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SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. De plus, nous expédions Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Protéines (8) et et beaucoup plus de produits pour cette protéine.
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Human Monoclonal SUV39H1 Primary Antibody pour ChIP, IP - ABIN2668694
Terada: Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition. dans Molecular biology of the cell 2006
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Human Polyclonal SUV39H1 Primary Antibody pour IHC, IHC (p) - ABIN439327
Ayrapetov, Xu, Sun, Zhu, Parmar, DAndrea, Price: Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. dans PLoS ONE 2011
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Human Polyclonal SUV39H1 Primary Antibody pour WB - ABIN387991
Fujita, Watanabe, Ichimura, Tsuruzoe, Shinkai, Tachibana, Chiba, Nakao: Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. dans The Journal of biological chemistry 2003
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KMT1A positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A-GATA3 (Montrer GATA3 Anticorps)-STAT3 (Montrer STAT3 Anticorps) circuit, in which KMT1A could be a promising target for bladder cancer therapy.
Here, the authors demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H1 with constitutive heterochromatin in human cells.
Here the authors show that Suv39h1 chromodomain binds nucleic acids, and this binding is important for its function in heterochromatin assembly.
SirT6 (Montrer SIRT6 Anticorps) promotes cysteine ubiquitination in the PRE-SET domain of Suv39h1.
Our data show that the differential expression of SUV39H1 and SUV39H2 (Montrer SUV39H2 Anticorps) is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution
Overexpression of miR (Montrer MLXIP Anticorps)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.
KAT7 (Montrer MYST2 Anticorps)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.
Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha (Montrer CBX5 Anticorps) and gamma, and enhances HP1beta (Montrer CBX1 Anticorps) levels.
we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1
These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.
The authors show here that the mouse Suv39h2 (Montrer SUV39H2 Anticorps) enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA.
Suv39h1 plays a critical role in marking chromatin to silence stem/memory genes during CD8 (Montrer CD8A Anticorps)+ T effector terminal differentiation
Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin (Montrer FN1 Anticorps) and p21(WAF1 (Montrer CDKN1A Anticorps)) in mesangial cells
Activation of p38alpha (Montrer MAPK14 Anticorps) displaces KMT1A from MyoD (Montrer MYOD1 Anticorps) to initiate myogenic gene expression upon induction of myoblasts differentiation.
Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (Montrer CBX5 Anticorps) to the promoter of the ancestral Oct4 (Montrer POU5F1 Anticorps) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.
Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.
Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
These findings indicate that Suv39h1 enhances AP-2alpha (Montrer TFAP2A Anticorps)-mediated transcriptional repression of C/EBPalpha (Montrer CEBPA Anticorps) in an epigenetic manner and further inhibits adipocyte differentiation.
A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.
The identification of a histone H3 (Montrer HIST3H3 Anticorps) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.
These results suggest that Dnmt1 (Montrer DNMT1 Anticorps) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (Montrer DNMT1 Anticorps) and Suv39h1 help guide the terminal differentiation of particular tissues.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
histone-lysine N-methyltransferase SUV39H1
, su(var)3-9 homolog 1
, Su(var)3-9 homolog 1
, histone H3-K9 methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 1
, lysine N-methyltransferase 1A
, position-effect variegation 3-9 homolog
, H3-K9-HMTase 1
, Suv39h histone methyltransferase
, histone-lysine N-methyltransferase SUV39H1-A
, su(var)3-9 homolog 1-A
, suppressor of variegation 3-9 homolog 1
, suppressor of variegation 3-9 homolog 1-A
, suppressor of variegation 3-9-like 1a