anti-Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 (SLC5A1) Anticorps

SLC5A1 encodes a member of the sodium-dependent glucose transporter (SGLT) family. De plus, nous expédions Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 Kits (19) et Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SLC5A1 6523 P13866
SLC5A1 25552 P53790
SLC5A1 20537 Q8C3K6
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Top anti-Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 140 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB Western blot analysis of SGLT-1 expression in Jurkat cell lysate. 100 μg 2 to 3 Days
$245.00
Détails
Humain Lapin Inconjugué ELISA, IHC, WB ABIN6269518 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269518 at 1/100 staining rat liver tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$450.00
Détails
Chien Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat lung tissue labeled with Rabbit Anti-SGLT1 Polyclonal Antibody, Unconjugated (ABIN738066) 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-SGLT1 Polyclonal Antibody, Unconjugated (ABIN738066) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$329.45
Détails
Rat Chèvre Inconjugué ELISA, IHC, WB   100 μg 6 to 7 Days
$429.84
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human lung fibrose tissue, using SGLT1, antibody at 1:100 dilution. ICC/IF Image Immunofluorescence analysis of methanol-fixed A431, using SGLT1, antibody at 1:500 dilution. 100 μL 3 to 4 Days
$466.18
Détails
Rat Chèvre Inconjugué ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Détails
Humain Chèvre Inconjugué IHC, IHC (p) Small intestine, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SLC5A1 / SGLT1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. 50 μg 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué IHC, IHC (p) Anti-SLC5A1 / SGLT1 antibody  ABIN1049342 IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-SLC5A1 / SGLT1 antibody  ABIN1049342 IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts of mouse eyetissue lysate, using SLC5A1antibody. The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cell lines, using SLC5A1 antibody (ABIN5971602) at 1/500 dilution. Immunohistochemistry of paraffin-embedded rat kidney using SLC5A1 antibody (ABIN5971602) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Détails

anti-Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 Anticorps mieux référencés

  1. Human Polyclonal SLC5A1 Primary Antibody pour WB - ABIN520242 : Viñuales, Gascón, Barranquero, Osada, Rodríguez-Yoldi: Interleukin-1beta reduces galactose transport in intestinal epithelial cells in a NF-kB and protein kinase C-dependent manner. dans Veterinary immunology and immunopathology 2013 (PubMed)

  2. Dog (Canine) Polyclonal SLC5A1 Primary Antibody pour IF (p) - ABIN915071 : Reyer, Zentek, Männer, Youssef, Aumiller, Weghuber, Wimmers, Mueller: Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers. dans Journal of agricultural and food chemistry 2017 (PubMed)

  3. Human Polyclonal SLC5A1 Primary Antibody pour ELISA, WB - ABIN6266318 : Li, Wang, Dong, Hong, Zhou, Zheng, Zheng: Phlorizin Exerts Direct Protective Effects on Palmitic Acid (PA)-Induced Endothelial Dysfunction by Activating the PI3K/AKT/eNOS Signaling Pathway and Increasing the Levels of Nitric Oxide (NO). dans Medical science monitor basic research 2018 (PubMed)

  4. Human Polyclonal SLC5A1 Primary Antibody pour ICC, IF - ABIN4353208 : He, Haque, Lin, Cominelli, Yun: Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na+/H+ exchanger 3 in SAMP1/Fc mice. dans American journal of physiology. Gastrointestinal and liver physiology 2018 (PubMed)

  5. Dog (Canine) Polyclonal SLC5A1 Primary Antibody pour IF (p), IHC (p) - ABIN738066 : Chen, Ma, Huang, Zhang, Zhong, Han, Hu, Li: Efficiency of transcellular transport and efflux of flavonoids with different glycosidic units from flavonoids of Litsea coreana L. in a MDCK epithelial cell monolayer model. dans European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2014 (PubMed)

Plus d’anticorps contre Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 partenaires d’interaction

Human Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 (SLC5A1) interaction partners

  1. Functionally damaging missense variants in SGLT1 protect from diet-induced Hyperglycemia. Reduced intestinal glucose uptake may protect from long-term Cardiometabolic outcomes.

  2. Here we show that both human and murine endometrial epithelial cells express the high affinity Na(+)-coupled glucose carrier SGLT1. Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (Slc5a1 (+/+)) but not in SGLT1 deficient (Slc5a1 (-/-)) mice.

