Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1) Kits ELISA

SORCS1 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. De plus, nous expédions SORCS1 Anticorps (41) et SORCS1 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SORCS1 114815 Q8WY21
Anti-Rat SORCS1 SORCS1 309533  
SORCS1 58178  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 5.86 pg/mL 23.5-1500 pg/mL Typical standard curve 96 Tests 15 to 18 Days
Souris 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests 15 to 18 Days
  96 Tests 26 to 36 Days

Plus Kits ELISA pour SORCS1 partenaires d'interaction

Human Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1) interaction partners

  1. Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations.

  2. We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with polycystic ovary syndrome. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels and increased glucose stimulated insulin secretion

  3. Data identified associations between single nucleotide polymorphisms in SORCS1 and renal function in large cohorts of European and African ancestry.

  4. The propeptide region of sorCS1 contains two separate sites for binding to sortilin. One of these sites is removed from human sorCS1 during processing.

  5. Genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 is associated with late onset Alzheimer disease in the Chinese Han population.

  6. The genetic link between AD[Alzheimer's disease]and SORCS1 gene variations are influenced by ethnic background, sex and whether an individual has type 2 diabetes mellitus

  7. [review] Emerging data from a rapidly growing area of research implicates the Vps10 family of receptors and the retromer in physiological intracellular trafficking by neurotrophins and pathogenesis of neurodegeneration.

  8. Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population

  9. suggest that genetic variation in SORCS1 is associated with memory performance

  10. the 4 recently reported SNPs,located near BNC2, SORCS1, GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 SNP, findings do not rule out possible relationship with HbA1c

  11. Dysfunction of SorCS1 may contribute to both the amyloid precursor protein/amyloidbeta disturbance underlying Alzheimer disease and the insulin/glucose disturbance underlying diabetes mellitus.

  12. SNP which is nearest to SORCS1 is highly significantly associated with glycemic control in individuals with type 1 diabetes

  13. human sorCS1 has three isoforms, sorCS1a-c, with completely different cytoplasmic tails and differential expression in tissues

  14. Different motifs regulate trafficking of SorCS1 isoforms.

  15. SORCS1 SNPs show genotypic association with Alzheimer disease.

Mouse (Murine) Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1) interaction partners

  1. our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.

  2. Male mice with either the APP/PSEN1 or Sorcs1 -/- genotype displayed earlier onset and persistent impairment in both glucose homeostasis and in learning behavior.

  3. SorCS1 and APP share trafficking pathways and that SorCS1c can retain APP from insertion into anterograde transport vesicles

  4. SorCs1 is a global protein trafficking regulator, including AMPA receptors and neurexins.

  5. SORCS1 is sufficient to promote secretory granule biogenesis in metabolically stressed beta cells

  6. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis

  7. identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus

  8. Different motifs regulate trafficking of Sorcs isoforms.

SORCS1 profil antigène

Antigen Summary

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain\; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins\; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with SORCS1

  • sortilin related VPS10 domain containing receptor 1 (SORCS1) anticorps
  • sortilin-related VPS10 domain containing receptor 1 (Sorcs1) anticorps
  • hSorCS anticorps
  • mSorCS anticorps
  • Sorcs anticorps

Protein level used designations for SORCS1

VPS10 domain receptor protein SORCS 1 , VPS10 domain-containing receptor SorCS1

114815 Homo sapiens
477816 Canis lupus familiaris
100155686 Sus scrofa
537536 Bos taurus
309533 Rattus norvegicus
58178 Mus musculus
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