T-Complex Protein 1 (TCP1) Kits ELISA

TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. De plus, nous expédions T-Complex Protein 1 Anticorps (191) et T-Complex Protein 1 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
TCP1 21454 P11983
TCP1 8626 Q9H3D4
TCP1 246334 Q9JJP6
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
  2 x 96 Tests 2 to 3 Days
  2 x 96 Tests 2 to 3 Days
  96 Tests 26 to 36 Days
  96 Tests 2 to 3 Days

Plus Kits ELISA pour T-Complex Protein 1 partenaires d'interaction

Mouse (Murine) T-Complex Protein 1 (TCP1) interaction partners

  1. chaperonin-containing TCP-1 complex required for lysosomal functioning and autophagosome degradation

  2. The authors identify and confirm interaction of M72 with the eukaryotic chaperonin tailless complex protein -1 (TCP-1) ring complex (TRiC) or chaperonin containing tailless complex polypeptide 1 (CCT). Accumulating biochemical evidence indicates M72 forms homo-oligomers and is a substrate of TRiC/CCT

  3. treating BACHD cortical neurons with ApiCCT1 prevented BACHD striatal neuronal atrophy by enhancing release of BDNF that subsequently acts through tyrosine receptor kinase B (TrkB) receptor on striatal neurons. Our findings are evidence that TRiC reagent-mediated reductions in mHTT enhanced BDNF delivery to restore the trophic status of BACHD striatal neurons.

  4. this study shows that CCTalpha is required for antigen-specific, germinal center-derived memory B cells

  5. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (P2X7R) and plays a role in lymphoid neoplasm metastasis.

  6. The data presented here reveal an additional level of interplay between CCT and actin mediated via gelsolin, suggesting that CCT may influence processes depending on gelsolin activity, such as cell motility.

  7. Host CCTalpha is required for efficient transcription and replication of rabies virus.

  8. Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia

  9. Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.

  10. Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.

  11. TRiC-peptide complexes of the heat shock protein 60 family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC purified from a tumor elicits specific protection against a challenge with that tumor.

  12. the membrane binding domain of CTP:phosphocholine cytidylyltransferase has a role in alveolar type II cells

  13. downregulated expression in T cells following treatment with bis(tri-n-butylin)oxide (TBTO), an immunotoxic organotin

  14. cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions

Human T-Complex Protein 1 (TCP1) interaction partners

  1. Ablation of DeltaNp63 alpha leads to cell cycle arrest and growth retardation, due to, in part, upregulation of p38 MAPK phosphorylation and activation.

  2. Overexpression of DeltaNp63gamma modulates cell invasion by inducing targetable SRC-Slug-evoked epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma , which can be reversed by inhibitors of the SRC signaling.

  3. p38alpha destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential

  4. The data illuminate a novel axis regulating cell senescence: DeltaNp63alpha stimulates transcription of E3 ligase HERC3, which mediates ubiquitination of c-Myc modulator MM1 and targets it to proteasomal degradation; subsequently, c-Myc is derepressed by DeltaNp63alpha, thereby cell senescence is modulated by this axis.

  5. CKAP4 has a role in esophageal cancer cell proliferation through p63 dependent DKK3 expression

  6. We identified rare damaging variants in four genes known to be mutated in syndromic lip and/or cleft palate (syCL/P) : TP63 (one family), TBX1 (one family), LRP6 (one family) and GRHL3 (two families), and clinical reassessment confirmed the isolated nature of their lip and/or cleft palate (CL/P).

  7. These results showed tumor-suppressive roles of DeltaNp63beta and miR-205 by inhibiting epithelial-to-mesenchymal transition (EMT) thorough modulating ZEB1 and ZEB2 expression in oral squamous cell carcinoma

  8. we found that human lung epithelial (HuL) cells, derived from normal, peripheral lung tissue, in monolayer, mostly express both the N-terminally truncated isoform of p63 (Np63), a marker for airway basal cells, and thyroid transcription factor-1 (TTF-1), a marker for alveolar epithelial cells, even though these two molecules are usually expressed in a mutually exclusive way.