  3. Sanger sequencing for the full coding regions of SLC5A1 resulted in the identification of 4 allelic variants in a homozygous state. Two mutations are novel and 2 have been previously reported to cause Congenital Glucose-Galactose Malabsorption

  4. SGLT1, SGLT2 and GLUT2 have roles in renal glucose handling [review]

  5. Only the index variant in SLC5A1 showed a significant association with fasting glucose in the expected opposing direction. Products of genes in all 1,5-AG-associated loci have known roles in carbohydrate digestion and enteral or renal glucose transport, suggesting that genetic variants associated with 1,5-AG influence its concentration via effects on glucose metabolism and handling

  6. High glucose levels induce MMP-2 expression in Human cardiac fibroblasts , possibly by up-regulation of SGLT1.

  7. Data suggest that a fraction of sodium glucose transporter is rapidly degraded by lysosomes and never reached the plasma membrane; another fraction reaches the membrane and is subsequently degraded by lysosomes following internalization.

  8. Data suggest expression of SGLT1 is markedly increased in kidney of patients with type 2 diabetes as compared to control subjects; SGLT1 mRNA is highly and significantly correlated with fasting and postprandial plasma glucose and HbA1c. In contrast, data suggest SGLT2 and GLUT2 mRNA in kidney are down-regulated in type 2 diabetes, but not to statistically significant level. (GLUT2 = glucose transporter type 2)

  9. Data suggest that SGLT2 expression is higher in control kidney than in kidney from subjects with type 2 diabetes; SGLT1 expression in kidney tended in the same direction; SGLT2 appears to be localized to tubular brush-border membranes; unaffected renal tissues were obtained from subjects undergoing unilateral nephrectomy for renal carcinomas.

  10. Duodenal SGLT-1 expression is increased in individuals with 1-hour postload hyperglycemia or impaired glucose tolerance, as well as in subjects with T2 Diabetes mellitus, and it positively correlates with early postload glucose excursion.

  11. Homoeriodictyol affects both the glucose metabolism and the serotonin system in Caco-2 cells via a sodium glucose cotransporter 1 protein (SGLT-1)-meditated pathway.

  12. intracellular Na+ and sugar release occurs in a random, independent manner

  13. Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop

  14. Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose.

  15. JAK3 up-regulates SGLT1 activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.

  16. Results found that SGLT1 is required for FLIPL induced cell aerobic glycolysis and survival to low glucose conditions. In patients with hepatocellular carcinoma, SGLT1 expression level was positively correlated with FLIPL expression level.

  17. Although the similarity between the pf values of SGLT1 and aquaporin-1 makes a transcellular pathway plausible, it renders water pumping physiologically negligible because the passive flux would be orders of magnitude larger.

  18. Elevated SGLT activity increases Na+ influx into myocytes and causes Na+ overload in type 2 diabetes.

  19. Compound K induces SGLT1 expression and glucose uptake in differentiated intestinal Caco-2 cells.

  20. phlorizin binding domains in sodium-glucose cotransporter family

Mouse (Murine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 (SLC5A1) interaction partners

  1. One day aftertraumatic brain injury, SGLT1 mRNA in the ipsilateral cortex was increased 160% in wild-type and 40% in RS1 knockout

  2. Here we show that both human and murine endometrial epithelial cells express the high affinity Na(+)-coupled glucose carrier SGLT1. Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (Slc5a1 (+/+)) but not in SGLT1 deficient (Slc5a1 (-/-)) mice.

  3. Loss or impairment of SGLT1 results in abnormal pancreatic islet (cyto)morphology and disturbed islet function regarding the insulin or glucagon release capacity from beta- or alpha-cells, respectively.

  4. FGF-21 regulates glucose level in diabetes partially due to inhibiting glucose absorption in the SI via inactivating SGK-1 pathway.

  5. In conclusion, the activation of JNK and p38 after cerebral ischemia caused an increase in cerebral SGLT-1. The regulation of cerebral SGLT-1 expression via the MAPK pathway may be a novel therapeutic strategy for cerebral ischemia patients.

