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STAG1 is a member of the SCC3 family and is expressed in the nucleus.
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Human Polyclonal Stromal Antigen 1 Primary Antibody pour ICC, IF - ABIN151764
Zhang, Kuznetsov, Sharan, Li, Rao, Pati: A handcuff model for the cohesin complex. dans The Journal of cell biology 2008
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Here the authors demonstrate that the most frequently mutated subunit of the cohesin complex (Montrer SMC3 Anticorps), STAG2 (Montrer STAG2 Anticorps), displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 (Montrer STAG2 Anticorps) mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis.
This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders.
Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2 (Montrer STAG2 Anticorps)).
There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B.
Data support the hypothesis that CTCF (Montrer CTCF Anticorps) and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis.
TRF1 (Montrer TERF1 Anticorps) tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 (Montrer TERF1 Anticorps) together form longer DNA-DNA pairing tracts than with TRF1 (Montrer TERF1 Anticorps) alone, as revealed by atomic force microscopy imaging
Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 (Montrer STAG2 Anticorps) expressed in Saccharomyces cerevisiae.
Mutations in STAG1 is associated with acute myeloid leukemia (Montrer BCL11A Anticorps).
cohesin-SA1 and cohesin-SA2 (Montrer STAG2 Anticorps) participate in the DNA damage response
Rad21 (Montrer RAD21 Anticorps) binds to SA proteins through two SA-binding motifs on Rad21 (Montrer RAD21 Anticorps).
reduced dosage of SA1 altered the architecture of the Reg (Montrer KCNH2 Anticorps) locus and decreased the expression of Reg (Montrer KCNH2 Anticorps) genes in the pancreas of SA1 heterozygous mice
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.
stromal antigen 1
, SCC3 homolog 1
, cohesin subunit SA-1
, nuclear protein stromal antigen 1
, cohesin subunit XSA1
, stromal antigen 1 homolog