Sterol O-Acyltransferase 1 (SOAT1) Kits ELISA

The protein encoded by SOAT1 belongs to the acyltransferase family. De plus, nous expédions SOAT1 Anticorps (34) et SOAT1 Protéines (7) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SOAT1 6646 P35610
Anti-Souris SOAT1 SOAT1 20652 Q61263
Anti-Rat SOAT1 SOAT1 81782 O70536
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  2 x 96 Tests 1 to 2 Days

Plus Kits ELISA pour SOAT1 partenaires d'interaction

Human Sterol O-Acyltransferase 1 (SOAT1) interaction partners

  1. There was a significant difference and a higher frequency of AA and AC genotypes (p = 0.047 and p = 0.016, respectively) of the SOAT1 (ACAT-1) gene in asymptomatic chagasic individuals.

  2. the transcription factor signal transducer and activator of transcription 3 was activated by TB-PE, and its chemical inhibition prevented the accumulation of lipid bodies and ACAT expression in macrophages. In terms of the host immune response, TB-PE-treated macrophages displayed immunosuppressive properties and bore higher bacillary loads.

  3. Soat-1 role in atherosclerosis

  4. Several residues in one subunit closely interact with the same residues in the other subunit; mutating these res. to Cys does not lead to loss in enzyme activity. Mutating residues F453, A457, or H460 to Cys causes large loss in enzyme activity.

  5. increase in the in vitro ACAT1 activity in PC-3 prostate cancer cells treated with androgen

  6. The results suggest that rs1044925 polymorphism in ACAT1 gene is not only associated with serum LDL-C and nHDLC levels in healthy Chinese subjects in Chengdu area, but also with HDL-C level in subjects with endogenous hypertriglyceridemia.

  7. RNA secondary structures located in the vicinity of the GGC(1274-1276) codon are required for production of the 56-kDa isoform.

  8. ACAT inhibition may stimulate cholesterol-catabolic (cytochrome P450) pathway in lesion-macrophages.

  9. Angiotensin II enhances foam cell formation by upregulating ACAT1 expression predominantly through the actions of AT(1) receptor via the G protein/c-Src/PKC/MAPK pathway in human monocyte-macrophages

  10. Docosahexaenoic acid can act as a substrate for ACAT1. In the manner of a poor substrate, docosahexaenoic acid also inhibited the activity of ACAT1.

  11. Results suggest that the ERK, p38MAPK and JNK signaling pathways may be involved in insulin-mediated regulation of ACAT1, but no PI3K and PLC-gamma signaling pathways were involved in the present study.

  12. Leptin accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression.

  13. High ACAT1 expression is associated with estrogen receptor negative basal-like breast cancer.

  14. Macrophages cope with cholesterol loading by using a novel mechanism: they produce more ER-derived vesicles with elevated ACAT1 enzyme activity without having to produce more ACAT1 protein.

  15. the plaque-modulating effects of K-604 can be explained by stimulation of procollagen production independent of ACAT inhibition in addition to potent inhibition of macrophage ACAT-1

  16. Visfatin may down-regulate the ABCA1 expression and up-regulate the ACAT1 expression via PPARgamma signal transduction pathway, which decreases the outflow of free cholesterol, increases the content of cholesterol esters, and then induces foam cell formation.

  17. In THP-1-derived macrophages and foam cells, the expression level of ACAT-1 and cellular cholesterol content increased significantly in response to asymmetric dimethylarginine treatment in a time- and concentration-dependent manner.

  18. The present study shows that the C allele carriers of ACAT-1 rs1044925 SNP in male hyperlipidemic subjects had higher serum total cholesterol, HDL-cholesterol and ApoAI levels than the C allele noncarriers.

  19. Essential oil of Pinus koraiensis leaves significantly inhibited hACAT1 levels in HepG2 cells.

  20. Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels.

Mouse (Murine) Sterol O-Acyltransferase 1 (SOAT1) interaction partners

  1. NLRP3 is involved in the aggravation of cutaneous xanthomatosis and atherosclerosis in mice with bone marrow ACAT1 deficiency.

  2. loss of ACAT1 in bone marrow-derived cells attenuates atherosclerosis, which is aggravated by the loss of NCEH1

  3. blocking Soat1 (ACAT-1) suppresses diet-induced obesity in part by slowing down monocyte infiltration to white adipose tissue as well as by reducing the inflammatory responses of adipose tissue macrophage

  4. results demonstrate that ACATs are required for storage ability of lipids and cholesterol in adipocytes

  5. Soat-1 role in atherosclerosis

  6. SOAT1 plays an important role in hypothalamic insulin sensitivity, linked to cognitive impairment, in high fat diet-fed mice.

  7. a potential regulatory relationship between the sterol O-acetyltransferase 1 gene and Hoxc13 gene

  8. A potentially novel gene or known gene with a novel phenotype resides within this interval, which may shed light on human diseases with defects in the inner structure of the hair fibre.

  9. Soat1 is a quantitative trait loci gene contributing to hyperlipidemia.

  10. soat1 had an important role in normal hair formation

  11. ACAT1 activity plays a central role in the proper trafficking of cholesterol and in cholesterol-sensing in the macrophage.

SOAT1 profil antigène

Antigen Summary

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with SOAT1

  • sterol O-acyltransferase 1 S homeolog (soat1.S) anticorps
  • sterol O-acyltransferase 1 (SOAT1) anticorps
  • sterol O-acyltransferase 1 (soat1) anticorps
  • sterol O-acyltransferase 1 (CpipJ_CPIJ019799) anticorps
  • sterol O-acyltransferase 1 (PTRG_01998) anticorps
  • sterol O-acyltransferase 1 (PTRG_00080) anticorps
  • sterol O-acyltransferase 1 (Smp_134390) anticorps
  • sterol O-acyltransferase (CNF01130) anticorps
  • sterol O-acyltransferase (CC1G_00886) anticorps
  • sterol O-acyltransferase 1 (Soat1) anticorps
  • 8430426K15Rik anticorps
  • Acact anticorps
  • Acat anticorps
  • Acat-1 anticorps
  • ACAT1 anticorps
  • ald anticorps
  • AW550831 anticorps
  • hid anticorps
  • si:dkey-21p1.4 anticorps
  • SOAT anticorps
  • STAT anticorps

Protein level used designations for SOAT1

sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 , sterol O-acyltransferase 1 , sterol O-acyltransferase 1-like , sterol O-acyltransferase , acyl-coenzyme A:cholesterol acyltransferase 1 , acyl coenzyme A:cholesterol acyltransferase 1 , adrenocortical lipid depletion , cholesterol acyltransferase 1 , acyltransferase wax synthase , Acyl-coenzyme A:cholesterol acyltransferase 1 , Cholesterol acyltransferase 1

446863 Xenopus laevis
457553 Pan troglodytes
564424 Danio rerio
6054215 Culex quinquefasciatus
6339839 Pyrenophora tritici-repentis Pt-1C-BFP
6339947 Pyrenophora tritici-repentis Pt-1C-BFP
8345136 Schistosoma mansoni
100022219 Monodelphis domestica
100145286 Xenopus (Silurana) tropicalis
100436698 Pongo abelii
3258377 Cryptococcus neoformans var. neoformans JEC21
6007810 Coprinopsis cinerea okayama7130
6646 Homo sapiens
20652 Mus musculus
81782 Rattus norvegicus
424424 Gallus gallus
490325 Canis lupus familiaris
100628166 Sus scrofa
504287 Bos taurus
100689317 Cricetulus griseus
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