anti-Squalene Epoxidase (SQLE) Anticorps

Human Squalene Epoxidase (SQLE) interaction partners

1. Taken together, our results support a model whereby the amphipathic helix in squalene monooxygenase N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal.

2. Both HMGCR (Montrer HMGCR Anticorps) and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 (Montrer SREBF2 Anticorps) homodimer.

3. Higher Gleason grade was associated with lower LDLR (Montrer LDLR Anticorps) expression, lower SOAT1 (Montrer SOAT1 Anticorps) and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR (Montrer LDLR Anticorps) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (Montrer SOAT1 Anticorps) expression (odds ratio, 0.41; 95% CI 0.21-0.83).

4. Data indicate that microRNA miR (Montrer MLXIP Anticorps)-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).

5. our results pinpoint SQLE as a bona fide metabolic oncogene (Montrer RAB1A Anticorps) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.

6. this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.

7. overexpression of SQLE in HCC (Montrer FAM126A Anticorps) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.

8. Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (Montrer MARCH6 Anticorps) (membrane-associated ring finger (Montrer PCGF1 Anticorps) [C3HC4] 6).

9. MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.

10. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (Montrer IGFBP5 Anticorps), SQLE, RAP2B (Montrer RAP2B Anticorps), CLDN1 (Montrer CLDN1 Anticorps), and TBL1XR1 (Montrer TBL1XR1 Anticorps).

Mouse (Murine) Squalene Epoxidase (SQLE) interaction partners

1. Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.

2. results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.

3. Requires a redox partner, but cytochrome p450 reductase (Montrer POR Anticorps) is not the only microsomal reductase that will serve this purpose.