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SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008].. De plus, nous expédions SMC1B Anticorps (29) et beaucoup plus de produits pour cette protéine.
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Through the translational regulation of novel RNA targets SMC1B and TEX11 (Montrer TEX11 Protéines), DAZL (Montrer DAZL Protéines) may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.
Data show that structural maintenance of chromosomes protein 1B (SMC1B) is expressed in primary fibroblasts.
High SMC1B expression is associated with pancreatic cancer.
a novel function of Smc1beta as a spindle assembly checkpoint participant beyond its role in chromosome cohesion during mouse oocyte meiosis, identified.
super resolution microscopy revealed synapsis-associated SYCP1 (Montrer SYCP1 Protéines) aberrantly deposited between sister chromatids and on single chromatids in Smc1b-/-Rad21L (Montrer RAD21L1 Protéines)-/- cells.
Data show that structural maintenance of chromosomes protein 1B (Smc1b) is expressed in somatic cells.
Together with previous knowledge, three main functions of SMC1b have emerged, which have multiple consequences for spermatocyte biology.
We report here evidence from the mouse that partial loss of gene function for either Smc1b or Rec8 (Montrer REC8 Protéines) causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase
SMC1 beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II.
E2F6 silences SMC1beta and STAG3 in somatic cells
SMC1beta plays role in oogenesis.
In addition to its role in sister chromatid cohesion, Smc1beta determines meiotic chromatin loop organization.
A deletion of 16 nucleotides in exon 5 led to a frame-shift, which generated a stop codon at position 761 (amino acid 247) of the Smc1b cDNA in mutant mice.
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001
SMC protein 1B
, SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
, SMC1 structural maintenance of chromosomes 1-like 2
, mitosis-specific chromosome segregation protein like protein beta
, structural maintenance of chromosomes protein 1B
, structural maintenace of chromosomes 1B