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Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. De plus, nous expédions SLC38A1 Kits (7) et SLC38A1 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Mammalian Monoclonal SLC38A1 Primary Antibody pour ISt, IHC - ABIN1304968
Brown, Mathews: Activity- and age-dependent modulation of GABAergic neurotransmission by system A-mediated glutamine uptake. dans Journal of neurochemistry 2010
SNAT1 mediated L-citrulline transport modulates eNOS coupling and thus regulates nitric oxide production in hypoxic pulmonary arterial endothelial cells from newborn piglets.
Prolonged hypoxia increased SNAT1 expression in pulmonary artery endothelial cells, enhancing the ability to transport l-citrulline.
High SNAT1 expression is associated with increased cell migration in breast neoplasms.
this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis.
Results found that SLC38A1 was up-regulated in colorectal cancer cells (CRC) and significantly associated with tumor invasion and advanced disease stage. Its overexpression enhanced growth and migration of HCT116 cells providing evidence that activation of SLC38A1 may play a critical role in CRC development and progression.
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport.
The SLC38A1 protein was very low or undetectable in healthy gastric mucosa but strong staining of SLC38A1 protein was found in the cytoplasm in more than half of gastric cancer samples. SLC38A1 knockdown decreased tumor cell proliferation and migration.
SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis.
The cross-talk between Akt signaling and SNAT1 might play a critical role in the development and progression of breast cancer
Increased expression of ATA1 is frequent in human hilar cholangiocarcinoma and significantly correlated with the progression of cholangiocarcinoma, suggesting the importance of ATA1 in cancer development and progression.
The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders.
results suggest that slc38a1 may play a role in the mechanisms underlying the determination of cellular viability in astrocytes through modulation of intracellular ROS generation
SNAT1 is a key contributor to system A activity at term.
Theses data demonstrate the physiological importance of ATA1 in hepatocarcinogenesis.
Report SNAT1 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment.
A possible association between low expression of SNAT1 and suicidal behavior is suggested.
The amino acid transporter gene Slc38a1 appears to be a novel gene responsive to hypoxic stress in a manner dependent on HIF-1alpha in brown adipocytes. In addition to in vitro studies, we showed that the Slc38a1 expression was enhanced in the brown adipose tissue of obesity model mice in vivo.
Hence, pro-degenerative MAPK signaling functions upstream of SARM1 by limiting the levels of the essential axonal survival factor NMNAT2 to promote injury-dependent SARM1 activation.
Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells
We found that MeCP2 acts as a microglia-specific transcriptional repressor of
GlnT would promote both proliferation and neuronal differentiation through a mechanism relevant to the upregulation of particular proneural genes in undifferentiated P19 cells.
Inner hair cells express glutamine transporter SLC38A1.
In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature.
Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001
sodium-coupled neutral amino acid transporter 1
, solute carrier family 38, member 1
, N-system amino acid transporter 2
, amino acid transporter A1
, amino acid transporter system A1
, system A amino acid transporter 1
, system N amino acid transporter 1
, glutamine transporter
, system A transporter 2