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Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity).. De plus, nous expédions Src-Like-Adaptor Kits (6) et Src-Like-Adaptor Protéines (6) et beaucoup plus de produits pour cette protéine.
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results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases
Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit (Montrer KIT Anticorps) signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit (Montrer KIT Anticorps) bypasses the normal cellular negative feedback control
upon ligand stimulation SLAP stably associates with Flt3 (Montrer FLT3 Anticorps) through multiple phosphotyrosine residues in Flt3 (Montrer FLT3 Anticorps). SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3 (Montrer FLT3 Anticorps)-ITD mutation
These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.
Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids.
The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution.
SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke
SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection.
Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (Montrer CSF2RA Anticorps) (GM-CSFR (Montrer CSF2RA Anticorps)) generation of monocyte-derived dendritic cells of bone marrow origin.
SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70 (Montrer ZAP70 Anticorps)) Src-like adapter protein (SLAP) knockout mouse model.
SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors.
SLAP functions in a pathway that requires the phosphorylated TCRzeta (Montrer CD247 Anticorps) chain and the Src (Montrer SRC Anticorps) family kinase Lck (Montrer LCK Anticorps), but not ZAP-70 (Montrer ZAP70 Anticorps) (zeta-associated protein of 70 kD).
SLAP has a conserved function in B and T cells by adapting c-Cbl (Montrer CBL Anticorps) to the antigen-receptor complex and targeting it for degradation
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity).
, src-like-adapter protein 1
, src-like adaptor
, src-like adapter protein
, src-like adaptor protein