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SORCS3 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. De plus, nous expédions SORCS3 Anticorps (23) et SORCS3 Protéines (5) et beaucoup plus de produits pour cette protéine.
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First study reporting on human subjects with a SORCS3 gene defect with infantile spasms and intellectual disability; this supports the important role of SORCS3 in the central nervous system.
SORCS3 may be important in MS pathogenesis.
Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations.
The propeptide is not a requirement for normal processing of the receptor and does not prevent ligands from binding to the SorCS3 precursor form
our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.
SorCS3 serves as a key regulator of synaptic transmission and plasticity. Results show that glutamate receptor functions are controlled by SorCS3 to secure correct functioning of excitatory synapses. The receptor plays a more central role in CA1 compared to the dentate gyrus, correlating well with the expression pattern. Reduced function of SorCS3 results in impaired synaptic mechanisms in the hippocampus.
Study demonstrates that SorCS3 expression is restricted to the developing and adult nervous system
Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain\; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins\; it is not yet known if this encoded protein is also a preproprotein.
sortilin-related VPS10 domain containing receptor 3
, VPS10 domain receptor protein SORCS 3
, VPS10 domain-containing receptor SorCS3-like
, VPS10 domain-containing receptor SorCS3
, VPS10 domain receptor protein SORCS 3 (SORCS3)