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TAPBP encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane.
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Human Polyclonal TAPBP Primary Antibody pour IHC, IHC (p) - ABIN4357823
Sokol, Koelzer, Rau, Karamitopoulou, Zlobec, Lugli: Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer. dans Journal of translational medicine 2015
Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Tpn defined the characteristic carboxy termini of canonical MHC I peptides.
modification of Tapasin can enhance the presentation of targeting antigens via intracellular delivery to DCs and elicit specific CTL immune responses efficiently
Data show that tapasin expression is enhanced by beta 2-microglobulin (Montrer B2M Anticorps) via both transcriptional and post-transcriptional mechanisms.
Deletion of a loop within the tapasin C-terminal Ig-like domain (Delta334-342) prevented tapasin association with the MHC class I molecule K(d).
E2F1 (Montrer E2F1 Anticorps) is an essential transcription factor for tapasin.
showed that a large disulfide-bonded complex was present in the mouse cells that included ERp57 (Montrer PDIA3 Anticorps), tapasin, and K(d).
Role of tapasin in MHC class I antigen presentation in vivo.
Data show that cell surface expression of TAP-independent class I complexes is modulated by tapasin levels and is enhanced by interferon-gamma (Montrer IFNG Anticorps).
tapasin has a essential function of tapasin in quality control of HLA-G (Montrer HLAG Anticorps) molecules
A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.
The results demonstrated that the mRNA expression levels of tapasin were significantly downregulated in patients with chronic hepatitis B (CHB) compared with in healthy controls and patients with acute hepatitis B Furthermore, the apoptotic rate of CD8 (Montrer CD8A Anticorps)+ T cells was increased in patients with CHB compared with in the other two groups.
The disruption of TAP1 (Montrer TAP1 Anticorps) and TAPBP generates pluripotent embryonic stem cells with reduced immunogenicity.
Fluctuation and entropy analyses show how tapasin chaperones major histocompatibility complex class I by stabilising it in a peptide-receptive conformation.
reduction in tapasin expression is associated with tumor progression in colorectal cancer
Data suggest that tapasin (Tsn) binds to MHC I with suboptimal cargo and thereby adjusts the energy landscape in favor of MHC I complexes with immunodominant epitopes.
TAP/TPN complex formation is driven by hydrophobic interactions via leucine zipper-like motifs.
TAP2 (Montrer TAP2 Anticorps), HLA-DOA (Montrer HLA-DOA Anticorps), HLA-DOB (Montrer HLA-DOB Anticorps), and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population
Analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for glioblastoma multiforme patients, especially when considering immunotherapy.
Modified TAPBP gene function may contribute to the development of refractory chronic rhinosinusitis via reduction of circulating CD8 (Montrer CD8A Anticorps) lymphocytes.
Targeted re-sequencing identified rs3106189 at the 5' UTR (Montrer UTS2R Anticorps) of TAPBP and rs1052918 at the 3' UTR (Montrer UTS2R Anticorps) of TCF3 (Montrer TCF3 Anticorps) to be associated with the overall survival of colorectal cancer patients.
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
, TAP binding protein
, TAP-associated protein
, TAP-binding protein