SplA/ryanodine Receptor Domain and SOCS Box Containing 1 Protéines (SPSB1)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). De plus, nous expédions SPSB1 Anticorps (12) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SPSB1 80176 Q96BD6
SPSB1 74646 Q9D5L7
SPSB1 504407 Q5E9X6
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Top SPSB1 Protéines sur anticorps-enligne.fr

Showing 6 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Escherichia coli (E. coli) Humain His tag 50 μg Connectez-vous pour afficher 15 to 19 Days
$492.31
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,713.33
Détails

SPSB1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Cow (Bovine)

Plus protéines pour SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) partenaires d'interaction

Human SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) interaction partners

  1. EGF (Montrer EGF Protéines) signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B (Montrer TCEB2 Protéines)/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1 (Montrer HNRNPA1 Protéines).

  2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  3. SSB1 (Montrer SSBP1 Protéines)/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.

Mouse (Murine) SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) interaction partners

  1. Collectively, Ssb1 and Ssb2 (Montrer SPSB2 Protéines) control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.

  2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  3. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.

  4. These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2 (Montrer SPSB2 Protéines), controls the extent of iNOS (Montrer NOS2 Protéines) induction and nitric oxide production.

  5. SPSB1 and SPSB4 (Montrer SPSB4 Protéines) bind strongly to both Par-4 (Montrer F2RL3 Protéines) and VASA (Montrer DDX4 Protéines) peptides.

  6. Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.

Profil protéine SPSB1

Profil protéine

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene names and symbols associated with SPSB1

  • splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1)
  • splA/ryanodine receptor domain and SOCS box containing 1 (Spsb1)
  • 1110014L01Rik Protéine
  • 4930422J18Rik Protéine
  • AI596360 Protéine
  • AI854583 Protéine
  • SSB-1 Protéine
  • SSB1 Protéine

Protein level used designations for SPSB1

SPRY domain-containing SOCS box protein 1 , SPRY domain-containing SOCS box protein SSB-1 , novel SPRY domain containing protein , SSB-1

GENE ID SPECIES
80176 Homo sapiens
74646 Mus musculus
504407 Bos taurus
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