Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 Protéines (SLC6A19)

SLC6A19 encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. De plus, nous expédions SLC6A19 Anticorps (17) et SLC6A19 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SLC6A19 340024 Q695T7
SLC6A19 74338 Q9D687
Rat SLC6A19 SLC6A19 664630 Q2A865
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Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Détails
Wheat germ Humain GST tag 2 μg 11 to 12 Days
$230.67
Détails

SLC6A19 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) partenaires d'interaction

Human Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) interaction partners

  1. SIT1, B(0)AT1 and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes.

  2. PKB/Akt up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt-expressing epithelial and tumor cells.

  3. JAK2 up-regulates SLC6A19 activity which may foster amino acid uptake into JAK2 expressing cells.

  4. Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts.

  5. A novel SLC6A19 gene mutation is associated with late-onset seizures in a Korean patient with Hartnup disorder.

  6. We identified six mutations in SLC6A19 that cosegregated with disease in the predicted recessive manner, with most affected individuals being compound heterozygotes.

  7. One mutation, the D173N allele, is present in 42% of Hartnup chromosomes from apparently unrelated families from both Australia and North America.

  8. Hartnup disorder is allelically heterogeneous with two mutated SLC6A19 allele.

  9. These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension.

  10. Suggest that amino acid transporters B(0)AT1 and b(0,+)AT are involved in the reabsorption of L-citrulline in the kidney, at least in part, by mediating the apical membrane transport of L-citrulline in renal tubule cells.

  11. novel homozygous mutation of G284R in the transmembrane domain of the SLC6A19 transporter found in the proband, with typical dermatologic and neurologic manifestations and increased levels of urinary neutral amino acids

Mouse (Murine) Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) interaction partners

  1. analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin

  2. Slc6a19 expression in the intestine is regulated at three different levels involving promoter methylation, histone modification, and opposing transcription factors.

  3. the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 and the neutral amino acid transporter B0AT1

  4. Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse.

  5. Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts.

  6. Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo.

  7. We isolated the human homolog of B(0)AT1, called SLC6A19, and determined its size and molecular organization. We then identified mutations in SLC6A19 in members of the original family in whom Hartnup disorder was discovered

  8. The mechanism of the mouse (m)B0AT1 (slc6a19) transporter was studied in detail using two electrode voltage-clamp techniques and tracer studies in the Xenopus oocyte expression system.

  9. The relatively constant [Na(+)] along the renal proximal tubule both drives the uptake of neutral amino acids via B(0)AT1 thermodynamically and ensures that, upon binding, these are translocated efficiently into the cell.

  10. This study shows the luminal brush-border localization of the Na(+)-dependent amino and imino acid transporters B degrees AT1 and XT3s1/SIT1 in kidney and intestine.

  11. functional association of mutant B(0)AT1 transporters with ACE2 and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder

Profil protéine SLC6A19

Profil protéine

This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder.

Gene names and symbols associated with SLC6A19

  • solute carrier family 6 member 19 (SLC6A19)
  • solute carrier family 6 (neurotransmitter transporter), member 19 (Slc6a19)
  • solute carrier family 6 member 19 (Slc6a19)
  • solute carrier family 6 (neutral amino acid transporter), member 19 S homeolog (slc6a19.S)
  • solute carrier family 6 (neutral amino acid transporter), member 19b (slc6a19b)
  • 4632401C08Rik Protéine
  • B0at1 Protéine
  • B<0>AT1 Protéine
  • HND Protéine
  • slc6a19 Protéine
  • wu:fd58f10 Protéine
  • XROSIT Protéine
  • zgc:66050 Protéine

Protein level used designations for SLC6A19

sodium-dependent amino acid transporter system B0 , sodium-dependent neutral amino acid transporter B(0)AT1 , solute carrier family 6 (neurotransmitter transporter), member 19 , solute carrier family 6 member 19 , system B(0) neutral amino acid transporter AT1 , system B0 neutral amino acid transporter , b(0)AT1 , neutral amino acid transporter , solute carrier family 6, member 19 , system B0 neutral amino acid transporter SLC6A19 , sodium-dependent neutral amino acid transporter B(0) , solute carrier family 6 (neutral amino acid transporter), member 19 S homeolog , solute carrier family 6 (neurotransmitter transporter), member 19b

GENE ID SPECIES
340024 Homo sapiens
74338 Mus musculus
664630 Rattus norvegicus
100683912 Canis lupus familiaris
641346 Sus scrofa
100173524 Pongo abelii
447481 Xenopus laevis
326030 Danio rerio
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