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Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). De plus, nous expédions SPSB1 Anticorps (15) et beaucoup plus de produits pour cette protéine.
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EGF (Montrer EGF Protéines) signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B (Montrer TCEB2 Protéines)/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1 (Montrer HNRNPA1 Protéines).
SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.
SSB1 (Montrer SSBP1 Protéines)/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.
Collectively, Ssb1 and Ssb2 (Montrer SPSB2 Protéines) control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.
Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.
These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2 (Montrer SPSB2 Protéines), controls the extent of iNOS (Montrer NOS2 Protéines) induction and nitric oxide production.
SPSB1 and SPSB4 (Montrer SPSB4 Protéines) bind strongly to both Par-4 (Montrer F2RL3 Protéines) and VASA (Montrer DDX4 Protéines) peptides.
Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
SPRY domain-containing SOCS box protein 1
, SPRY domain-containing SOCS box protein SSB-1
, novel SPRY domain containing protein