anti-Squalene Epoxidase (SQLE) Anticorps

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. De plus, nous expédions Squalene Epoxidase Kits (8) et Squalene Epoxidase Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SQLE 6713 Q14534
SQLE 20775 P52019
SQLE 29230 P52020
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Top anti-Squalene Epoxidase Anticorps sur anticorps-enligne.fr

Showing 10 out of 27 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Immunohistochemistry analysis in human testis tissue (Formalin-fixed, Paraffin-embedded) using Squalene epoxidase / SQLE Antibody (N-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SQLE antibody for IHC; Clinical relevance has not been evaluated. Western blot analysis in A549 cell line lysates (35ug/lane) using Squalene epoxidase / SQLE Antibody (N-term). This demonstrates the SQLE antibody detected the SQLE protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Immunohistochemistry: SQLE Antibody [NBP2-32001] - Staining of human placenta shows strong positivity in Decidual cells. Immunohistochemistry: SQLE Antibody [NBP2-32001] - Skin 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$439.69
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Squalene EpoxidasePolyclonal Antibody, Unconjugated (ABIN705401) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 3 to 7 Days
$295.90
Détails
Humain Lapin Inconjugué IHC (p), WB SQLE Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SQLE antibody detected the SQLE protein (arrow). SQLE Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SQLE Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué WB Western Blot analysis of SQLE expression in transfected 293T cell line by SQLE MaxPab polyclonal antibody.<br><br>Lane 1: SQLE transfected lysate(63.90 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Connectez-vous pour afficher 11 to 12 Days
$418.57
Détails
Humain Lapin Inconjugué IHC, WB SQLE antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Hepatocytes (arrows) in Human Liver. Magnification is at 400X SQLE antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Connectez-vous pour afficher 2 to 3 Days
$473.93
Détails
Humain Lapin Inconjugué WB   200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cells, using SQLE antibody. 100 μL Connectez-vous pour afficher 16 Days
$323.13
Détails
Humain Lapin Inconjugué IHC, ELISA, WB 50 μg Connectez-vous pour afficher 2 to 3 Days
$433.13
Détails

SQLE Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human ,
,

, , , , ,
Mouse (Murine)


Rat (Rattus)


anti-Squalene Epoxidase Anticorps mieux référencés

  1. Human Polyclonal SQLE Primary Antibody pour WB - ABIN948500 : Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. dans Human pathology 2013 (PubMed)

  2. Human Polyclonal SQLE Primary Antibody pour IHC, IHC (p) - ABIN4355785 : Nguyen, Barozzi, Faronato, Lombardo, Steel, Patel, Darbre, Castellano, Győrffy, Woodley, Meira, Patten, Vircillo, Periyasamy, Ali, Frige, Minucci, Coombes, Magnani: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. dans Nature communications 2015 (PubMed)

Plus d’anticorps contre Squalene Epoxidase partenaires d’interaction

Human Squalene Epoxidase (SQLE) interaction partners

  1. Both HMGCR (Montrer HMGCR Anticorps) and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 (Montrer SREBF2 Anticorps) homodimer.

  2. Higher Gleason grade was associated with lower LDLR (Montrer LDLR Anticorps) expression, lower SOAT1 (Montrer SOAT1 Anticorps) and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR (Montrer LDLR Anticorps) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (Montrer SOAT1 Anticorps) expression (odds ratio, 0.41; 95% CI 0.21-0.83).

  3. Data indicate that microRNA miR (Montrer MLXIP Anticorps)-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).

  4. our results pinpoint SQLE as a bona fide metabolic oncogene (Montrer RAB1A Anticorps) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.

  5. this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.

  6. overexpression of SQLE in HCC (Montrer FAM126A Anticorps) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.

  7. Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (Montrer MARCH6 Anticorps) (membrane-associated ring finger (Montrer PCGF1 Anticorps) [C3HC4] 6).

  8. MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.

  9. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (Montrer IGFBP5 Anticorps), SQLE, RAP2B (Montrer RAP2B Anticorps), CLDN1 (Montrer CLDN1 Anticorps), and TBL1XR1 (Montrer TBL1XR1 Anticorps).

  10. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox (Montrer COX8A Anticorps) analysis in two independent patient cohorts of 160 patients each

Mouse (Murine) Squalene Epoxidase (SQLE) interaction partners

  1. Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.

  2. results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.

  3. Requires a redox partner, but cytochrome p450 reductase (Montrer POR Anticorps) is not the only microsomal reductase that will serve this purpose.

Squalene Epoxidase (SQLE) profil antigène

Profil protéine

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.

Gene names and symbols associated with SQLE

  • squalene epoxidase (SQLE) anticorps
  • squalene epoxidase (ANI_1_450034) anticorps
  • squalene epoxidase (AOR_1_1218114) anticorps
  • squalene epoxidase (CC1G_03987) anticorps
  • squalene epoxidase (BDBG_08449) anticorps
  • squalene epoxidase (MCYG_02365) anticorps
  • squalene epoxidase (TERG_05717) anticorps
  • squalene epoxidase (Sqle) anticorps
  • AI323792 anticorps
  • An03g03770 anticorps
  • AO090701000685 anticorps

Protein level used designations for SQLE

squalene epoxidase , squalene monooxygenase , SE

GENE ID SPECIES
100067615 Equus caballus
4980366 Aspergillus niger CBS 513.88
5995549 Aspergillus oryzae RIB40
6007557 Coprinopsis cinerea okayama7130
8508601 Ajellomyces dermatitidis SLH14081
9226506 Arthroderma otae CBS 113480
10376061 Trichophyton rubrum CBS 118892
100125351 Ovis aries
6713 Homo sapiens
608021 Canis lupus familiaris
100113409 Sus scrofa
526535 Bos taurus
20775 Mus musculus
29230 Rattus norvegicus
420335 Gallus gallus
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