  9. These findings identify a unique crosstalk between DeltaNp63+ TNBC cells and MDSCs that promotes tumor progression and metastasis, which could be exploited in future combined immunotherapy/chemotherapy strategies for TNBC patients.

  10. Study comparing p63/p40 expression with myoepithelial markers in minor salivary gland tumors revealed that p63 expression is almost comparable with VIM in detecting myoepithelial cells, an immunolabeling pattern not followed by p40, and consequently, caution has to be taken during the interpretation of salivary gland tumor exhibiting an p63/p40 phenotype in order to avoid a misdiagnosis.

  11. Study reports that DNA methylation profiles may vary even among chronic lymphocytic leukemia (CLL) patients with similar somatic hypermutation status and highlight p63 as a novel pro-survival factor in CLL.

  12. Structure determination of the transactivation domains of p63 and p73 in complex with the p300 Taz2 domain further revealed that, in contrast to p53 and p73, p63 has a single transactivation domain.

  13. a critical role for p63 in response to DNA damage in cervical cancer cells, is reported.

  14. TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.

  15. Cullin3/KCTD5 downregulates the DNA-binding affinity of DeltaNp63alpha, impairing either its transactivity or its transinhibitory activity. Functionally, Cullin3/KCTD5 abates the proproliferation activity of DeltaNp63alpha. These findings suggest that KCTD5-based CRL3 may mediate monoubiquitination and is a novel regulator of DeltaNp63alpha.

  16. Letter: loss of TP63/TRP63 directly facilitates cutaneous squamous cell carcinoma development and progression through activation of Wnt/beta-catenin signaling.

  17. P63alpha inhibited cyclin D1 protein expression.

  18. Exogenous p51A gene can increase its expression in A549 and NCI-H1299 cells, suppress cell growth and induce cell apoptosis. Moreover, it can also cooperate with chemotherapy and reduce the dose and side-effect. p51A gene can suppress tumours in spite of p53 status and p21 gene might be involved.

  19. Case Report: TP63 mutation responsible for ankyloblepharon-ectodermal defects-cleft lip/palate-syndrome with choanal atresia and skin erosions.

  20. Thus, epithelial barrier and ciliogenesis of nasal epithelium are regulated in a p63-negative manner in normal and upper airway diseases.

T-Complex Protein 1 (TCP1) profil antigène

Antigen Summary

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with T-Complex Protein 1 (TCP1) Kits ELISA

  • t-complex protein 1 (Tcp1) anticorps
  • tumor protein p63 (TP63) anticorps
  • tumor protein p63 (Tp63) anticorps
  • AI528772 anticorps
  • AIS anticorps
  • B(p51A) anticorps
  • B(p51B) anticorps
  • c-cpn anticorps
  • CCT anticorps
  • Cct1 anticorps
  • Ccta anticorps
  • EEC3 anticorps
  • Ket anticorps
  • LMS anticorps
  • NBP anticorps
  • OFC8 anticorps
  • p40 anticorps
  • p51 anticorps
  • p53CP anticorps
  • p63 anticorps
  • p73H anticorps
  • P73l anticorps
  • RHS anticorps
  • SHFM4 anticorps
  • Tcp-1 anticorps
  • TP53CP anticorps
  • TP53L anticorps
  • Tp63 anticorps
  • Tp73l anticorps
  • TRic anticorps
  • Trp63 anticorps

Protein level used designations for T-Complex Protein 1 (TCP1) Kits ELISA

CCT-alpha , T-complex protein 1 subunit alpha , T-complex protein 1 subunit alpha A , T-complex protein 1 subunit alpha B , TCP-1-A , TCP-1-B , TCP-1-alpha , t-complex polypeptide 1 , tailless complex polypeptide 1A , tailless complex polypeptide 1B , CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , transformation related protein 63 , tumor protein 63 kDa

21454 Mus musculus
8626 Homo sapiens
246334 Rattus norvegicus
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