Sphingomyelin Synthase 2 (SGMS2) Kits ELISA

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. De plus, nous expédions Sphingomyelin Synthase 2 Anticorps (60) et Sphingomyelin Synthase 2 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SGMS2 166929 Q8NHU3
SGMS2 74442 Q9D4B1
SGMS2 310849 Q4JM44
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Plus Kits ELISA pour Sphingomyelin Synthase 2 partenaires d'interaction

Human Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. our results demonstrate that SMS2 can activate the Wnt/beta-catenin pathway and promote intracellular cholesterol accumulation, both of which can contribute to the induction of ER stress and finally lead to ED.

  2. SMS regulates the expression and function of drug transporters P-gp and MRP2.

  3. findings suggest that the C-terminal tails of SMSs are involved in homodimer formation, which is required for efficient transport from the ER.

  4. PPARdelta activation may be a potential risk of atherosclerosis through enhancing activity of SMS2

  5. F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms-deficient cells.

  6. SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion

  7. Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 and SMS2.

  8. direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2

  9. Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.

  10. Data show that sphingomyelin synthases SMS1 and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively.

  11. Results indicate that both synthase (SMS)1 and 2 contribute to sphingomyelin (SM) de novo synthesis and control SM levels in the cells and on the cell membrane including plasma membrane.

  12. SMS2 is a key factor in control of sphingomyelin and diacylglycerol metabolism within the cell, and thus it influences apoptosis.

  13. SMS2 regulates subcellular pools of diacylglycerol-binding proteins in the Golgi apparatus.

  14. SMS2 (Sphingomyelin synthase 2) physiologically contributes to de novo Sphingomyelin biosynthesis and plasma membrane Sphingomyelin levels

  15. Both SMS1 and SMS2 contain two histidines and one aspartic acid which are conserved within the lipid phosphate phosphatase superfamily. Site-directed mutagenesis of these amino acids abolished SMS activity without altering cellular distribution.

  16. These results suggested that posttranslational palmitoylation is important for determination of the subcellular localization of SMS2.

  17. Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.

Mouse (Murine) Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. SMS2 generates sphingomyelin in the epidermis and contributes to epidermal permeability barrier function

  2. 2-Hydroxy-oleic acid inhibited rather than activated recombinant SMS1 (rSMS1) and rSMS2 in a dose-dependent fashion.

  3. This study showed that MWM learning was deteriorated and associated with depression-like tendency in SMS2 KO mice.

  4. These results demonstrate that SMS2 deficiency inhibits DSS-induced colitis and subsequent colitis-associated colon cancer via inhibition of colon epithelial cell-mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer.

  5. It was suggested that very long chain SM but not long chain SM were decreased in SMS2-deficient mice liver and plasma. And the exogenously added very long chain SM (d18:1/24:0) could activate macrophages directly, suggesting a novel role of plasma very long chain SM in modulating macrophage activation and resulting inflammation.

  6. These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14.

  7. Study provides a mouse model for fetal alcohol spectrum disorder. Due to the accumulation of ceramide in vivo, SMS2 knockout mice allows to investigate how ceramide regulates alcohol-induced neural apoptosis.

  8. study provided evidence that genetic inhibition of SMS2 elevated glucose clearance through activation of glucose uptake into insulin-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2

  9. Thus, imaging mass spectrometry can provide visual assessment of the contribution of SMS2 on acyl-chain- and region-specific sphingomyelin metabolism in the kidneys

  10. characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice

  11. study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity

  12. Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma suppression.

  13. Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2)+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE-/- and Ldlr-/- mice.

  14. SMS2 deficiency decreases atherosclerosis and inhibits inflammation in mice.

  15. Defects in the stria vascularis with reductions in endocochlear potentials together with hair cell dysfunction may account, at least partially, for hearing impairments in SMS1-/- mice.

  16. SMS2 over-expression was probably associated with increased expression of aortic inflammatory biomarkers, as well as decreased numbers of CD34/KDR-positive cells, CACs and CFUs in circulation

  17. Ablation of CerS2 causes changes in intrinsic membrane curvature, leading to strong morphological alterations that promote vesicle adhesion, membrane fusion, and tubule formation.

  18. SMS1 and SMS2 play distinct roles in regulating local sphingomyelin clustering.

  19. A deficiency of SMS2 can diminish the extent of pulmonary edema and lung injury.

  20. SMS2 (Sphingomyelin synthase 2) physiologically contributes to de novo Sphingomyelin biosynthesis and plasma membrane Sphingomyelin levels

Sphingomyelin Synthase 2 (SGMS2) profil antigène

Antigen Summary

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.

Gene names and symbols associated with SGMS2

  • sphingomyelin synthase 2 (sgms2) anticorps
  • sphingomyelin synthase 2 (SGMS2) anticorps
  • sphingomyelin synthase 2 (Sgms2) anticorps
  • 4933405A16Rik anticorps
  • 5133401H06Rik anticorps
  • AI854299 anticorps
  • RGD1305778 anticorps
  • SMS2 anticorps
  • spermatin anticorps

Protein level used designations for SGMS2

sphingomyelin synthase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2-like , SM synthase

496853 Xenopus (Silurana) tropicalis
695947 Macaca mulatta
735414 Pan troglodytes
100072971 Equus caballus
100079264 Ornithorhynchus anatinus
100400486 Callithrix jacchus
100446194 Pongo abelii
100466473 Ailuropoda melanoleuca
100593842 Nomascus leucogenys
166929 Homo sapiens
556193 Danio rerio
422529 Gallus gallus
478505 Canis lupus familiaris
100518796 Sus scrofa
520954 Bos taurus
74442 Mus musculus
310849 Rattus norvegicus
100715504 Cavia porcellus
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