Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 Protéines (SLC7A8)

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. De plus, nous expédions SLC7A8 Anticorps (36) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SLC7A8 23428 Q9UHI5
Rat SLC7A8 SLC7A8 84551 Q9WVR6
SLC7A8 50934 Q9QXW9
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Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Détails
Wheat germ Humain GST tag 2 μg 11 to 12 Days
$338.33
Détails

SLC7A8 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) partenaires d'interaction

Human Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. These preliminary data suggest that a relevant proportion of age-related hearing loss cases could be explained by SLC7A8 mutations.

  2. Data reveal that LAT2 functions as an oncogenic protein and could regulate glutamine-dependent mTOR activation to promote glycolysis and decrease GEM sensitivity in pancreatic cancer

  3. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution

  4. LAT2 genes may play important roles in leiomyoma cell proliferation and regulate leiomyoma growth

  5. LAT1 and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.

  6. LAT1 and LAT2 are present and functional in the syncytiotrophoblast MVM, whereas LAT2 is also expressed in the BM and in the fetal capillary endothelium.

  7. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.

  8. the interaction of CD98/LAT2 with ICAM-1, found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE cell monolayers

  9. identify LAT1 and LAT2 as members of system L that mediate transmembrane movement of l-CSNO

  10. Genetic variation in LAT1 and LAT2 does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.

Mouse (Murine) Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. distinct molecular LAT2-features determine bidirectional amino acid transport but only an unidirectional thyroid hormone import.

  2. Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone transporter Mct8, which is co-expressed in many cell types

  3. In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.

  4. the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates

  5. System L functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids.

  6. The positive effect of non-T cell activation linker (NTAL) on Akt phosphorylation and mast cell survival requires LAT.

  7. LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP mRNAs were not.

Profil protéine SLC7A8

Profil protéine

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).

Gene names and symbols associated with SLC7A8

  • solute carrier family 7 member 8 (SLC7A8)
  • solute carrier family 7 member 8 (Slc7a8)
  • solute carrier family 7 member 8 L homeolog (slc7a8.L)
  • solute carrier family 7 member 8 (slc7a8)
  • solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8)
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8b (slc7a8b)
  • 4F2LC-5 Protéine
  • AA408822 Protéine
  • lat2 Protéine
  • Lat4 Protéine
  • lpi-pc1 Protéine
  • si:ch211-14a17.3 Protéine
  • si:zc14a17.3 Protéine
  • slc7a8 Protéine
  • XAA2 Protéine

Protein level used designations for SLC7A8

L-type amino acid transporter 2 , integral membrane protein E16H , large neutral amino acids transporter small subunit 2 , solute carrier family 7 (amino acid transporter, L-type), member 8 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 , cationic amino acid transporter y+ system , solute carrier family 7 member 8 , glycoprotein-associated amino acid transporter LAT2 , 4F2-LC5 , mLAT2 , solute carrier family 8 (cationic amino acid transporter, y+ system), member 7 , solute carrier family 7 (amino acid transporter light chain, L system), member 8 , zmp:0000000645 , zmp:0000000781

GENE ID SPECIES
23428 Homo sapiens
84551 Rattus norvegicus
380297 Xenopus laevis
394580 Xenopus (Silurana) tropicalis
452793 Pan troglodytes
490608 Canis lupus familiaris
536818 Bos taurus
713511 Macaca mulatta
100009408 Oryctolagus cuniculus
100134829 Sus scrofa
100172820 Pongo abelii
50934 Mus musculus
100007990 Danio rerio
100052453 Equus caballus
100717482 Cavia porcellus
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