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SNX26 encodes a member of the sorting nexin family.
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Human Polyclonal SNX26 Primary Antibody pour ELISA, IHC - ABIN4355005
Teasdale, Loci, Houghton, Karlsson, Gleeson: A large family of endosome-localized proteins related to sorting nexin 1. dans The Biochemical journal 2001
Human Polyclonal SNX26 Primary Antibody pour IHC (p), IHC - ABIN251667
Liu, Nakazawa, Tezuka, Yamamoto: Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. dans The Journal of biological chemistry 2006
ARHGAP33 is associated with b (Montrer SORT1 Anticorps)rain phenotypes of patients wit (Montrer NTRK2 Anticorps)h schizophrenia.
TCGAP interacts with Fyn (Montrer FYN Anticorps) and is phosphorylated by Fyn (Montrer FYN Anticorps), with tyrosine-406 in the GTPase-activating protein (GAP) domain as a major Fyn (Montrer FYN Anticorps)-mediated phosphorylation site.
Results show that neurite outgrowth multiadaptor RhoGAP protein, NOMA-GAP, plays an essential role downstream of NGF (Montrer NGFB Anticorps) in promoting neurite outgrowth and extension by recruiting SHP2 (Montrer PTPN11 Anticorps) and activating Cdc42 (Montrer CDC42 Anticorps).
ARHGAP33 interacts with SORT1 (Montrer SORT1 Anticorps) to cooperatively regulate TrkB (Montrer NTRK2 Anticorps) trafficking. ARHGAP33 KO mice exhibit reduced expression of synaptic TrkB (Montrer NTRK2 Anticorps), impaired dendritic spine development and neuropsychiatric disorder-related behavioural abnormalities.
Results indicate that SNX26 interacts with PSD-95 (Montrer DLG4 Anticorps) and regulates formation of dendritic spines.
Cofilin (Montrer CFL1 Anticorps) activation during late cortical development depended on NOMA-GAP expression and subsequent inhibition of Cdc42 (Montrer CDC42 Anticorps). In utero expression of active cofilin (Montrer CFL1 Anticorps) was sufficient to restore postnatal dendritic complexity in NOMA-GAP-deficient animals.
Overexpression of the full-length and C-terminal fragments of TCGAP inhibits insulin (Montrer INS Anticorps)-stimulated glucose uptake and GLUT4 (Montrer SLC2A4 Anticorps) translocation.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene.
neurite outgrowth multiadaptor RhoGAP protein
, rho GTPase-activating protein 33
, rho-type GTPase-activating protein 33
, sorting nexin 26
, sorting nexin-26
, tc10/CDC42 GTPase-activating protein
, TC10/CDC42 GTPase-activating protein