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SLC45A2 encodes a transporter protein that mediates melanin synthesis.
Showing 10 out of 22 products:
Human Monoclonal SLC45A2 Primary Antibody pour ELISA, WB - ABIN565543
Bin, Bhin, Yang, Shin, Nam, Choi, Shin, Lee, Hwang, Cho, Lee: Membrane-Associated Transporter Protein (MATP) Regulates Melanosomal pH and Influences Tyrosinase Activity. dans PLoS ONE 2015
To gain understanding of the role of Slc45a2 and its possible interactions with other proteins involved in melanization, the role of the V-ATPase (Montrer ATP6V1H Anticorps) as a melanosomal acidifier, was analyzed.
Zebrafish albino fish are mutant in slc45a2; wild-type slc45a2 mRNA rescued the albino mutant phenotype.
Study confirmed a significant role for IRF4 (Montrer IRF4 Anticorps) rs12203592 and SLC45A2 rs16891982 in the risk of cutaneous squamous cell carcinoma development in organ transplant recipients.
our study demonstrates the feasibility of using tandem MS as a means of discovering shared immunogenic tumor-associated epitopes and identifies SLC45A2 as a promising immunotherapeutic target for melanoma with high tumor selectivity and reduced potential for autoimmune toxicity
Evaluating the influence of haplotypes of 12 SNPs within SLC45A2 in the determination of eye, hair and skin pigmentation in a highly admixed population sample and comparing their frequencies with the ones found in data retrieved from the 1000 Genomes Project. Results emphasize the role played by haplotypes at SLC45A2 in the determination of pigmentation and reinforce the relevance of SNP L374F in human pigmentation.
Data indicate AIM1 (absent in melanoma 1 (Montrer AIM1 Anticorps)) as an actin binding protein (Montrer KPTN Anticorps) and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells.
Mutation in MATP gene expression is associated with Oculocutaneous albinism type IV.
All affected members showed a novel heterozygous variant, c.208T>C (p.Y70H), in the SLC45A2 gene, which supported a diagnosis of OCA4.
Our analysis revealed 10 sun-exposure-dependent gene expression quantitative trait loci (se-eQTLs), including genes involved in skin pigmentation (SLC45A2) and epidermal differentiation (RASSF9 (Montrer RASSF9 Anticorps)).
We identitified a single missense substitution in SLC45A2 in 13 families with oculocutaneous albinism.
The reduction of tyrosinase (Montrer TYR Anticorps) activity associated with the knockdown of MATP.
The results indicated that the D93N mutation causes OCA4 as a result of loss of MATP transport activity, and that the F374 allele confers significantly lower transport activity than L374.
mRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression
This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene.
solute carrier family 45, member 2
, membrane-associated transporter protein
, membrane associated transporter protein
, absent in melanoma 1
, membrane-associated transporter protein-like
, melanoma antigen AIM1
, membrane associated transporter
, protein AIM-1
, B/AIM-1-like protein
, dominant brown
, protein underwhite
, Membrane-associated transporter protein