anti-Synapsin I (SYN1) Anticorps

SYN1 is a member of the synapsin gene family. De plus, nous expédions Synapsin I Kits (36) et Synapsin I Protéines (11) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SYN1 6853 P17600
SYN1 24949 P09951
SYN1 20964 O88935
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Top anti-Synapsin I Anticorps sur anticorps-enligne.fr

Showing 10 out of 332 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), WB Synapsin I was detected in paraffin-embedded sections of human glioma tissues using rabbit anti- Synapsin I Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 ??g/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Western blot analysis of Synapsin I expression in rat brain extract ( Lane 1), mouse brain extract ( Lane 2), and SHG-44 whole cell lysates ( Lane 3). Synapsin I at 78KD was detected using rabbit anti- Synapsin I Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails
Humain Souris Inconjugué WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.53 KDa) . Dilution: 1:500~1000 100 μg Connectez-vous pour afficher 8 to 11 Days
$527.50
Détails
Humain Souris Inconjugué ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.53 KDa) . Dilution: 1:500~1000 100 μg Connectez-vous pour afficher 8 to 11 Days
$527.50
Détails
Humain Souris Inconjugué ELISA, FACS, ICC, IF, IHC, WB ELISA: Synapsin I Antibody (7H10G6)  - Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Flow Cytometry: Synapsin I Antibody (7H10G6)  - Analysis of Hela cells using SYN1 mouse mAb (green) and negative control (red). 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$516.98
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
$265.00
Détails
Humain Souris Inconjugué ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using SYN1 mAb against human SYN1 (AA: 362-511) recombinant protein. (Expected MW is 41.7 kDa) 0.1 mg Connectez-vous pour afficher 8 to 11 Days
$577.50
Détails
Humain Souris Inconjugué ELISA, ICC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using SYN1 mAb against human SYN1 (AA: 362-511) recombinant protein. (Expected MW is 41.7 kDa) 0.1 mg Connectez-vous pour afficher 8 to 11 Days
$577.50
Détails
Rat Lapin Inconjugué WB Western blots of rat cortex lysate showing specific labeling of the ~78k synapsin protein phosphorylated at Ser 62,67 (Control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown). Western blot of rat cortical lysate showing specific labeling of the ~78 kDa synapsin protein phosphorylated at Ser62,67 in the first lane (-).  Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide (not shown). 100 μL Connectez-vous pour afficher 3 to 4 Days
$508.20
Détails
Boeuf (Vache) Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of Synapsin 1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary anti Immunohistochemical analysis of Synapsin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Boeuf (Vache) Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of Synapsin 1 (pS9) staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Synapsin 1 (pS9) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Connectez-vous pour afficher 13 to 14 Days
$575.00
Détails

anti-Synapsin I Anticorps mieux référencés

  1. Human SYN1 Primary Antibody pour IHC - ABIN967121 : Sinha, Wang, Ruchalski, Levine, Krishnan, Lieberthal, Schwartz, Borkan: Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. dans American journal of physiology. Renal physiology 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SYN1 Primary Antibody pour IHC - ABIN967122 : Bonanomi, Menegon, Miccio, Ferrari, Corradi, Kao, Benfenati, Valtorta: Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 (PubMed)
    Show all 3 Pubmed References

  3. Rat (Rattus) Polyclonal SYN1 Primary Antibody pour WB - ABIN361494 : Jovanovic, Benfenati, Siow, Sihra, Sanghera, Pelech, Greengard, Czernik: Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. dans Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 9 Pubmed References

  4. Cow (Bovine) Polyclonal SYN1 Primary Antibody pour IHC (fro), IF - ABIN550225 : Jovanovic, Sihra, Nairn, Hemmings, Greengard, Czernik: Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 (PubMed)
    Show all 3 Pubmed References

  5. Cow (Bovine) Polyclonal SYN1 Primary Antibody pour WB - ABIN550183 : Kao, Song, Porton, Ming, Hoh, Abraham, Czernik, Pieribone, Poo, Greengard: A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. dans Nature neuroscience 2002 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal SYN1 Primary Antibody pour - ABIN546494 : Tokumitsu, Hatano, Inuzuka, Sueyoshi, Yokokura, Ichimura, Nozaki, Kobayashi: Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. dans The Journal of biological chemistry 2005 (PubMed)
    Show all 3 Pubmed References

  7. Cow (Bovine) Polyclonal SYN1 Primary Antibody pour WB - ABIN550180 : Feng, Chi, Blanpied, Xu, Magarinos, Ferreira, Takahashi, Kao, McEwen, Ryan, Augustine, Greengard: Regulation of neurotransmitter release by synapsin III. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 (PubMed)
    Show all 3 Pubmed References

  8. Cow (Bovine) Polyclonal SYN1 Primary Antibody pour WB - ABIN550182 : Sakurada, Kato, Nagumo, Hiraoka, Furuya, Ikuhara, Yamakita, Fukunaga, Miyamoto, Matsumura, Matsuo, Naito, Sasaki: Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. dans The Journal of biological chemistry 2002 (PubMed)
    Show all 3 Pubmed References

  9. Rat (Rattus) Polyclonal SYN1 Primary Antibody pour WB - ABIN152525 : Hansen, Ipsen, Schou-Pedersen, Lykkesfeldt, Tveden-Nyborg: Long term Westernized diet leads to region-specific changes in brain signaling mechanisms. dans Neuroscience letters 2018 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre Synapsin I partenaires d’interaction

Human Synapsin I (SYN1) interaction partners

  1. Authors identified the c.236 C > G/p.S79W mutation in SYN1 as causative for the non-syndromic ID of the MRX50 family. Accordingly, the in vitro characterization of S79W SynI clearly indicates that the mutation does not interfere with neurodevelopmental aspects, but perturbs spontaneous SV exocytosis, SV clustering and SV lateral mobility along axons.

