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promotes cell adhesion and outgrowth of embryonic hippocampal neurons [RGD, Feb 2006].. De plus, nous expédions SPON2 Kits (27) et SPON2 Protéines (12) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal SPON2 Primary Antibody pour ELISA - ABIN523815
Murakoshi, Tanimoto, Gohda, Hagiwara, Takagi, Horikoshi, Tomino: Mindin: a novel marker for podocyte injury in diabetic nephropathy. dans Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
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Human Polyclonal SPON2 Primary Antibody pour ELISA, WB - ABIN4334535
Manda, Kohno, Matsuno, Takenoshita, Kuwano, Yokota: Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. dans Genomics 1999
Egr-1 (Montrer EGR1 Anticorps) regulates mindin expression by directly binding to the mindin promoter; mindin suppresses colon cancer progression by blocking angiogenesis.
Spondin-2 overexpression contributes to tumor aggressiveness and prognosis in gastric cancer.
SPON2 is a transcriptional target of the metastasis gene MACC1 (Montrer MACC1 Anticorps). SPON2 induces cell motility in vitro and CRC (Montrer CALR Anticorps) metastasis in mice. In patients, SPON2 serves as prognostic indicator for CRC (Montrer CALR Anticorps) metastasis and survival, and might represent a promising target for therapeutic approaches.
Data suggest that spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.
Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT (Montrer AKT1 Anticorps)-dependent manner.
Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa (Montrer FLVCR1 Anticorps)). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa (Montrer FLVCR1 Anticorps) patients with metastasis.
mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT (Montrer AKT1 Anticorps)/GSK3beta and TGF-beta1 (Montrer TGFB1 Anticorps)-Smad (Montrer SMAD1 Anticorps) signalling.
High Mindin is associated with diabetic nephropathy in type 2 diabetes.
Spondin 2, which is regulated by T(3), has an important role in cell invasion, cell migration, and hepatoma tumor progression.
The structure of the F-spondin (Montrer SPON1 Anticorps) domain of mindin was determined at 1.8-A resolution.
Mindin is a novel modulator of hepatic I/R injury through regulating inflammatory responses, as well as hepatocyte apoptosis and proliferation via inactivation of the Akt (Montrer AKT1 Anticorps) signaling pathway.
Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and insulin (Montrer INS Anticorps) resistance via its interaction with PPARalpha (Montrer PPARA Anticorps).
The data of this study demonstrated that mindin is a critical mediator of ischemic brain injury in an experimental stroke model.
Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.
Mindin expression is upregulated during intestinal inflammation and may induce NF-kappaBp65 promoter activation in a TLR-9 (Montrer TLR9 Anticorps) mediated manner.
Mindin is a pattern-recognition molecule for microbial pathogens.
Mindin-integrin interactions play a key role in regulating Rho GTPase (Montrer RACGAP1 Anticorps) expression in DCs and DC priming of T lymphocytes.
mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection.
mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease.
promotes cell adhesion and outgrowth of embryonic hippocampal neurons
differentially expressed in cancerous and non-cancerous lung cells 1
, spondin 2a, extracellular matrix protein