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Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A\; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010].. De plus, nous expédions SMC2 Anticorps (76) et beaucoup plus de produits pour cette protéine.
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SMC2 (or the condensin complex) is a novel molecular target for the treatment of MYCN-amplified neuroblastoma.
analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition
SMC2 gene is altered by both frameshift mutation and loss of expression in gastric and colorectal cancers, suggesting that SMC2 gene alterations might be involved in pathogenesis of these cancers
WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery.
Studies indicate that tagged SMC2 subunit of the condensin complex with the streptavidin-Binding Peptide optimising efficacious use of this tag for protein analysis.
human SMC2 hinge domain with short coiled coils was cloned, expressed, purified and crystallized in the orthorhombic space group C222 in native and SeMet-derivatized forms
mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A\; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.
SMC protein 2
, SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
, XCAP-E homolog
, chromosome-associated protein E
, structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E
, structural maintenance of chromosomes protein 2
, FGF-inducible protein 16
, SMC2 structural maintenance of chromosomes 2-like 1
, fibroblast growth factor inducible 16
, chromosome assembly protein XCAP-E
, chromosome scaffold protein ScII