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The product of STX2 belongs to the syntaxin/epimorphin family of proteins. De plus, nous expédions Syntaxin 2 Kits (12) et Syntaxin 2 Protéines (12) et beaucoup plus de produits pour cette protéine.
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Hamster Polyclonal STX2 Primary Antibody pour ICC, IP - ABIN1742219
Arasaki, Roy: Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. dans Traffic (Copenhagen, Denmark) 2010
Show all 4 Pubmed References
TGF-beta (Montrer TGFB1 Anticorps), bFGF (Montrer FGF2 Anticorps) and epimorphin in the extracellular microenvironment cooperatively affect HSF (Montrer HSF1 Anticorps) behaviors under the control of a highly sulfated (Montrer SULF1 Anticorps) chondroitin sulfate
The effects of HIV/HCV co-infection on hepatic fibrosis might be mediated in part by epimorphin (EPM). Strategies to limit the expression of EPM might represent a novel therapeutic approach to prevent the progression of hepatic fibrosis during HIV/HCV co-infection.
Identify 3 loci associated with circulating tPA (Montrer PLAT Anticorps) levels, the PLAT (Montrer PLAT Anticorps) region, STXBP5 (Montrer STXBP5 Anticorps), and STX2. Functional studies implicate a novel role for STXBP5 (Montrer STXBP5 Anticorps) and STX2 in regulating tPA (Montrer PLAT Anticorps) release.
Epimorphin can revert ovarian cancer cells away from their mesenchymal phenotype and toward an epithelial phenotype.
epimorphin modulates the signaling pathways mediated by EGFR (Montrer EGFR Anticorps) for epidermal tissue organization
Genetic variation in STX2 is associated with von Willebrand factor:Ag levels in patients diagnosed with type 1 von Willebrand Disease.
EPM, secreted by activated stellate cells within stroma, promotes invasion and metastasis of hepatocellular cancer cells by activating MMP-9 (Montrer MMP9 Anticorps) expression through the FAK (Montrer PTK2 Anticorps)-ERK (Montrer EPHB2 Anticorps) pathway.
Genetic variability in STXBP5 (Montrer STXBP5 Anticorps) and STX2 affects both VWF (Montrer VWF Anticorps) concentration and activity in young individuals with premature arterial thrombosis.
Munc18b (Montrer STXBP2 Anticorps) binds to syntaxins 1A, 2, and 3 and regulates vesicle transport to the apical plasma membrane
These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2 (Montrer MMP2 Anticorps), which is an important proteolytic factor in lung remodeling.
Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin (Montrer INS Anticorps) secretion. The increase in insulin (Montrer INS Anticorps) exocytosis was attributed mainly to an enhanced recruitment of the larger pool of newcomer secretory granules (SGs (Montrer SKI Anticorps)) that undergoes no residence time on plasma membrane before fusion and, to a lesser extent, also the predocked SGs (Montrer SKI Anticorps).
The selectivity in syntaxin binding and apical protein (Montrer SHROOM1 Anticorps) redistribution further suggests that rab17 (Montrer RAB17 Anticorps) and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface.
It was concluded that Epim deletion inhibits polyposis in Apcmin/+ mice, associated with increased mucosal TGF-beta (Montrer TGFB1 Anticorps) signaling and decreased myofibroblast HGF (Montrer HGF Anticorps) expression and secretion.
Overexpression of Epim expression is associated with mammary carcinoma.
These results suggest that STX2 plays roles in transport and/or subcellular distribution of sulfoglycolipids.
Epimorphin regulates bile duct formation via effects on mitosis orientation
Epimorphin has a pivotal role in the repair of renal fibrosis by modulating both extracellular matrix (ECM (Montrer MMRN1 Anticorps)) degradation and its production.
syntaxin 2 enters the membrane of a fused zymogen granule after the opening of the fusion pore
Epimorphin is involved in tissue repair following a single injection of carbon tetrachloride, in which distribution and the quantity of epimorphin expression are important, particularly in maintaining hepatocyte function.
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.
, syntaxin 1B2
, syntaxin 2