Syntaxin Binding Protein 5 (Tomosyn) Protéines (STXBP5)

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. De plus, nous expédions STXBP5 Anticorps (8) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
STXBP5 134957 Q5T5C0
STXBP5 78808  
Rat STXBP5 STXBP5 81022 Q9WU70
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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STXBP5 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) partenaires d'interaction

Human Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) interaction partners

  1. Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A (Montrer STX1A Protéines) and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein (Montrer PVALB Protéines) secretagogin (Montrer SCGN Protéines), which dissociates from tomosyn1 in response to Ca(2 (Montrer CA2 Protéines)+)-raising stimuli and is required for insulin (Montrer INS Protéines) granule trafficking and exocytosis downstream of Ca(2 (Montrer CA2 Protéines)+) influx.

  2. Using CRISPR/Cas9 genome editing, identified a human nonsynonymous SNP rs1039084 in the STXBP5 locus as a causal variant for a decreased thrombotic phenotype.

  3. Genetic variations in STXBP5 and CLEC4M (Montrer CLEC4M Protéines) are associated with VWF (Montrer VWF Protéines) level variation in type 1, but not in type 2 von Willebrand disease.

  4. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  5. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  6. Identify 3 loci associated with circulating tPA (Montrer PLAT Protéines) levels, the PLAT (Montrer PLAT Protéines) region, STXBP5, and STX2 (Montrer STX2 Protéines). Functional studies implicate a novel role for STXBP5 and STX2 (Montrer STX2 Protéines) in regulating tPA (Montrer PLAT Protéines) release.

  7. Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients.

  8. Genetic variation in STXBP5 gene is associated with venous thrombosis.

  9. multiple domains outside the R-SNARE (Montrer YKT6 Protéines) of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion

  10. Genetic variability in STXBP5 and STX2 (Montrer STX2 Protéines) affects both VWF (Montrer VWF Protéines) concentration and activity in young individuals with premature arterial thrombosis.

Mouse (Murine) Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) interaction partners

  1. Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed.

  2. Mouse Embryonic Stem (mES (Montrer PTCH1 Protéines)) cells self-differentiated into arginine vasopressin (AVP (Montrer AVP Protéines)) neurons (mES (Montrer PTCH1 Protéines)-AVP (Montrer AVP Protéines)) that expressed tomosyn and two transmembrane SNARE (Montrer VTI1B Protéines) proteins, including SNAP25 (Montrer SNAP25 Protéines) and syntaxin1 (Montrer STX1A Protéines). Tomosyn negatively regulates arginine vasopressin (Montrer AVP Protéines) secretion in embryonic stem cell-derived neurons.

  3. PIASgamma-dependent modification of tomosyn-1 with SUMO-2 (Montrer SUMO2 Protéines)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.

  4. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  5. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  6. regulates SNARE (Montrer VTI1B Protéines) complex formation and synaptic vesicle fusion. (review)

  7. Interacts with SNAP23 (Montrer SNAP23 Protéines) and Syntaxin4 (Montrer STX4 Protéines) and plays a role in Insulin (Montrer INS Protéines)-stimulated GLUT4 (Montrer SLC2A4 Protéines) translocacion.

  8. The interaction between syntaxin4 (Montrer STX4 Protéines) and Munc18c (Montrer STXBP3 Protéines) in adipocytes results in enhancement of insulin (Montrer INS Protéines)-stimulated GLUT4 (Montrer SLC2A4 Protéines) externalization.

  9. In the pancreatic beta-cell, tomosyn negatively regulates insulin (Montrer INS Protéines) exocytosis.

  10. Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin (Montrer INS Protéines) secretagogues.

Profil protéine STXBP5

Profil protéine

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with STXBP5

  • syntaxin binding protein 5 (STXBP5)
  • syntaxin binding protein 5 (tomosyn) (Stxbp5)
  • syntaxin binding protein 5 (Stxbp5)
  • 0710001E20Rik Protéine
  • 4930565N16Rik Protéine
  • AW742610 Protéine
  • LGL3 Protéine
  • LLGL3 Protéine
  • mKIAA1006 Protéine
  • Nbla04300 Protéine

Protein level used designations for STXBP5

lethal(2) giant larvae protein homolog 3 , putative protein product of Nbla04300 , syntaxin-binding protein 5 , tomosyn , tomosyn-1 , tomosyn 1

GENE ID SPECIES
134957 Homo sapiens
78808 Mus musculus
81022 Rattus norvegicus
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