Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Protéines (SLC9A3R2)

SLC9A3R2 encodes a member of the NHERF family of PDZ scaffolding proteins. De plus, nous expédions Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Anticorps (78) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SLC9A3R2 9351 Q15599
SLC9A3R2 65962 Q9JHL1
SLC9A3R2 116501 Q920G2
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Top Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Protéines sur anticorps-enligne.fr

Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Escherichia coli (E. coli) Humain His tag,T7 tag 100 μg 15 to 18 Days
$682.00
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Levure Lapin His tag   1 mg 60 to 71 Days
$2,847.17
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Levure Rat His tag   1 mg 60 to 71 Days
$2,911.33
Détails

SLC9A3R2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human
,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) partenaires d'interaction

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins.

  2. Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin is unaffected by S303D

  3. Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCdelta signaling.

  4. Data indicate that the tails promote different microvillar localizations for EBP50 and E3KARP, which localized along the full length and to the base of microvilli, respectively.

  5. Crystal structure of NHERF2 PDZ1 domain complex with C-terminal LPA2 sequence. The PDZ1-LPA2 binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions.

  6. NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3

  7. functional regulation of C3aR by NHERFs in human mast cells

  8. AnxA2 and NHERF2 form a scaffold complex that links adjacent Tir molecules at the plasma membrane forming a lattice that could be involved in retention and dissemination of other effectors at the bacterial attachment site.

  9. NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling.

  10. CaMKII inhibition of NHE3 reguires NHEF2.

  11. Data show that both NHERF2 and NHERF1 are involved in setting NHE3 activity.

  12. MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.

  13. The results of this study revealed that NHERF-2 can interact with GLAST in astrocytes to enhance GLAST stability and activity.

  14. WNK4 and NHERF2 synergistically regulate TRPV5 by enhancing its forward trafficking and increasing its stability at plasma membrane, respectively.

  15. The authors generated a HeLa cell line stably expressing HA-tagged NHERF2 and found that Map, EspI and NleH1 colocalize and interact with intracellular NHERF2 via their C-terminal PDZ-binding motif.

  16. Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells.

  17. NHERF1 and NHERF2 exhibit isotype-specific effects on G protein activation.

  18. Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranes

  19. E3KARP has a restricted tissue distribution with the highest expression being found in lung. It is largely colocalized with moesin and radixin, especially in the alveoli of the lung, as well as being highly enriched in the renal corpuscle.

  20. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling.

Cow (Bovine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. the essential role of NHERF2 in endothelial cell adhesion/migration and angiogenesis. [NHERF2]

Pig (Porcine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. Analysis showed that SLC9A3R2 gene has the closest genetic relationship with the SLC9A3R2 gene of human; it is structured in 7 exons and 6 introns; tissue expression analysis indicated that SLC9A3R2 gene is differentially expressed in different tissues.

Mouse (Murine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) interaction partners

  1. NHERF2 and NHERF3 have overlapping roles in NHE3 stimulation by LPA and inhibition by elevated Ca(2+) and cGMP.

  2. LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia.

  3. Knockdown of NHERF2 decreased colon cancer progression. NHERF2 deletion attenuated Stat3 activation and CD24 expression in colon cancer cells.

  4. NHERF2 is differentially distributed to lipid rafts in brush border membrane fractions of NHE3.

  5. involvement of NHERF2 in multiple apical regulatory processes and interactions with luminal contents

  6. NHERF2 is necessary for multiple aspects of acute regulation of NHE3 in intact mouse small intestine

  7. It was concluded that NHERF2 plays important roles in tethering NHE3 to a position near the terminal web and in second messenger inhibition of NHE3 in a signal- and segment-specific fashion.

  8. Lysophosphatidic acid (LPA) is a potent stimulant of NHE3 and fluid absorption in the intestine, signaling through LPA(5). Regulation by LPA(5) depends on its interaction with NHERF2.

  9. demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3

  10. the function of SIP-1/NHERF2 as an SRY cofactor during testis determination is conserved between human and mouse

  11. analysis of NHERF recognition by ERM proteins

  12. NHERF-2 and mGluR5 exhibit overlapping patterns of expression in mouse brain, where their association prolongs intracellular calcium mobilization by mGluR5 and promotes mGluR5-mediated toxicity.

  13. NHERF-1 but not NHERF-2 in native intestinal epithelium is involved in the formation of CFTR-containing functional complexes that serve to position CFTR in the crypt apical membrane and to optimize its function as a cAMP- and cGMP-regulated anion channel

  14. There were no differences in the urinary excretion of protein or low-molecular-weight proteins between wild-type control, NHERF-1 and NHERF-2 deficient mice.

  15. Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show that NHERF1 is essential for both normal and mutant CFTR function [review]

  16. CFTR-dependent duodenal bicarbonate-ion secretion in mouse models of NHERF-2 loss of function.

Profil protéine Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2)

Profil protéine

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with SLC9A3R2

  • SLC9A3 regulator 2 (SLC9A3R2)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (SLC9A3R2)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (Slc9a3r2)
  • SLC9A3 regulator 2 (Slc9a3r2)
  • SLC9A3 regulator 2 S homeolog (slc9a3r2.S)
  • 0610011L07Rik Protéine
  • 1200011K07Rik Protéine
  • 2010007A20Rik Protéine
  • E3karp Protéine
  • NHE3RF2 Protéine
  • nherf-2 Protéine
  • nherf2 Protéine
  • Octs2 Protéine
  • Sip-1 Protéine
  • Sip1 Protéine
  • slc9a3r2 Protéine
  • Sryip1 Protéine
  • Tka-1 Protéine

Protein level used designations for SLC9A3R2

NHE3 kinase A regulatory protein E3KARP , NHE3 regulatory factor 2 , Na(+)/H(+) exchange regulatory cofactor NHE-RF2 , SRY-interacting protein 1 , sodium/hydrogen exchanger 3 kinase A regulatory protein , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 , solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 , solute carrier family 9 isoform A3 regulatory factor 2 , tyrosine kinase activator protein 1 , solute carrier family 9 isoform 3 regulator 2 , PDZ domain containing protein NHERF-2 , PDZ domain-containing protein NHERF-2 , sodium-hydrogen exchanger regulatory factor 2 , Sry interacting protein 1 , sodium/hydrogen exchanger , solute carrier family 9 isoform 3 regulator 2, isoform A; sodium/hydrogen exchanger , NHERF-2 , SIP-1 , TKA-1 , NHE3 kinase A regulatory protein 2 , SLC9A3 regulator 2 S homeolog , solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 S homeolog

GENE ID SPECIES
9351 Homo sapiens
416550 Gallus gallus
479884 Canis lupus familiaris
694658 Macaca mulatta
768005 Bos taurus
100008813 Oryctolagus cuniculus
100192448 Sus scrofa
65962 Mus musculus
116501 Rattus norvegicus
100731241 Cavia porcellus
399076 Xenopus laevis
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