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plays a role in clathrin-dependent assembly of synaptic vesicles at the presynaptic terminal. De plus, nous expédions SNAP91 Anticorps (31) et et beaucoup plus de produits pour cette protéine.
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Confinement within the presynaptic bouton is mediated in part by synaptic vesicle protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins.
The clathrin assembly role of AP180 is mediated by a long disordered C-terminal assembly domain.
Study concludes that the novel clathrin interaction sites identified here in CALM and AP180 have a major role in how these proteins interface with clathrin. This work advances the case that AP180 and CALM are required to use a combination of standard clathrin N-terminal domain binding motifs and the sequence identified here for optimal binding and assembling clathrin.
To sustain efficient neurotransmission and synaptic vesicle formation, AP180 and VAMP2 (Montrer VAMP2 Kits ELISA) are required.
AP180 and CALM are endocytic adaptors dedicated to the sorting of small soluble N-ethylmaleimide-sensitive-factor (Montrer NSF Kits ELISA) attachment protein receptors. (Review)
unique mechanism of SNARE motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 and CALM as cargo-specific adaptors for synaptobrevin endocytosis
AP180 is significantly decreased in the hippocampus of Alzheimer's disease patients and in hippocampal neurons of transgenic mice.
RNA interference-mediated knockdown of AP180 reduces the generation of Abeta1-40 and Abeta1-42, whereas CALM knockdown has no effect on Abeta (Montrer APP Kits ELISA) generation.
AP180 had an overall expression similar to synaptophysin (Montrer SYP Kits ELISA), the immunoreactivity for the two proteins did not always co-localize.
plays a role in clathrin-dependent assembly of synaptic vesicles at the presynaptic terminal
91 kDa synaptosomal-associated protein
, assembly protein, 180kDa
, clathrin coat assembly protein AP180
, clathrin coat-associated protein AP180
, phosphoprotein F1-20
, synaptosomal-associated protein, 91kDa homolog
, assembly protein 180 (AP180)
, synaptosomal-associated protein 91 kDa
, synaptosomal-associated protein, 91 kDa