montrer CFTR Protéines), its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9.

  3. SLC26A9 single nucleotide polymorphisms modify prenatal exocrine pancreatic damage in cystic fibrosis (Montrer S100A8 Protéines)

  4. We have identified two SLC26A9 mutations decreasing Cl- channel transport in patients with a CF-like lung disease.

  5. SLC26A9 is an epithelial chloride/bicarbonate channel that can interact with the CF transmembrane regulator (CFTR (Montrer CFTR Protéines)), the protein mutated in CF

  6. Several SNPs in the 3' UTR of SLC26A9 (rs12031234, rs2282429, rs2282430)were associ (Montrer IL13 Protéines)ated with asthma in children with asthma.

  7. SLC26A9 polymorphisms lead to several function modifications (increased activity, decreased activity, altered protein expression), which could lead to a spectrum of pathophysiologies.

  8. Single nucleotide polymorphism in SLC26A9 gene is associated with cystic fibrosis (Montrer S100A8 Protéines).

  9. Report functional interaction between CFTR (Montrer CFTR Protéines) and SLC26A9 in polarized airway epithelial cells and in non-polarized HEK293 cells.

  10. the L683P mutation of SLC26A9 was found to reduce Cl(-) transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR (Montrer CFTR Protéines) ion transport activity

Mouse (Murine) Solute Carrier Family 26, Member 9 (Slc26a9) interaction partners

  1. The chloride channel (Montrer CLCA1 Protéines)/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.

  2. SLC26A9 is activated in airway inflammation. Slc26a9-deficient mice exhibited IL-13 (Montrer IL13 Protéines)-induced airway mucus obstruction. SLC26A9-mediated Cl- secretion is essential for preventing airway obstruction in allergic airway disease.

  3. Cellular HCO(3)(-) secretion, likely through SLC26A9, is the dominant mechanism whereby gastric mucosal surface pH transiently increases in response to photodamage.

  4. Slc26a9 functions as an electrogenic nCl (Montrer NCL Protéines)-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport.

  5. Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells.

  6. Slc26a9 has three discrete physiological modes: nCl (Montrer NCL Protéines)(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion cotransporter.

Profil protéine Slc26a9

Profil protéine

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.

Gene names and symbols associated with Slc26a9

  • solute carrier family 26 member 9 (SLC26A9)
  • solute carrier family 26, member 9 (Slc26a9)
  • E030002L01Rik Protéine

Protein level used designations for Slc26a9

anion transporter/exchanger protein 9 , anion transporter/exchanger-9 , solute carrier family 26 member 9 , solute carrier family 26, member 9 , SLC26A9 anion transporter/exchanger

GENE ID SPECIES
115019 Homo sapiens
320718 Mus musculus
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