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SYMPK encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. De plus, nous expédions Symplekin Protéines (8) et Symplekin Kits (4) et beaucoup plus de produits pour cette protéine.
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Data indicate rs56848936 in the gene symplekin protein (SYMPK) at 19q13.3, associated with colon cancer risk.
CPSF2 (Montrer CPSF2 Anticorps) and SYMPK, are RBFOX2 (Montrer RBM9 Anticorps) cofactors for both inclusion and exclusion of internal exons.
Symplekin interacts and co-localizes with both MOZ (Montrer MYST3 Anticorps) and MLL (Montrer MLL Anticorps) in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 (Montrer HOXA9 Anticorps) protein level but not of Hoxa9 (Montrer HOXA9 Anticorps) mRNA.
Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II (Montrer 0 Anticorps) carboxy-terminal domain (CTD) Ser (Montrer SIGLEC1 Anticorps) 5 phosphatase Ssu72 (Montrer SSU72 Anticorps) and a CTD Ser (Montrer SIGLEC1 Anticorps) 5 phosphopeptide
Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp (Montrer CKAP5 Anticorps)).
Data show that claudin-2 (Montrer CLDN2 Anticorps) expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 (Montrer CLDN2 Anticorps) down-regulation increased the transepithelial resistance and decreased cyclin D1 (Montrer CCND1 Anticorps) expression and ZONAB (Montrer CSDA Anticorps) nuclear localization.
symplekin has a role in HSF1 (Montrer HSF1 Anticorps) modulation of Hsp70 (Montrer HSP70 Anticorps) mRNA polyadenylation
The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes.
The symplekin/ZONAB (Montrer CSDA Anticorps) complex inhibits intestinal cell differentiation by the repression of AML1/Runx1 (Montrer RUNX1 Anticorps).
Authors propose a model in which the core cleavage complex formation is mediated by CPSF73 (Montrer CPSF3 Anticorps), CPSF100 (Montrer CPSF2 Anticorps), and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.
This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 (Montrer CPSF3 Anticorps) and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.
Here, we identify a new factor essential for polyadenylation, namely, symplekin, a CPEB and CPSF (Montrer CPSF2 Anticorps) binding protein that serves as a scaffold upon which regulatory factors are assembled
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
, hepatocyte nuclear factor 3 gamma
, LOW QUALITY PROTEIN: symplekin