  2. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype.

  3. Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release.

  4. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.

  5. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders.

  6. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles.

  7. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology.

  8. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.

  9. The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression.

  10. A conserved region of human and mouse SYN1 promoters contains cis-sites for the transcriptional activator Sp1 in close proximity to REST binding motifs.

  11. The allelic frequencies of SYN1 are associated with Korean female schizophrenia.

  12. SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function.

  13. the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia.

  14. The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients.

  15. The results showed that synapsin I was significantly decreased in the stratum radiatum of CA1 subfield and the molecular layer of DG in AD patients.

  16. SYN1 nonsense mutation is the likely cause of epileptic and other phenotypes

  17. Synapsins and S100A1 interact in nerve terminals where coexpresssed; S100A1 cannot bind SV-associated synapsin I and may function as a cytoplasmic store of monomeric synapsin I; synapsin dimerization and interaction with S100A1 are mutually exclusive

  18. This study concluded that the human synapsin I gene is positively regulated by nuclear respiratory factor 1 and mediates the function of nuclear respiratory factor 1 in neurite outgrowth.

Mouse (Murine) Synapsin I (SYN1) interaction partners

  1. Results implicate SYN1 in the pathogenesis of non-syndromic intellectual disability, showing that alterations of synaptic vesicle trafficking are one possible cause of this disease, and suggest that distinct mutations in SYN1 may lead to distinct brain pathologies.

  2. This study demonstrated that syn1 affect the rate of release of GABA quanta residing within the Hippocampal Interneurons.

  3. Synapsin I is localized and produced at mature axon terminals and at immature growth cones.

  4. HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab

  5. Functions of synapsins in corticothalamic facilitation: important roles of synapsin I

  6. Levels of synapsin Ia/b increased in contralateral visual cortex following monocular deprivation.

  7. SynI mRNA and protein levels are down-regulated in the hippocampus of naive and Morris water maze-treated En2-/- mice.

  8. age-dependent reduction of phospho-synapsin-Ia reversed by exercise regimen

  9. This study demonostrated that Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex.

  10. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles.

  11. during chronic modification of neuronal activity and is an essential downstream effector for the Cdk5-mediated homeostatic scaling.

  12. O-GlcNAcylation of Thr-87 interferes with folding of the ALPS motif, providing a means for regulating the association of synapsin I with SVs as a mechanism contributing to synapsin I localization and RPSV generation.

  13. Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology.

  14. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.

  15. This study demonstrated a seizure-inducing potential of regular handling in both Syn1KO and Syn2KO mice during a period between P21 and 4 1/2 months of age.

  16. the serine residue at 605 of the synapsin-1 peptide, 603QASQAGPGPR612, and the serine residue at 692 of the tau peptide, 688SPVVSGDTSPR698, were found to be potential reciprocal O-GlcNAcylation and phosphorylation sites.

  17. Synapsin I knock-out mice do not exhibit a linear progression of the epileptic seizure phenotype.

  18. post-receptor calcium-dependent mechanisms associated with nicotine withdrawal are mediated through beta2-containing nicotinic receptors.

  19. NPAS4 plays an important role in the structural and functional plasticity of neurons

  20. A conserved region of human and mouse SYN1 promoters contains cis-sites for the transcriptional activator Sp1 in close proximity to REST binding motifs.

Cow (Bovine) Synapsin I (SYN1) interaction partners

  1. These results raise the possibility that Ser(603) on synapsin I is alternatively phosphorylated by p21-activated kinases, not only by CaMKII, in neuronal cells in response to some stimulants.

  2. Synapsin acts as a phosphorylation-modulated mediator of feedback regulation of Gz signaling by the synaptic machinery

  3. Synapsin-Rab3 interaction may participate in the regulation of synaptic vesicle trafficking within the nerve terminals.

  4. Interacts with rab3 protein; this interaction is likely to play a major role in the modulation of neurotransmitter release.

Pig (Porcine) Synapsin I (SYN1) interaction partners

  1. This study reports molecular cloning and characterization of the coding sequence of the porcine ortholog of syn I, including identification and verification at the protein level of an alanine-encoding insert.

Synapsin I (SYN1) profil antigène

Profil protéine

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with anti-Synapsin I (SYN1) Anticorps

  • synapsin I (SYN1) anticorps
  • synapsin I (Syn1) anticorps
  • synapsin I L homeolog (syn1.L) anticorps
  • synapsin I (syn1) anticorps
  • si:dkey-90n12.3 anticorps
  • Syn-1 anticorps
  • SYN1a anticorps
  • SYN1b anticorps
  • SYNI anticorps
  • SYN I anticorps

Protein level used designations for anti-Synapsin I (SYN1) Anticorps

brain protein 4.1 , synapsin-1 , synapsin 1 , synapsin I

GENE ID SPECIES
6853 Homo sapiens
24949 Rattus norvegicus
20964 Mus musculus
281510 Bos taurus
399153 Xenopus laevis
570672 Danio rerio
100017646 Monodelphis domestica
100216310 Sus scrofa
100685486 Canis lupus familiaris
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