  6. results suggest that rhythmic expression of Sglt1 is regulated at the mRNA transcriptional elongation level by enhancing the binding of the BRD4-P-TEFb complex to acetylated histones at the gene upon BMAL1-CLOCK binding to Sglt1

  7. SGLT1 deficiency turns Listeria infection into a lethal disease in mice.

  8. sodium influx through cerebral SGLT-1 may exacerbate cerebral ischemia-induced neuronal damage

  9. JAK3 up-regulates SGLT1 activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response.

  10. Enhanced cerebral sodium-glucose transporter function mediated by post-ischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage.

  11. These findings support the involvement of SGLT1 in post-oral glucose and MDG conditioning.

  12. Compound K upregulates SGLT1 expression in vivo in mice.

  13. Studied leptin and CST modulation of SGLT1 expression in hyperleptinemic type 2 diabetic mice.

  14. Cardiac knockdown of SGLT1 in a murine model of PRKAG2 cardiomyopathy attenuates the disease phenotype, implicating SGLT1 in the pathogenesis. Overexpression of SGLT1 causes pathologic cardiac hypertrophy and left ventricular failure that is reversible.

  15. In conclusion, SPAK is a powerful negative regulator of SGLT1 protein abundance in the cell membrane and thus of electrogenic glucose transport.

  16. role of SGLT1 and GLUT2 in intestinal glucose transport and sensing

  17. These results suggest that cerebral SGLT is activated by post-ischemic hyperglycemia and may be involved in the exacerbation of ischemic neuronal damage.

  18. Improved glycemic control in mice lacking Sglt1 and Sglt2.

  19. Data suggest that the absence of intestinal microbiota alters expression of (i.e., up-regulates) Sglt1 and Tas1r3 in proximal small intestine, factors associated with increased consumption of nutritive sweet solutions.

  20. SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.

Horse (Equine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 (SLC5A1) interaction partners

  1. SGLT1 expression is enhanced, with time, 2-fold in the duodenum and 3.3-fold in the ileum for horses switched, gradually over a 2-month period, from low (<1.0 g/kg bwt/day) to high hCHO (6.0 g/kg bwt/day) diets of known composition.

Cow (Bovine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 (SLC5A1) interaction partners

  1. Na+-dependent glucose cotransporter(SGLT)1 mRNA was most abundant in bovine intestine, at intermediate levels in bovine kidney, and at lower levels in bovine mammary gland, liver, and lung.

Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 1 (SLC5A1) profil antigène

Profil protéine

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC5A1

  • solute carrier family 5 member 1 (SLC5A1) anticorps
  • solute carrier family 5 (sodium/glucose cotransporter), member 1 (slc5a1) anticorps
  • solute carrier family 5 member 1 (Slc5a1) anticorps
  • solute carrier family 5 (sodium/glucose cotransporter), member 1 (Slc5a1) anticorps
  • D22S675 anticorps
  • NAGT anticorps
  • Sglt1 anticorps
  • SLC5A1 anticorps
  • zgc:66074 anticorps
  • zgc:85782 anticorps

Protein level used designations for SLC5A1

Na+/glucose cotransporter 1 , high affinity sodium-glucose cotransporter , sodium/glucose cotransporter 1 , SGLT1 , solute carrier family 5 (sodium/glucose cotransporter), member 1 , Na(+)/glucose cotransporter 1 , cortical sodium-D-glucose cotransporter , solute carrier family 5 member 1 , solute carrier family 5, member 1 , sodium/glucose cotransporter 1-like , Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter) , sodium glucose cotransporter 1 , sodium-glucose cotransporter 1 , solute carrier family 5, member alpha 1 , sodium-glucose cotransporter-like 1 , Na+/glucose co-transporter , sodium/glucose cotransporter-like protein , Na+/glucose cotransporter , SGLT-1

GENE ID SPECIES
6523 Homo sapiens
393654 Danio rerio
458779 Pan troglodytes
717070 Macaca mulatta
100009262 Oryctolagus cuniculus
100137235 Papio anubis
100435495 Pongo abelii
100593847 Nomascus leucogenys
25552 Rattus norvegicus
20537 Mus musculus
492299 Canis lupus familiaris
100033952 Equus caballus
282361 Bos taurus
492300 Ovis aries
397113 Sus scrofa
395496 Gallus gallus
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