Solute Carrier Organic Anion Transporter Family, Member 1C1 Protéines (SLCO1C1)

SLCO1C1 encodes a member of the organic anion transporter family. De plus, nous expédions SLCO1C1 Anticorps (19) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SLCO1C1 53919 Q9NYB5
SLCO1C1 58807 Q9ERB5
Rat SLCO1C1 SLCO1C1 84511 Q9EPZ7
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
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SLCO1C1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human
,
Mouse (Murine)
,

Plus protéines pour Solute Carrier Organic Anion Transporter Family, Member 1C1 (SLCO1C1) partenaires d'interaction

Human Solute Carrier Organic Anion Transporter Family, Member 1C1 (SLCO1C1) interaction partners

  1. The genetic variant, rs3794271, located within the PDE3A (Montrer PDE3A Protéines)-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF (Montrer TNF Protéines) response in a large UK rheumatoid arthritis cohort.

  2. We found a highly significant association between PDE3A (Montrer PDE3A Protéines)-SLCO1C1 and the clinical response to TNF (Montrer TNF Protéines) blockers

  3. The PDE3A (Montrer PDE3A Protéines)-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF (Montrer TNF Protéines) treatment response.

  4. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 (Montrer SLCO3A1 Protéines) variant 2, OATP4A1, LAT2 (Montrer LAT2 Protéines) and CD98 (Montrer SLC3A2 Protéines) were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8 (Montrer MCT8 Protéines), MCT10, OATP3A1 (Montrer SLCO3A1 Protéines) variant 1 and LAT1 (Montrer LAT Protéines) were similar.

  5. The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis.

  6. We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis.

  7. OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy.

  8. OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation

  9. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.

Mouse (Murine) Solute Carrier Organic Anion Transporter Family, Member 1C1 (SLCO1C1) interaction partners

  1. This study identified the thyroid hormone (Montrer PTH Protéines) transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex

  2. The data demonstrate that OATP1c1 and MCT8 (Montrer MCT8 Protéines) expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.

  3. Transporters MCT8 (Montrer MCT8 Protéines) and OATP1C1 maintain murine brain thyroid hormone (Montrer PTH Protéines) homeostasis.

  4. SLCO1C1 is expressed in the neuronal cell lineage during brain development. Expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia.

  5. expression of candidate thyroid hormone (Montrer PTH Protéines) transporters Lat1 (Montrer SLC7A5 Protéines), Mct8 (Montrer MCT8 Protéines), Mct10, and Oatp1c1 in mouse cochlear development

  6. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.

Profil protéine SLCO1C1

Profil protéine

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SLCO1C1

  • solute carrier organic anion transporter family member 1C1 (SLCO1C1)
  • solute carrier organic anion transporter family, member 1c1 (Slco1c1)
  • Bsat1 Protéine
  • OATP-14 Protéine
  • OATP-F Protéine
  • OATP1 Protéine
  • OATP1C1 Protéine
  • Oatp2 Protéine
  • Oatp14 Protéine
  • Oatpf Protéine
  • OATPRP5 Protéine
  • Slc21a14 Protéine

Protein level used designations for SLCO1C1

OAT-RP-5 , OATP-14 , organic anion transporter F , organic anion transporter polypeptide-related protein 5 , organic anion transporting polypeptide 14 , organic anion-transporting polypeptide 14 , solute carrier family 21 (organic anion transporter), member 14 , solute carrier family 21 member 14 , solute carrier organic anion transporter family member 1C1 , thyroxine transporter , organic anion transporter 2 , BBB-specific anion transporter type 1 , blood-brain barrier specific anion transporter , blood-brain barrier-specific anion transporter 1

GENE ID SPECIES
53919 Homo sapiens
609603 Canis lupus familiaris
518047 Bos taurus
100144344 Oryctolagus cuniculus
58807 Mus musculus
84511 Rattus norvegicus
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