anti-Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1) Anticorps

SORCS1 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. De plus, nous expédions SORCS1 Kits (8) et SORCS1 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SORCS1 114815 Q8WY21
SORCS1 309533  
SORCS1 58178  
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Top anti-SORCS1 Anticorps sur

Showing 10 out of 41 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué FACS, WB Western blot analysis of SORCS1 Antibody in K562 cell line lysates (35ug/lane) Flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL 2 to 3 Days
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with SORCS1 polyclonal antibody  at 1:250-1:500 dilution. Immunohistochemical staining of human colon with SORCS1 polyclonal antibody  shows strong cytoplasmic and membranous positivity in glandular cells at 1:50-1:200 dilution. 100 μL 11 to 12 Days
Humain Lapin FITC FACS, ELISA, WB   200 μL 11 to 14 Days
Humain Lapin HRP FACS, ELISA, WB   200 μL 11 to 14 Days
Humain Lapin Alkaline Phosphatase (AP) FACS, ELISA, WB   200 μL 11 to 14 Days
Humain Lapin PE FACS, ELISA, WB   200 μL 11 to 14 Days
Humain Lapin Biotin FACS, ELISA, WB   200 μL 11 to 14 Days
Humain Lapin Inconjugué FACS, WB   400 μL 11 to 14 Days
Humain Lapin APC FACS, ELISA, WB   200 μL 11 to 14 Days
Humain Lapin PE FACS, ELISA, WB   200 μL 16 Days

anti-SORCS1 Anticorps mieux référencés

  1. Human Polyclonal SORCS1 Primary Antibody pour ICC, IF - ABIN4355172 : Subkhangulova, Malik, Hermey, Popp, Dittmar, Rathjen, Poy, Stumpf, Beed, Schmitz, Breiderhoff, Willnow: SORCS1 and SORCS3 control energy balance and orexigenic peptide production. dans EMBO reports 2019 (PubMed)

Plus d’anticorps contre SORCS1 partenaires d’interaction

Human Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1) interaction partners

  1. Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations.

  2. We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with polycystic ovary syndrome. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels and increased glucose stimulated insulin secretion

  3. Data identified associations between single nucleotide polymorphisms in SORCS1 and renal function in large cohorts of European and African ancestry.

  4. The propeptide region of sorCS1 contains two separate sites for binding to sortilin. One of these sites is removed from human sorCS1 during processing.

  5. Genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 is associated with late onset Alzheimer disease in the Chinese Han population.

  6. The genetic link between AD[Alzheimer's disease]and SORCS1 gene variations are influenced by ethnic background, sex and whether an individual has type 2 diabetes mellitus

  7. [review] Emerging data from a rapidly growing area of research implicates the Vps10 family of receptors and the retromer in physiological intracellular trafficking by neurotrophins and pathogenesis of neurodegeneration.

  8. Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population

  9. suggest that genetic variation in SORCS1 is associated with memory performance

  10. the 4 recently reported SNPs,located near BNC2, SORCS1, GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 SNP, findings do not rule out possible relationship with HbA1c

  11. Dysfunction of SorCS1 may contribute to both the amyloid precursor protein/amyloidbeta disturbance underlying Alzheimer disease and the insulin/glucose disturbance underlying diabetes mellitus.

  12. SNP which is nearest to SORCS1 is highly significantly associated with glycemic control in individuals with type 1 diabetes

  13. human sorCS1 has three isoforms, sorCS1a-c, with completely different cytoplasmic tails and differential expression in tissues

  14. Different motifs regulate trafficking of SorCS1 isoforms.

  15. SORCS1 SNPs show genotypic association with Alzheimer disease.

Mouse (Murine) Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1) interaction partners

  1. our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.

  2. Male mice with either the APP/PSEN1 or Sorcs1 -/- genotype displayed earlier onset and persistent impairment in both glucose homeostasis and in learning behavior.

  3. SorCS1 and APP share trafficking pathways and that SorCS1c can retain APP from insertion into anterograde transport vesicles

  4. SorCs1 is a global protein trafficking regulator, including AMPA receptors and neurexins.

  5. SORCS1 is sufficient to promote secretory granule biogenesis in metabolically stressed beta cells

  6. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis

  7. identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus

  8. Different motifs regulate trafficking of Sorcs isoforms.

SORCS1 profil antigène

Profil protéine

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain\; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins\; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SORCS1

  • sortilin related VPS10 domain containing receptor 1 (SORCS1) anticorps
  • sortilin-related VPS10 domain containing receptor 1 (Sorcs1) anticorps
  • hSorCS anticorps
  • mSorCS anticorps
  • Sorcs anticorps

Protein level used designations for SORCS1

VPS10 domain receptor protein SORCS 1 , VPS10 domain-containing receptor SorCS1

114815 Homo sapiens
477816 Canis lupus familiaris
100155686 Sus scrofa
537536 Bos taurus
309533 Rattus norvegicus
58178 Mus musculus
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